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    FKBP12 FK506-binding protein 12 [ Arabidopsis thaliana (thale cress) ]

    Gene ID: 836556, updated on 18-Sep-2024

    Summary

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    Official Symbol
    FKBP12
    Official Full Name
    FK506-binding protein 12
    Primary source
    TAIR:AT5G64350
    Locus tag
    AT5G64350
    See related
    Araport:AT5G64350
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Arabidopsis thaliana (ecotype: Columbia)
    Lineage
    Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
    Also known as
    ARABIDOPSIS THALIANA FK506-BINDING PROTEIN 12; ATFKBP12; FK506-binding protein 12; FKP12; IMMUNOPHILIN; MSJ1.19; MSJ1_19
    Summary
    Encodes FK506-binding protein 12 (FKBP12 or FKP12). FKP12 overexpression dramatically enhances rapamycin sensitivity, whereas rapamycin inhibition is relieved in transgenic plants deficient in FKP12.
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    Genomic context

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    See FKBP12 in Genome Data Viewer
    Location:
    chromosome: 5
    Exon count:
    5
    Sequence:
    Chromosome: 5; NC_003076.8 (25734590..25736145, complement)

    Chromosome 5 - NC_003076.8Genomic Context describing neighboring genes Neighboring gene Pentatricopeptide repeat (PPR) superfamily protein Neighboring gene Phototropic-responsive NPH3 family protein Neighboring gene transcription factor SAC51 Neighboring gene Chaperone DnaJ-domain superfamily protein Neighboring gene beta-ureidopropionase

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003076.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. CONSTANS-FKBP12 interaction contributes to modulation of photoperiodic flowering in Arabidopsis. Serrano-Bueno G, et al. Plant J, 2020 Mar. PMID 31661582
    2. An Arabidopsis immunophilin, AtFKBP12, binds to AtFIP37 (FKBP interacting protein) in an interaction that is disrupted by FK506. Faure JD, et al. Plant J, 1998 Sep. PMID 9807817
    3. A proteomic strategy for global analysis of plant protein complexes. Aryal UK, et al. Plant Cell, 2014 Oct. PMID 25293756, Free PMC Article
    4. Evidence for network evolution in an Arabidopsis interactome map. Arabidopsis Interactome Mapping Consortium. Science, 2011 Jul 29. PMID 21798944, Free PMC Article
    5. Global Analysis of Membrane-associated Protein Oligomerization Using Protein Correlation Profiling. McBride Z, et al. Mol Cell Proteomics, 2017 Nov. PMID 28887381, Free PMC Article

    See all (6) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. CONSTANS-FKBP12 interaction contributes to modulation of photoperiodic flowering in Arabidopsis.
      Title: CONSTANS-FKBP12 interaction contributes to modulation of photoperiodic flowering in Arabidopsis.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    NM_125831.3

    Gene Ontology Provided by TAIR

    Function Evidence Code Pubs
    enables peptidyl-prolyl cis-trans isomerase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in biological_process ND
    No biological Data available
    more info
    		  
    Component Evidence Code Pubs
    located_in cytoplasm ISM
    Inferred from Sequence Model
    more info
    		  
    located_in cytosol HDA PubMed 
    located_in plastid HDA PubMed 

    General protein information

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    Preferred Names
    FK506-binding protein 12
    NP_201240.1
    • FK506-binding protein 12 (FKBP12); FUNCTIONS IN: FK506 binding, peptidyl-prolyl cis-trans isomerase activity; INVOLVED IN: protein folding; LOCATED IN: chloroplast thylakoid lumen; EXPRESSED IN: 24 plant structures; EXPRESSED DURING: 14 growth stages; CONTAINS InterPro DOMAIN/s: Peptidyl-prolyl cis-trans isomerase, FKBP-type (InterPro:IPR001179); BEST Arabidopsis thaliana protein match is: FKBP-like peptidyl-prolyl cis-trans isomerase family protein (TAIR:AT3G55520.1); Has 1807 Blast hits to 1807 proteins in 277 species: Archae - 0; Bacteria - 0; Metazoa - 736; Fungi - 347; Plants - 385; Viruses - 0; Other Eukaryotes - 339 (source: NCBI BLink).

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003076.8 Reference assembly

      Range
      25734590..25736145 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_125831.3 → NP_201240.1  FK506-binding protein 12 [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_201240.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      O04263, Q8LGG0
      UniProtKB/TrEMBL
      A0A178UAW8, A0A5S9YH60
      Conserved Domains (1) summary
      COG0545
      Location:2 → 111
      FkpA; FKBP-type peptidyl-prolyl cis-trans isomerase [Posttranslational modification, protein turnover, chaperones]
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8LGG0.2

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