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    CIPK23 CBL-interacting protein kinase 23 [ Arabidopsis thaliana (thale cress) ]

    Gene ID: 839907, updated on 18-Sep-2024

    Summary

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    Official Symbol
    CIPK23
    Official Full Name
    CBL-interacting protein kinase 23
    Primary source
    TAIR:AT1G30270
    Locus tag
    AT1G30270
    See related
    Araport:AT1G30270
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Arabidopsis thaliana (ecotype: Columbia)
    Lineage
    Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
    Also known as
    ATCIPK23; CBL-interacting protein kinase 23; F12P21.6; F12P21_6; LKS1; LOW-K+-SENSITIVE 1; PKS17; SNF1-RELATED PROTEIN KINASE 3.23; SnRK3.23; SOS2-like protein kinase 17
    Summary
    Arabidopsis thaliana CBL-interacting protein kinase 23. CIPK23 serves as a positive regulator of the potassium transporter AKT1 by directly phosphorylating AKT1. CIPK23 is activated by the binding of two calcineurin B-like proteins, CBL1 and CBL9.
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    Genomic context

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    See CIPK23 in Genome Data Viewer
    Location:
    chromosome: 1
    Exon count:
    14
    Sequence:
    Chromosome: 1; NC_003070.9 (10654800..10658924)

    Chromosome 1 - NC_003070.9Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene galactosyltransferase family protein Neighboring gene Chaperone DnaJ-domain superfamily protein Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003070.9

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. CIPK23 regulates blue light-dependent stomatal opening in Arabidopsis thaliana. Inoue SI, et al. Plant J, 2020 Nov. PMID 32780529, Free PMC Article
    2. CIPK23 is involved in iron acquisition of Arabidopsis by affecting ferric chelate reductase activity. Tian Q, et al. Plant Sci, 2016 May. PMID 26993237
    3. The Kinase CIPK23 Inhibits Ammonium Transport in Arabidopsis thaliana. Straub T, et al. Plant Cell, 2017 Feb. PMID 28188265, Free PMC Article
    4. CHL1 functions as a nitrate sensor in plants. Ho CH, et al. Cell, 2009 Sep 18. PMID 19766570
    5. Phosphorylation by CIPK23 regulates the high-affinity Mn transporter NRAMP1 in Arabidopsis. Kosuth T, et al. FEBS Lett, 2023 Aug. PMID 37501385

    See all (32) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Phosphorylation by CIPK23 regulates the high-affinity Mn transporter NRAMP1 in Arabidopsis.
      Title: Phosphorylation by CIPK23 regulates the high-affinity Mn transporter NRAMP1 in Arabidopsis.
    2. CBL1/9-CIPK23-NRAMP1 axis regulates manganese toxicity.
      Title: CBL1/9-CIPK23-NRAMP1 axis regulates manganese toxicity.
    3. The CIPK23 protein kinase represses SLAC1-type anion channels in Arabidopsis guard cells and stimulates stomatal opening.
      Title: The CIPK23 protein kinase represses SLAC1-type anion channels in Arabidopsis guard cells and stimulates stomatal opening.
    4. STOP1 Regulates LKS1 Transcription and Coordinates K(+)/NH4(+) Balance in Arabidopsis Response to Low-K(+) Stress.
      Title: STOP1 Regulates LKS1 Transcription and Coordinates K(+)/NH(4)(+) Balance in Arabidopsis Response to Low-K(+) Stress.
    5. A transcription factor STOP1-centered pathway coordinates ammonium and phosphate acquisition in Arabidopsis.
      Title: A transcription factor STOP1-centered pathway coordinates ammonium and phosphate acquisition in Arabidopsis.
    6. CIPK23 regulates blue light-dependent stomatal opening in Arabidopsis thaliana.
      Title: CIPK23 regulates blue light-dependent stomatal opening in Arabidopsis thaliana.
    7. The findings uncover additional pleiotropic roles of STOP1 mediated by CIPK23, which regulates various ion transporters including those regulating K+-homeostasis, which may induce a trade-off between drought tolerance and other traits.
      Title: Sensitive to Proton Rhizotoxicity1 Regulates Salt and Drought Tolerance of Arabidopsis thaliana through Transcriptional Regulation of CIPK23.
    8. CIPK23 occupies a key position in controlling ion balance and ion homeostasis in the plant cell.
      Title: The Kinase CIPK23 Inhibits Ammonium Transport in Arabidopsis thaliana.
    9. using mutants in known dormancy-related genes [DELAY OF GERMINATION 1 (DOG1), MOTHER OF FLOWERING TIME (MFT), CBL-INTERACTING PROTEIN KINASE 23 (CIPK23) and PHYTOCHROME A (PHYA)] components of the circadian clock are shown to be involved in coordination of the annual seed dormancy cycle.
      Title: A laboratory simulation of Arabidopsis seed dormancy cycling provides new insight into its regulation by clock genes and the dormancy-related genes DOG1, MFT, CIPK23 and PHYA.
    10. CIPK23 and AtKC1 exhibit distinct effects; however, they act synergistically and balance K(+) uptake/leakage to modulate AKT1-mediated low potassium responses in Arabidopsis.
      Title: AtKC1 and CIPK23 Synergistically Modulate AKT1-Mediated Low-Potassium Stress Responses in Arabidopsis.
    Submit: New GeneRIF Correction See all GeneRIFs (16)

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    NM_001332883.1
    NM_001332884.1
    NM_102766.6

    Gene Ontology Provided by TAIR

    Function Evidence Code Pubs
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables protein serine/threonine kinase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables protein serine/threonine kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within potassium ion import across plasma membrane IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within regulation of stomatal movement IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within response to nutrient IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within response to water deprivation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in signal transduction IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in stomatal movement IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    acts_upstream_of_or_within stomatal movement IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in chloroplast ISM
    Inferred from Sequence Model
    more info
    		  
    located_in cytoplasm HDA PubMed 
    located_in cytosol IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nucleus HDA PubMed 
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in plasma membrane IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    located_in plasma membrane ISM
    Inferred from Sequence Model
    more info
    		  
    located_in plastid HDA PubMed 

    General protein information

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    Preferred Names
    CBL-interacting protein kinase 23
    NP_564353.1
    • CBL-interacting protein kinase 23 (CIPK23); CONTAINS InterPro DOMAIN/s: Protein kinase, ATP binding site (InterPro:IPR017441), Serine/threonine-protein kinase domain (InterPro:IPR002290), NAF/FISL domain (InterPro:IPR018451), Serine/threonine-protein kinase-like domain (InterPro:IPR017442), Protein kinase-like domain (InterPro:IPR011009), Serine/threonine-protein kinase, active site (InterPro:IPR008271), NAF domain (InterPro:IPR004041), CBL-interacting protein kinase (InterPro:IPR020660), Protein kinase, catalytic domain (InterPro:IPR000719), Calcium/calmodulin-dependent protein kinase-like (InterPro:IPR020636); BEST Arabidopsis thaliana protein match is: CBL-interacting protein kinase 9 (TAIR:AT1G01140.1); Has 132391 Blast hits to 130112 proteins in 4449 species: Archae - 167; Bacteria - 15551; Metazoa - 48688; Fungi - 13416; Plants - 32041; Viruses - 531; Other Eukaryotes - 21997 (source: NCBI BLink).

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003070.9 Reference assembly

      Range
      10654800..10658924
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_102766.6 → NP_564353.1  CBL-interacting protein kinase 23 [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_564353.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q93VD3, Q9C753
      UniProtKB/TrEMBL
      A0A178W2X4, A0A5S9WG58, A0A7G2DU57
      Conserved Domains (2) summary
      cd12195
      Location:334 → 449
      CIPK_C; C-terminal regulatory domain of Calcineurin B-Like (CBL)-interacting protein kinases
      cd14663
      Location:30 → 285
      STKc_SnRK3; Catalytic domain of the Serine/Threonine Kinases, Sucrose nonfermenting 1-related protein kinase subfamily 3

    2. NM_001332883.1 → NP_001320726.1  CBL-interacting protein kinase 23 [Arabidopsis thaliana]

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A1P8ANQ5, A0A7G2DU57

    3. NM_001332884.1 → NP_001320727.1  CBL-interacting protein kinase 23 [Arabidopsis thaliana]

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A178W3M8, A0A1P8ANR3, A0A384KCC6, A0A7G2DU57
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q93VD3.1

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