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    Pglyrp3 peptidoglycan recognition protein 3 [ Mus musculus (house mouse) ]

    Gene ID: 242100, updated on 13-Jan-2025

    Summary

    Official Symbol
    Pglyrp3provided by MGI
    Official Full Name
    peptidoglycan recognition protein 3provided by MGI
    Primary source
    MGI:MGI:2685266
    See related
    Ensembl:ENSMUSG00000042244 AllianceGenome:MGI:2685266
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Gm420
    Summary
    Predicted to enable peptidoglycan binding activity; peptidoglycan immune receptor activity; and protein heterodimerization activity. Acts upstream of or within biological process involved in interaction with host; negative regulation of natural killer cell differentiation involved in immune response; and negative regulation of type II interferon production. Predicted to be located in extracellular region. Predicted to be part of protein-containing complex. Is expressed in several structures, including adrenal gland; alimentary system; immune system; nervous system; and testis. Orthologous to human PGLYRP3 (peptidoglycan recognition protein 3). [provided by Alliance of Genome Resources, Jan 2025]
    Expression
    Low expression observed in reference dataset See more
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    Genomic context

    See Pglyrp3 in Genome Data Viewer
    Location:
    3 F1; 3 40.14 cM
    Exon count:
    8
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 3 NC_000069.7 (91919784..91939979)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 3 NC_000069.6 (92012477..92032672)

    Chromosome 3 - NC_000069.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 46837 Neighboring gene STARR-seq mESC enhancer starr_08308 Neighboring gene zinc finger CCCH type containing 14 pseudogene Neighboring gene STARR-seq mESC enhancer starr_08309 Neighboring gene macrophage migration inhibitory factor, pseudogene 3 Neighboring gene loricrin cornified envelope precursor protein Neighboring gene proline rich 9

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (6) 
    • Targeted (1)  1 citation

    Pathways from PubChem

    General gene information

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables N-acetylmuramoyl-L-alanine amidase activity  
    enables peptidoglycan binding  
    enables peptidoglycan binding  
    enables peptidoglycan immune receptor activity  
    enables peptidoglycan immune receptor activity  
    enables protein heterodimerization activity  
    enables protein heterodimerization activity  
    enables zinc ion binding  
    Process Evidence Code Pubs
    involved_in antimicrobial humoral immune response mediated by antimicrobial peptide  
    involved_in antimicrobial humoral immune response mediated by antimicrobial peptide  
    acts_upstream_of_or_within biological process involved in interaction with host PubMed 
    involved_in defense response to Gram-positive bacterium  
    involved_in defense response to Gram-positive bacterium  
    involved_in defense response to bacterium  
    involved_in detection of bacterium  
    involved_in detection of bacterium  
    involved_in immune response  
    involved_in innate immune response  
    involved_in killing of cells of another organism  
    involved_in killing of cells of another organism  
    acts_upstream_of_or_within negative regulation of natural killer cell differentiation involved in immune response PubMed 
    acts_upstream_of_or_within negative regulation of type II interferon production PubMed 
    involved_in peptidoglycan catabolic process  
    Component Evidence Code Pubs
    located_in extracellular region  
    part_of protein-containing complex  
    part_of protein-containing complex  

    General protein information

    Preferred Names
    peptidoglycan recognition protein 3
    Names
    PGLYRPIalpha
    PGRP-I-alpha
    peptidoglycan recognition protein I-alpha
    peptidoglycan recognition protein intermediate alpha

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_207247.4NP_997130.2  peptidoglycan recognition protein 3 precursor

      See identical proteins and their annotated locations for NP_997130.2

      Status: VALIDATED

      Source sequence(s)
      AC163215, BB619146
      Consensus CDS
      CCDS17545.1
      UniProtKB/Swiss-Prot
      A1A547, E9QMH8, Q6R1Z2
      Related
      ENSMUSP00000035737.5, ENSMUST00000047660.5
      Conserved Domains (1) summary
      smart00701
      Location:185325
      PGRP; Animal peptidoglycan recognition proteins homologous to Bacteriophage T3 lysozyme

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000069.7 Reference GRCm39 C57BL/6J

      Range
      91919784..91939979
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006501471.2XP_006501534.1  peptidoglycan recognition protein 3 isoform X1

      Conserved Domains (1) summary
      smart00701
      Location:197337
      PGRP; Animal peptidoglycan recognition proteins homologous to Bacteriophage T3 lysozyme
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