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    Thg1l tRNA-histidine guanylyltransferase 1-like (S. cerevisiae) [ Mus musculus (house mouse) ]

    Gene ID: 66628, updated on 13-Jan-2025

    Summary

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    Official Symbol
    Thg1lprovided by MGI
    Official Full Name
    tRNA-histidine guanylyltransferase 1-like (S. cerevisiae)provided by MGI
    Primary source
    MGI:MGI:1913878
    See related
    Ensembl:ENSMUSG00000011254 AllianceGenome:MGI:1913878
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Summary
    Predicted to enable several functions, including guanyl-nucleotide exchange factor activity; magnesium ion binding activity; and purine ribonucleoside triphosphate binding activity. Predicted to be involved in several processes, including protein homotetramerization; stress-induced mitochondrial fusion; and tRNA modification. Predicted to be located in mitochondrion. Predicted to be part of transferase complex. Human ortholog(s) of this gene implicated in autosomal recessive spinocerebellar ataxia 28. Orthologous to human THG1L (tRNA-histidine guanylyltransferase 1 like). [provided by Alliance of Genome Resources, Jan 2025]
    Expression
    Ubiquitous expression in CNS E11.5 (RPKM 3.2), testis adult (RPKM 2.8) and 27 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Thg1l in Genome Data Viewer
    Location:
    11 B1.1; 11 27.47 cM
    Exon count:
    9
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 11 NC_000077.7 (45836132..45846330, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 11 NC_000077.6 (45945305..45955503, complement)

    Chromosome 11 - NC_000077.7Genomic Context describing neighboring genes Neighboring gene clathrin interactor 1 Neighboring gene STARR-seq mESC enhancer starr_29303 Neighboring gene STARR-positive B cell enhancer ABC_E5218 Neighboring gene U7 snRNP-specific Sm-like protein LSM11 Neighboring gene STARR-positive B cell enhancer ABC_E11765 Neighboring gene STARR-seq mESC enhancer starr_29307 Neighboring gene STARR-seq mESC enhancer starr_29308 Neighboring gene SRY (sex determining region Y)-box 30 Neighboring gene STARR-seq mESC enhancer starr_29309 Neighboring gene predicted gene 12165

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Mitochondrial protein interactome elucidated by chemical cross-linking mass spectrometry. Schweppe DK, et al. Proc Natl Acad Sci U S A, 2017 Feb 14. PMID 28130547, Free PMC Article
    2. BGEM: an in situ hybridization database of gene expression in the embryonic and adult mouse nervous system. Magdaleno S, et al. PLoS Biol, 2006 Apr. PMID 16602821, Free PMC Article
    3. BraInMap Elucidates the Macromolecular Connectivity Landscape of Mammalian Brain. Pourhaghighi R, et al. Cell Syst, 2020 Apr 22. PMID 32325033, Free PMC Article
    4. Genome-wide expression profiling of mid-gestation placenta and embryo using a 15,000 mouse developmental cDNA microarray. Tanaka TS, et al. Proc Natl Acad Sci U S A, 2000 Aug 1. PMID 10922068, Free PMC Article
    5. Genetic determinants of micronucleus formation in vivo. Adams DJ, et al. Nature, 2024 Mar. PMID 38355793, Free PMC Article

    See all (18) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (2) 
    • Gene trapped (1) 
    • Targeted (2) 

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC107321, 1700121M19Rik, 5730409G07Rik

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ATP binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables GTP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables GTP binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables guanyl-nucleotide exchange factor activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables guanyl-nucleotide exchange factor activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables identical protein binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables identical protein binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables magnesium ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables magnesium ion binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables nucleotidyltransferase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables tRNA guanylyltransferase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables tRNA guanylyltransferase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables tRNA guanylyltransferase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Process Evidence Code Pubs
    involved_in mitochondrial fusion ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in mitochondrial fusion ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in protein homotetramerization IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in protein homotetramerization ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in response to oxidative stress ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in response to oxidative stress ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in stress-induced mitochondrial fusion ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in stress-induced mitochondrial fusion ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in tRNA 5'-end processing IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in tRNA modification ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in tRNA processing IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in tRNA processing ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in tRNA processing ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Component Evidence Code Pubs
    located_in mitochondrion IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in mitochondrion ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of transferase complex IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of transferase complex ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    probable tRNA(His) guanylyltransferase
    Names
    interphase cyctoplasmic foci protein 45
    NP_001074438.1
    NP_001277666.1
    XP_011247481.1
    XP_030102090.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001080969.3 → NP_001074438.1  probable tRNA(His) guanylyltransferase isoform 1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
      Source sequence(s)
      AK010876, AL645948
      Consensus CDS
      CCDS36132.1
      UniProtKB/Swiss-Prot
      Q562D7, Q9CY52
      UniProtKB/TrEMBL
      Q8BT63
      Related
      ENSMUSP00000011398.7, ENSMUST00000011398.13
      Conserved Domains (1) summary
      COG4021
      Location:31 → 291
      Thg1; tRNA(His) 5'-end guanylyltransferase [Translation, ribosomal structure and biogenesis]

    2. NM_001290737.1 → NP_001277666.1  probable tRNA(His) guanylyltransferase isoform 2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR and uses an alternate start codon, compared to variant 1. This variant (2) has a shorter and distinct N-terminus, compared to isoform 2.
      Source sequence(s)
      AK016076, AL645948, BF469404
      Consensus CDS
      CCDS70167.1
      UniProtKB/TrEMBL
      Q9CQT0
      Related
      ENSMUSP00000104877.2, ENSMUST00000109254.2
      Conserved Domains (2) summary
      pfam14413
      Location:107 → 223
      Thg1C; Thg1 C terminal domain
      pfam04446
      Location:3 → 104
      Thg1; tRNAHis guanylyltransferase

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000077.7 Reference GRCm39 C57BL/6J

      Range
      45836132..45846330 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_011249179.3 → XP_011247481.1  probable tRNA(His) guanylyltransferase isoform X1

      UniProtKB/TrEMBL
      Q9CQT0
      Conserved Domains (2) summary
      pfam14413
      Location:107 → 223
      Thg1C; Thg1 C terminal domain
      pfam04446
      Location:3 → 104
      Thg1; tRNAHis guanylyltransferase

    2. XM_030246230.2 → XP_030102090.1  probable tRNA(His) guanylyltransferase isoform X1

      UniProtKB/TrEMBL
      Q9CQT0
      Conserved Domains (2) summary
      pfam14413
      Location:107 → 223
      Thg1C; Thg1 C terminal domain
      pfam04446
      Location:3 → 104
      Thg1; tRNAHis guanylyltransferase
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9CY52.1 GenPept UniProtKB/Swiss-Prot:Q9CY52

    Gene LinkOut

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