GGT5 gamma-glutamyltransferase 5 [Homo sapiens (human)] - Gene

Summary

Official Symbol: GGT5provided by HGNC
Official Full Name: gamma-glutamyltransferase 5provided by HGNC
Primary source: HGNC:HGNC:4260
See related: Ensembl:ENSG00000099998 MIM:137168; AllianceGenome:HGNC:4260
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: GGL; GGT 5; GGTLA1; GGT-REL
Summary: This gene is a member of the gamma-glutamyl transpeptidase gene family, and some reports indicate that it is capable of cleaving the gamma-glutamyl moiety of glutathione. The protein encoded by this gene is synthesized as a single, catalytically-inactive polypeptide, that is processed post-transcriptionally to form a heavy and light subunit, with the catalytic activity contained within the small subunit. The encoded enzyme is able to convert leukotriene C4 to leukotriene D4, but appears to have distinct substrate specificity compared to gamma-glutamyl transpeptidase. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Oct 2014]
Expression: Ubiquitous expression in fat (RPKM 18.6), kidney (RPKM 15.2) and 24 other tissues See more
Orthologs: mouse all
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Genomic context

Location:: 22q11.23

Exon count:: 14

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCh38.p14 (GCF_000001405.40)	22	NC_000022.11 (24219654..24245142, complement)
RS_2024_08	current	T2T-CHM13v2.0 (GCF_009914755.1)	22	NC_060946.1 (24681268..24706753, complement)
RS_2024_09	previous assembly	GRCh37.p13 (GCF_000001405.25)	22	NC_000022.10 (24615622..24641110, complement)

Chromosome 22 - NC_000022.11 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: HPA RNA-seq normal tissues
Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
BioProject: PRJEB4337
Publication: PMID 24309898
Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

GGT5: a potential immunotherapy response inhibitor in gastric cancer by modulating GSH metabolism and sustaining memory CD8+ T cell infiltration.
Title: GGT5: a potential immunotherapy response inhibitor in gastric cancer by modulating GSH metabolism and sustaining memory CD8+ T cell infiltration.
GGT5 facilitates migration and invasion through the induction of epithelial-mesenchymal transformation in gastric cancer.
Title: GGT5 facilitates migration and invasion through the induction of epithelial-mesenchymal transformation in gastric cancer.
Abcc1 and Ggt5 support lymphocyte guidance through export and catabolism of S-geranylgeranyl-l-glutathione.
Title: Abcc1 and Ggt5 support lymphocyte guidance through export and catabolism of S-geranylgeranyl-l-glutathione.
Cancer-associated fibroblasts-derived gamma-glutamyltransferase 5 promotes tumor growth and drug resistance in lung adenocarcinoma.
Title: Cancer-associated fibroblasts-derived gamma-glutamyltransferase 5 promotes tumor growth and drug resistance in lung adenocarcinoma.
Formation of LTD4 was rapid when catalyzed by gamma-glutamyl transpeptidase (GGT)1 in the A549 epithelial lung cancer cell line, but considerably slower when catalyzed by GGT5 in primary bronchial epithelial cells. When A549 cells were cultured in the presence of IL-1beta, GGT1 expression increased about 2-fold. Also exosomes from A549 cells contained GGT1 and augmented LTD4 formation.
Title: Pulmonary epithelial cancer cells and their exosomes metabolize myeloid cell-derived leukotriene C4 to leukotriene D4.
Report different pattern of expression of GGT1 and GGT5 in normal human tissues.
Title: Immunolabeling of gamma-glutamyl transferase 5 in normal human tissues reveals that expression and localization differ from gamma-glutamyl transferase 1.
There is a significant association of GGT with individual metabolic syndrome components, except HDL and inflammatory parameters (hs-CRP, ferritin).
Title: Gamma-glutamyl transpeptidase level associated with metabolic syndrome and proinflammatory parameters in the young Roma population in eastern Slovakia: a population-based study.

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Phenotypes

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Review eQTL and phenotype association data in this region using PheGenI

EBI GWAS Catalog

Description
Genome-wide association analyses in Han Chinese identify two new susceptibility loci for amyotrophic lateral sclerosis. EBI GWAS Catalog EBI GWAS CatalogPubMed
Genome-wide association study identifies three novel susceptibility loci for severe Acne vulgaris. EBI GWAS Catalog EBI GWAS CatalogPubMed

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

HIV-1 interactions

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Protein interactions

Protein	Gene	Interaction	Pubs
Tat	tat	Microarray analysis indicates HIV-1 Tat-induced upregulation of gamma-glutamyltransferase 5 (GGT5) in primary human brain microvascular endothelial cells	PubMed

Go to the HIV-1, Human Interaction Database

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

SHGC-170347 (e-PCR)
- UniSTS:183586

D22S1236 (e-PCR)
- UniSTS:50161

Gene Ontology Provided by GOA

Function	Evidence Code	Pubs
enables glutathione hydrolase activity	IBA Inferred from Biological aspect of Ancestor more info
enables glutathione hydrolase activity	IDA Inferred from Direct Assay more info	PubMed
enables leukotriene C4 gamma-glutamyl transferase activity	IEA Inferred from Electronic Annotation more info
enables leukotriene-C(4) hydrolase	IBA Inferred from Biological aspect of Ancestor more info
enables leukotriene-C(4) hydrolase	IDA Inferred from Direct Assay more info	PubMed
enables peptidyltransferase activity	IDA Inferred from Direct Assay more info	PubMed

Process	Evidence Code	Pubs
involved_in amino acid metabolic process	IDA Inferred from Direct Assay more info	PubMed
involved_in fatty acid metabolic process	IDA Inferred from Direct Assay more info	PubMed
involved_in glutathione biosynthetic process	IEA Inferred from Electronic Annotation more info
involved_in glutathione catabolic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in glutathione catabolic process	IDA Inferred from Direct Assay more info	PubMed
involved_in inflammatory response	IBA Inferred from Biological aspect of Ancestor more info
involved_in leukotriene D4 biosynthetic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in leukotriene D4 biosynthetic process	IDA Inferred from Direct Assay more info	PubMed
involved_in leukotriene D4 biosynthetic process	ISS Inferred from Sequence or Structural Similarity more info
involved_in proteolysis	IDA Inferred from Direct Assay more info	PubMed

Component	Evidence Code	Pubs
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	IDA Inferred from Direct Assay more info	PubMed
located_in plasma membrane	TAS Traceable Author Statement more info

General protein information

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Preferred Names: glutathione hydrolase 5 proenzyme

Names: gamma-glutamyl cleaving enzyme; gamma-glutamyl transpeptidase-related enzyme; gamma-glutamyl transpeptidase-related protein; gamma-glutamyltransferase-like activity 1; gamma-glutamyltranspeptidase 5; leukotriene-C4 hydrolase

NP_001093251.1

EC 2.3.2.2

EC 3.4.19.13

EC 3.4.19.14

NP_001093252.1

EC 2.3.2.2

EC 3.4.19.13

EC 3.4.19.14

NP_001289393.1

EC 2.3.2.2

EC 3.4.19.13

EC 3.4.19.14

NP_001289394.1

EC 2.3.2.2

EC 3.4.19.13

EC 3.4.19.14

NP_004112.2

EC 2.3.2.2

EC 3.4.19.13

EC 3.4.19.14

XP_005261614.1

EC 2.3.2.2

EC 3.4.19.13

EC 3.4.19.14

XP_005261615.1

EC 2.3.2.2

EC 3.4.19.13

EC 3.4.19.14

XP_011528435.1

EC 2.3.2.2

EC 3.4.19.13

EC 3.4.19.14

XP_011528436.1

EC 2.3.2.2

EC 3.4.19.13

EC 3.4.19.14

XP_011528437.1

EC 2.3.2.2

EC 3.4.19.13

EC 3.4.19.14

XP_011528438.1

EC 2.3.2.2

EC 3.4.19.13

EC 3.4.19.14

XP_011528439.1

EC 2.3.2.2

EC 3.4.19.13

EC 3.4.19.14

XP_016884257.1

EC 2.3.2.2

EC 3.4.19.13

EC 3.4.19.14

XP_016884258.1

EC 2.3.2.2

EC 3.4.19.13

EC 3.4.19.14

XP_047297284.1

EC 2.3.2.2

EC 3.4.19.13

EC 3.4.19.14

XP_047297285.1

EC 2.3.2.2

EC 3.4.19.13

EC 3.4.19.14

XP_047297286.1

EC 2.3.2.2

EC 3.4.19.13

EC 3.4.19.14

XP_047297287.1

EC 2.3.2.2

EC 3.4.19.13

EC 3.4.19.14

XP_054181502.1

EC 2.3.2.2

EC 3.4.19.13

EC 3.4.19.14

XP_054181503.1

EC 2.3.2.2

EC 3.4.19.13

EC 3.4.19.14

XP_054181504.1

EC 2.3.2.2

EC 3.4.19.13

EC 3.4.19.14

XP_054181505.1

EC 2.3.2.2

EC 3.4.19.13

EC 3.4.19.14

XP_054181506.1

EC 2.3.2.2

EC 3.4.19.13

EC 3.4.19.14

XP_054181507.1

EC 2.3.2.2

EC 3.4.19.13

EC 3.4.19.14

XP_054181508.1

EC 2.3.2.2

EC 3.4.19.13

EC 3.4.19.14

XP_054181509.1

EC 2.3.2.2

EC 3.4.19.13

EC 3.4.19.14

XP_054181510.1

EC 2.3.2.2

EC 3.4.19.13

EC 3.4.19.14

XP_054181511.1

EC 2.3.2.2

EC 3.4.19.13

EC 3.4.19.14

XP_054181512.1

EC 2.3.2.2

EC 3.4.19.13

EC 3.4.19.14

XP_054181513.1

EC 2.3.2.2

EC 3.4.19.13

EC 3.4.19.14

XP_054181514.1

EC 2.3.2.2

EC 3.4.19.13

EC 3.4.19.14

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001099781.2 → NP_001093251.1 glutathione hydrolase 5 proenzyme isoform 1

See identical proteins and their annotated locations for NP_001093251.1

Status: REVIEWED

Description

Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1).

Source sequence(s)

BC073999, BU728951, BX403504

Consensus CDS

CCDS42990.1

UniProtKB/TrEMBL

B4DND4

Related

ENSP00000381340.3, ENST00000398292.3

Conserved Domains (1) summary

pfam01019
Location:60 → 582

G_glu_transpept; Gamma-glutamyltranspeptidase
NM_001099782.2 → NP_001093252.1 glutathione hydrolase 5 proenzyme isoform 3

Status: REVIEWED

Description

Transcript Variant: This variant (3) lacks an alternate in-frame exon in the 5' coding region and uses an alternate in-frame splice site in the 3' coding region, compared to variant 1. The encoded isoform (3) is shorter than isoform 1.

Source sequence(s)

AK225661, BU728951, BX403504

Consensus CDS

CCDS42989.1

UniProtKB/TrEMBL

B4DEL3

Related

ENSP00000263112.7, ENST00000263112.11

Conserved Domains (1) summary

pfam01019
Location:60 → 549

G_glu_transpept; Gamma-glutamyltranspeptidase
NM_001302464.1 → NP_001289393.1 glutathione hydrolase 5 proenzyme isoform 4

See identical proteins and their annotated locations for NP_001289393.1

Status: REVIEWED

Description

Transcript Variant: This variant (4) has multiple differences in the coding region, one of which results in a translational frameshift, compared to variant 1. The encoded isoform (4) is shorter and has a distinct C-terminus, compared to isoform 1.

Source sequence(s)

AK225661, AL117414, BU728951, BX403504

UniProtKB/Swiss-Prot

P36269

Conserved Domains (1) summary

pfam01019
Location:60 → 506

G_glu_transpept; Gamma-glutamyltranspeptidase
NM_001302465.1 → NP_001289394.1 glutathione hydrolase 5 proenzyme isoform 5

Status: REVIEWED

Description

Transcript Variant: This variant (5) lacks two alternate exons and uses an alternate splice site in the 5' coding region, compared to variant 1. The encoded isoform (5) is shorter and contains a distinct internal segment, compared to isoform 1.

Source sequence(s)

AK293683, BC073999, BU728951, BX403504

UniProtKB/TrEMBL

B4DEL3

Conserved Domains (1) summary

cl19223
Location:123 → 505

G_glu_transpept; Gamma-glutamyltranspeptidase
NM_004121.5 → NP_004112.2 glutathione hydrolase 5 proenzyme isoform 2

See identical proteins and their annotated locations for NP_004112.2

Status: REVIEWED

Description

Transcript Variant: This variant (2) uses an alternate in-frame splice site in the 3' coding region, compared to variant 1. The encoded isoform (2) is one amino acid shorter than isoform 1.

Source sequence(s)

AP000353, AP000354

Consensus CDS

CCDS13825.1

UniProtKB/Swiss-Prot

P36269, Q53XM9, Q6GMP0, Q96FC1, Q9UFM5

UniProtKB/TrEMBL

B4DND4

Related

ENSP00000330080.4, ENST00000327365.10

Conserved Domains (1) summary

pfam01019
Location:60 → 581

G_glu_transpept; Gamma-glutamyltranspeptidase

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

NC_000022.11 Reference GRCh38.p14 Primary Assembly

Range

24219654..24245142 complement

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_017028768.3 → XP_016884257.1 glutathione hydrolase 5 proenzyme isoform X6

UniProtKB/TrEMBL

B4DND4
XM_017028769.3 → XP_016884258.1 glutathione hydrolase 5 proenzyme isoform X10

UniProtKB/TrEMBL

B4DEL3
XM_011530135.3 → XP_011528437.1 glutathione hydrolase 5 proenzyme isoform X5

Conserved Domains (1) summary

pfam01019
Location:60 → 586

G_glu_transpept; Gamma-glutamyltranspeptidase
XM_005261558.4 → XP_005261615.1 glutathione hydrolase 5 proenzyme isoform X3

UniProtKB/TrEMBL

B4DND4

Conserved Domains (1) summary

pfam01019
Location:60 → 612

G_glu_transpept; Gamma-glutamyltranspeptidase
XM_005261557.4 → XP_005261614.1 glutathione hydrolase 5 proenzyme isoform X2

UniProtKB/TrEMBL

B4DND4

Conserved Domains (1) summary

pfam01019
Location:60 → 613

G_glu_transpept; Gamma-glutamyltranspeptidase
XM_011530134.3 → XP_011528436.1 glutathione hydrolase 5 proenzyme isoform X4

UniProtKB/TrEMBL

B4DND4

Conserved Domains (1) summary

pfam01019
Location:60 → 587

G_glu_transpept; Gamma-glutamyltranspeptidase
XM_011530133.3 → XP_011528435.1 glutathione hydrolase 5 proenzyme isoform X1

UniProtKB/TrEMBL

B4DND4

Conserved Domains (1) summary

pfam01019
Location:60 → 618

G_glu_transpept; Gamma-glutamyltranspeptidase
XM_011530136.3 → XP_011528438.1 glutathione hydrolase 5 proenzyme isoform X8

Conserved Domains (1) summary

pfam01019
Location:60 → 544

G_glu_transpept; Gamma-glutamyltranspeptidase
XM_047441331.1 → XP_047297287.1 glutathione hydrolase 5 proenzyme isoform X13
XM_047441330.1 → XP_047297286.1 glutathione hydrolase 5 proenzyme isoform X12

UniProtKB/TrEMBL

B4DND4
XM_047441328.1 → XP_047297284.1 glutathione hydrolase 5 proenzyme isoform X7
XM_047441329.1 → XP_047297285.1 glutathione hydrolase 5 proenzyme isoform X9

UniProtKB/TrEMBL

B4DND4
XM_011530137.4 → XP_011528439.1 glutathione hydrolase 5 proenzyme isoform X11

UniProtKB/TrEMBL

B4DND4

Conserved Domains (1) summary

pfam01019
Location:60 → 544

G_glu_transpept; Gamma-glutamyltranspeptidase

Alternate T2T-CHM13v2.0

Genomic

NC_060946.1 Alternate T2T-CHM13v2.0

Range

24681268..24706753 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_054325532.1 → XP_054181507.1 glutathione hydrolase 5 proenzyme isoform X6

UniProtKB/TrEMBL

B4DND4
XM_054325536.1 → XP_054181511.1 glutathione hydrolase 5 proenzyme isoform X10

UniProtKB/TrEMBL

B4DEL3
XM_054325531.1 → XP_054181506.1 glutathione hydrolase 5 proenzyme isoform X5
XM_054325529.1 → XP_054181504.1 glutathione hydrolase 5 proenzyme isoform X3

UniProtKB/TrEMBL

B4DND4
XM_054325528.1 → XP_054181503.1 glutathione hydrolase 5 proenzyme isoform X2

UniProtKB/TrEMBL

B4DND4
XM_054325530.1 → XP_054181505.1 glutathione hydrolase 5 proenzyme isoform X4

UniProtKB/TrEMBL

B4DND4
XM_054325527.1 → XP_054181502.1 glutathione hydrolase 5 proenzyme isoform X1

UniProtKB/TrEMBL

B4DND4
XM_054325534.1 → XP_054181509.1 glutathione hydrolase 5 proenzyme isoform X8
XM_054325539.1 → XP_054181514.1 glutathione hydrolase 5 proenzyme isoform X13
XM_054325538.1 → XP_054181513.1 glutathione hydrolase 5 proenzyme isoform X12

UniProtKB/TrEMBL

B4DND4
XM_054325533.1 → XP_054181508.1 glutathione hydrolase 5 proenzyme isoform X7
XM_054325535.1 → XP_054181510.1 glutathione hydrolase 5 proenzyme isoform X9

UniProtKB/TrEMBL

B4DND4
XM_054325537.1 → XP_054181512.1 glutathione hydrolase 5 proenzyme isoform X11

UniProtKB/TrEMBL

B4DND4