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    HECTD3 HECT domain E3 ubiquitin protein ligase 3 [ Homo sapiens (human) ]

    Gene ID: 79654, updated on 10-Dec-2024

    Summary

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    Official Symbol
    HECTD3provided by HGNC
    Official Full Name
    HECT domain E3 ubiquitin protein ligase 3provided by HGNC
    Primary source
    HGNC:HGNC:26117
    See related
    Ensembl:ENSG00000126107 MIM:618638; AllianceGenome:HGNC:26117
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Summary
    The protein encoded by this gene transfers ubiquitin from an E2 ubiquitin-conjugating enzyme to targeted substrates, leading to the degradation of those substrates. The encoded protein has been shown to transfer ubiquitin to TRIOBP to facilitate cell cycle progression, and to STX8. [provided by RefSeq, Dec 2012]
    Expression
    Ubiquitous expression in duodenum (RPKM 25.9), small intestine (RPKM 22.6) and 25 other tissues See more
    Orthologs
    mouse all
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    Genomic context

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    See HECTD3 in Genome Data Viewer
    Location:
    1p34.1
    Exon count:
    21
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 1 NC_000001.11 (45002548..45011324, complement)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 1 NC_060925.1 (44874147..44882918, complement)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (45468220..45476996, complement)

    Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene peptidylprolyl isomerase A pseudogene 35 Neighboring gene mitochondrial ribosomal protein S17 pseudogene 1 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 824 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 825 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 958 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 959 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:45479433-45479969 Neighboring gene zinc finger SWIM-type containing 5 Neighboring gene uroporphyrinogen decarboxylase Neighboring gene oligosaccharyltransferase complex subunit pseudogene 5

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    Related articles in PubMed

    1. The role of E3 ubiquitin ligase HECTD3 in cancer and beyond. Jiang Q, et al. Cell Mol Life Sci, 2020 Apr. PMID 31637449, Free PMC Article
    2. E3 ubiquitin ligase HECTD3 is a tumor suppressor and mediates the polyubiquitination of SLC7A11 to promote ferroptosis in colon cancer. Huang F, et al. Exp Cell Res, 2023 Sep 1. PMID 37422058
    3. HECTD3 regulates the tumourigenesis of glioblastoma by polyubiquitinating PARP1 and activating EGFR signalling pathway. Zhang G, et al. Br J Cancer, 2022 Nov. PMID 36088509, Free PMC Article
    4. HECTD3 promotes gastric cancer progression by mediating the polyubiquitination of c-MYC. Zhang G, et al. Cell Death Discov, 2022 Apr 9. PMID 35397617, Free PMC Article
    5. Radiation induces IRAK1 expression to promote radioresistance by suppressing autophagic cell death via decreasing the ubiquitination of PRDX1 in glioma cells. Li J, et al. Cell Death Dis, 2023 Apr 8. PMID 37031183, Free PMC Article

    See all (56) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. E3 ubiquitin ligase HECTD3 is a tumor suppressor and mediates the polyubiquitination of SLC7A11 to promote ferroptosis in colon cancer.
      Title: E3 ubiquitin ligase HECTD3 is a tumor suppressor and mediates the polyubiquitination of SLC7A11 to promote ferroptosis in colon cancer.
    2. HECTD3 regulates the tumourigenesis of glioblastoma by polyubiquitinating PARP1 and activating EGFR signalling pathway.
      Title: HECTD3 regulates the tumourigenesis of glioblastoma by polyubiquitinating PARP1 and activating EGFR signalling pathway.
    3. This review describes the progress in the recent studies of HECTD3 in cancer and other diseases. [review]
      Title: The role of E3 ubiquitin ligase HECTD3 in cancer and beyond.
    4. HECTD3 as a tumor suppressor modulating the activity of this important oncogenic signaling pathway.
      Title: HECTD3 Mediates an HSP90-Dependent Degradation Pathway for Protein Kinase Clients.
    5. Overexpression of MALT1 partially rescues HECTD3 depletion-induced apoptosis.
      Title: The HECTD3 E3 ubiquitin ligase suppresses cisplatin-induced apoptosis via stabilizing MALT1.
    6. All these findings suggest that HECTD3 may facilitate cell cycle progression via regulating ubiquitination and degradation of Tara.
      Title: The E3 ubiquitin ligase HECTD3 regulates ubiquitination and degradation of Tara.
    Submit: New GeneRIF Correction

    Phenotypes

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    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • FLJ21156, FLJ31983, MGC161630

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables syntaxin binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ubiquitin-protein transferase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables ubiquitin-protein transferase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables ubiquitin-protein transferase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Process Evidence Code Pubs
    involved_in proteasome-mediated ubiquitin-dependent protein catabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in proteasome-mediated ubiquitin-dependent protein catabolic process IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in protein ubiquitination IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in perinuclear region of cytoplasm ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  

    General protein information

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    Preferred Names
    E3 ubiquitin-protein ligase HECTD3
    Names
    HECT domain containing E3 ubiquitin protein ligase 3
    HECT-type E3 ubiquitin transferase HECTD3
    NP_078878.3
    XP_047286443.1
    XP_054194713.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_033058.1 RefSeqGene

      Range
      5032..13808
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_024602.6 → NP_078878.3  E3 ubiquitin-protein ligase HECTD3

      See identical proteins and their annotated locations for NP_078878.3

      Status: REVIEWED

      Source sequence(s)
      AK056545, AK056873, AK096462, AL359473, DA332198
      Consensus CDS
      CCDS41318.1
      UniProtKB/Swiss-Prot
      B3KPV7, B3KRH4, Q5T447, Q5T448, Q9H783
      UniProtKB/TrEMBL
      B4DVK6
      Related
      ENSP00000361245.4, ENST00000372172.5
      Conserved Domains (2) summary
      cd08666
      Location:238 → 371
      APC10-HECTD3; APC10-like DOC1 domain of HECTD3, a HECT E3 ubiquitin ligase protein that mediates substrate ubiquitination
      pfam00632
      Location:579 → 845
      HECT; HECT-domain (ubiquitin-transferase)

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000001.11 Reference GRCh38.p14 Primary Assembly

      Range
      45002548..45011324 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_047430487.1 → XP_047286443.1  E3 ubiquitin-protein ligase HECTD3 isoform X1

      UniProtKB/TrEMBL
      A1A4G1

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060925.1 Alternate T2T-CHM13v2.0

      Range
      44874147..44882918 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054338738.1 → XP_054194713.1  E3 ubiquitin-protein ligase HECTD3 isoform X1

      UniProtKB/TrEMBL
      A1A4G1
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q5T447.1 GenPept UniProtKB/Swiss-Prot:Q5T447

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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