Kcnv1 potassium voltage-gated channel modifier subfamily V member 1 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Kcnv1provided by RGD
Official Full Name: potassium voltage-gated channel modifier subfamily V member 1provided by RGD
Primary source: RGD:621264
See related: EnsemblRapid:ENSRNOG00000004117 AllianceGenome:RGD:621264
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: Kv8.1; kv2.3r
Summary: Enables potassium channel activity. Predicted to be involved in action potential and potassium ion transmembrane transport. Predicted to be located in intercellular bridge and plasma membrane. Predicted to be part of voltage-gated potassium channel complex. Predicted to be active in membrane. Orthologous to human KCNV1 (potassium voltage-gated channel modifier subfamily V member 1). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Restricted expression toward (RPKM 149.4) See more
Orthologs: human mouse all
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Genomic context

Location:: 7q31

Exon count:: 4

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	7	NC_086025.1 (78145319..78153794, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	7	NC_051342.1 (76260695..76269170, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	7	NC_005106.4 (84016864..84023205, complement)

Chromosome 7 - NC_086025.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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General gene information

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Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables potassium channel activity	IDA Inferred from Direct Assay more info	PubMed
enables potassium channel regulator activity	IBA Inferred from Biological aspect of Ancestor more info
enables voltage-gated potassium channel activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in action potential	IBA Inferred from Biological aspect of Ancestor more info
involved_in potassium ion transmembrane transport	IBA Inferred from Biological aspect of Ancestor more info
involved_in protein homooligomerization	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in intercellular bridge	IEA Inferred from Electronic Annotation more info
located_in intercellular bridge	ISO Inferred from Sequence Orthology more info
is_active_in membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	ISO Inferred from Sequence Orthology more info
part_of voltage-gated potassium channel complex	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: potassium voltage-gated channel subfamily V member 1

Names: neuronal potassium channel alpha subunit; potassium channel, subfamily V, member 1; potassium channel, voltage-gated modifier subfamily V, member 1; voltage-gated potassium channel subunit Kv2.3r; voltage-gated potassium channel subunit Kv8.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_021697.3 → NP_067729.1 potassium voltage-gated channel subfamily V member 1

See identical proteins and their annotated locations for NP_067729.1

Status: VALIDATED

Source sequence(s)

JAXUCZ010000007

UniProtKB/Swiss-Prot

P97557

UniProtKB/TrEMBL

A6HRC5

Related

ENSRNOP00000005556.1, ENSRNOT00000005556.6

Conserved Domains (2) summary

cl38908
Location:44 → 163

BTB_POZ; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain superfamily

pfam00520
Location:212 → 438

Ion_trans; Ion transport protein