Tnfrsf11b TNF receptor superfamily member 11B [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Tnfrsf11bprovided by RGD
Official Full Name: TNF receptor superfamily member 11Bprovided by RGD
Primary source: RGD:619802
See related: EnsemblRapid:ENSRNOG00000008336 AllianceGenome:RGD:619802
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: Opg
Summary: Predicted to enable heparan sulfate binding activity. Involved in several processes, including negative regulation of bone resorption; negative regulation of odontogenesis of dentin-containing tooth; and response to estrogen. Located in extracellular space. Biomarker of congestive heart failure; myocarditis; and periapical periodontitis. Human ortholog(s) of this gene implicated in Paget's disease of bone; Paget's disease of bone 5; and osteoarthritis. Orthologous to human TNFRSF11B (TNF receptor superfamily member 11b). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in Lung (RPKM 89.4), Uterus (RPKM 58.8) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 7q32

Exon count:: 5

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	7	NC_086025.1 (87456318..87484324, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	7	NC_051342.1 (85566520..85594526, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	7	NC_005106.4 (93798580..93826586, complement)

Chromosome 7 - NC_086025.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Autophagy regulates bone loss via the RANKL/RANK/OPG axis in an experimental rat apical periodontitis model.
Title: Autophagy regulates bone loss via the RANKL/RANK/OPG axis in an experimental rat apical periodontitis model.
Mechanical force regulates root resorption in rats through RANKL and OPG.
Title: Mechanical force regulates root resorption in rats through RANKL and OPG.
The Influence of Prenatal Fumonisin Exposure on Bone Properties, as well as OPG and RANKL Expression and Immunolocalization, in Newborn Offspring Is Sex and Dose Dependent.
Title: The Influence of Prenatal Fumonisin Exposure on Bone Properties, as well as OPG and RANKL Expression and Immunolocalization, in Newborn Offspring Is Sex and Dose Dependent.
The cross-talk between matrix metalloproteinase-9, RANKL/OPG system and cardiovascular risk factors in ovariectomized rat model of postmenopausal osteoporosis.
Title: The cross-talk between matrix metalloproteinase-9, RANKL/OPG system and cardiovascular risk factors in ovariectomized rat model of postmenopausal osteoporosis.
[Effect of different orthodontic forces on the expression of T helper cell 17 cell-related cytokines in the pressure side of periodontal tissue in rats].
Title: [Effect of different orthodontic forces on the expression of T helper cell 17 cell-related cytokines in the pressure side of periodontal tissue in rats].
Osteoprotegerin Prevents Intracranial Aneurysm Progression by Promoting Collagen Biosynthesis and Vascular Smooth Muscle Cell Proliferation.
Title: Osteoprotegerin Prevents Intracranial Aneurysm Progression by Promoting Collagen Biosynthesis and Vascular Smooth Muscle Cell Proliferation.
Chondroitin Sulfate Prevents STZ Induced Diabetic Osteoporosis through Decreasing Blood Glucose, AntiOxidative Stress, Anti-Inflammation and OPG/RANKL Expression Regulation.
Title: Chondroitin Sulfate Prevents STZ Induced Diabetic Osteoporosis through Decreasing Blood Glucose, AntiOxidative Stress, Anti-Inflammation and OPG/RANKL Expression Regulation.
Effect of continuous compressive force on the expression of RANKL, OPG, and VEGF in osteocytes.
Title: Effect of continuous compressive force on the expression of RANKL, OPG, and VEGF in osteocytes.
Substance P participates in periodontitis by upregulating HIF-1alpha and RANKL/OPG ratio.
Title: Substance P participates in periodontitis by upregulating HIF-1α and RANKL/OPG ratio.
S-amlodipine inhibits inflammation and protects against endothelial dysfunction, likely via regulating the RANK/RANKL/OPG pathway, which appears to be downstream of miR-155.
Title: S-amlodipine improves endothelial dysfunction via the RANK/RANKL/OPG system by regulating microRNA-155 in hypertension.

Submit: New GeneRIF Correction See all GeneRIFs (50)

General gene information

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Markers

RH142211 (e-PCR)
- UniSTS:231461

Tnfrsf11b (e-PCR), detects polymorphism
- UniSTS:144084

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables cytokine activity	IEA Inferred from Electronic Annotation more info
enables heparan sulfate binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in apoptotic process	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within extracellular matrix organization	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of bone resorption	IDA Inferred from Direct Assay more info	PubMed
involved_in negative regulation of bone resorption	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of odontogenesis of dentin-containing tooth	IEP Inferred from Expression Pattern more info	PubMed
acts_upstream_of_or_within negative regulation of odontogenesis of dentin-containing tooth	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within negative regulation of osteoclast differentiation	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of osteoclast differentiation	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within negative regulation of tumor necrosis factor-mediated signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in response to arsenic-containing substance	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to estrogen	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to magnesium ion	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to nutrient	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to xenobiotic stimulus	IEP Inferred from Expression Pattern more info	PubMed
involved_in signal transduction	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in extracellular matrix	ISO Inferred from Sequence Orthology more info
located_in extracellular region	IEA Inferred from Electronic Annotation more info
located_in extracellular space	IDA Inferred from Direct Assay more info	PubMed
located_in extracellular space	ISO Inferred from Sequence Orthology more info
part_of receptor complex	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: tumor necrosis factor receptor superfamily member 11B

Names: Osteoprotegerin

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_012870.2 → NP_037002.1 tumor necrosis factor receptor superfamily member 11B precursor

See identical proteins and their annotated locations for NP_037002.1

Status: PROVISIONAL

Source sequence(s)

BC081830

UniProtKB/Swiss-Prot

O08727

UniProtKB/TrEMBL

A0A8I6A1T0, A6HRF7

Related

ENSRNOP00000011344.3, ENSRNOT00000011344.7

Conserved Domains (4) summary

cd00185
Location:145 → 186

TNFRSF; CRD2 [structural motif]

cd10581
Location:7 → 151

TNFRSF11B; Tumor necrosis factor receptor superfamily member 11B (TNFRSF11B), also known as Osteoprotegerin (OPG)

pfam00531
Location:288 → 365

Death; Death domain

cl22855
Location:124 → 187

TNFRSF; Tumor necrosis factor receptor superfamily (TNFRSF)