Aldh7a1 aldehyde dehydrogenase 7 family, member A1 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Aldh7a1provided by RGD
Official Full Name: aldehyde dehydrogenase 7 family, member A1provided by RGD
Primary source: RGD:1308614
See related: EnsemblRapid:ENSRNOG00000014645 AllianceGenome:RGD:1308614
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: antiquitin
Summary: Predicted to enable betaine-aldehyde dehydrogenase (NAD+) activity and identical protein binding activity. Predicted to be involved in glycine betaine biosynthetic process from choline. Predicted to be located in cytosol and mitochondrion. Human ortholog(s) of this gene implicated in early-onset vitamin B6-dependent epilepsy 4. Orthologous to human ALDH7A1 (aldehyde dehydrogenase 7 family member A1). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in Kidney (RPKM 883.4), Liver (RPKM 699.4) and 8 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 18q12.1

Exon count:: 18

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	18	NC_086036.1 (52208035..52240293, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	18	NC_051353.1 (50003242..50042193, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	18	NC_005117.4 (51619007..51651267, complement)

Chromosome 18 - NC_086036.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables L-aminoadipate-semialdehyde dehydrogenase activity	IEA Inferred from Electronic Annotation more info
enables aldehyde dehydrogenase (NAD+) activity	IEA Inferred from Electronic Annotation more info
enables aldehyde dehydrogenase (NAD+) activity	ISO Inferred from Sequence Orthology more info
enables aldehyde dehydrogenase (NAD+) activity	ISS Inferred from Sequence or Structural Similarity more info
enables betaine-aldehyde dehydrogenase (NAD+) activity	IEA Inferred from Electronic Annotation more info
enables betaine-aldehyde dehydrogenase (NAD+) activity	ISO Inferred from Sequence Orthology more info
enables betaine-aldehyde dehydrogenase (NAD+) activity	ISS Inferred from Sequence or Structural Similarity more info
enables identical protein binding	IEA Inferred from Electronic Annotation more info
enables identical protein binding	ISO Inferred from Sequence Orthology more info
enables identical protein binding	ISS Inferred from Sequence or Structural Similarity more info

Process	Evidence Code	Pubs
involved_in glycine betaine biosynthetic process from choline	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in cytosol	IEA Inferred from Electronic Annotation more info
located_in cytosol	ISO Inferred from Sequence Orthology more info
located_in cytosol	ISS Inferred from Sequence or Structural Similarity more info
located_in mitochondrion	IEA Inferred from Electronic Annotation more info
located_in mitochondrion	ISO Inferred from Sequence Orthology more info
located_in mitochondrion	ISS Inferred from Sequence or Structural Similarity more info
located_in nucleus	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: alpha-aminoadipic semialdehyde dehydrogenase

Names: P6c dehydrogenase; aldehyde dehydrogenase family 7 member A1; alpha-AASA dehydrogenase; antiquitin-1; betaine aldehyde dehydrogenase; delta1-piperideine-6-carboxylate dehydrogenase; delta1-piperideine-6-carboxylate dehydrogenease

NP_001258034.1

EC 1.2.1.3

EC 1.2.1.31

EC 1.2.1.8

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001271105.1 → NP_001258034.1 alpha-aminoadipic semialdehyde dehydrogenase

See identical proteins and their annotated locations for NP_001258034.1

Status: VALIDATED

Source sequence(s)

JAXUCZ010000018

UniProtKB/Swiss-Prot

Q64057

UniProtKB/TrEMBL

A0A8I6G8B0, A6IX60

Related

ENSRNOP00000020325.5, ENSRNOT00000020325.9

Conserved Domains (1) summary

cd07130
Location:53 → 527

ALDH_F7_AASADH; NAD+-dependent alpha-aminoadipic semialdehyde dehydrogenase, ALDH family members 7A1 and 7B