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    Fbxo38 F-box protein 38 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 307390, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Fbxo38provided by RGD
    Official Full Name
    F-box protein 38provided by RGD
    Primary source
    RGD:1311505
    See related
    EnsemblRapid:ENSRNOG00000019063 AllianceGenome:RGD:1311505
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to enable ubiquitin-like ligase-substrate adaptor activity. Predicted to be involved in several processes, including SCF-dependent proteasomal ubiquitin-dependent protein catabolic process; positive regulation of T cell mediated immune response to tumor cell; and protein K48-linked ubiquitination. Predicted to act upstream of or within positive regulation of neuron projection development. Predicted to be active in cytoplasm and nucleus. Human ortholog(s) of this gene implicated in autosomal dominant distal hereditary motor neuronopathy 6. Orthologous to human FBXO38 (F-box protein 38). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Lung (RPKM 134.5), Thymus (RPKM 129.5) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Fbxo38 in Genome Data Viewer
    Location:
    18q12.1
    Exon count:
    23
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 18 NC_086036.1 (58227253..58274320, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 18 NC_051353.1 (55956950..56004013, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 18 NC_005117.4 (57827391..57874515, complement)

    Chromosome 18 - NC_086036.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC102556293 Neighboring gene uncharacterized LOC108348797 Neighboring gene 5-hydroxytryptamine receptor 4 Neighboring gene uncharacterized LOC120098287 Neighboring gene uncharacterized LOC134483040 Neighboring gene serine protease inhibitor Kazal-type 9-like Neighboring gene serine peptidase inhibitor, Kazal type 7

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Multiple pathways regulate intracellular shuttling of MoKA, a co-activator of transcription factor KLF7. Smaldone S, et al. Nucleic Acids Res, 2006. PMID 16990251, Free PMC Article
    2. FBXO38 mediates PD-1 ubiquitination and regulates anti-tumour immunity of T cells. Meng X, et al. Nature, 2018 Dec. PMID 30487606
    3. Normalization and subtraction: two approaches to facilitate gene discovery. Bonaldo MF, et al. Genome Res, 1996 Sep. PMID 8889548
    4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables ubiquitin-like ligase-substrate adaptor activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in SCF-dependent proteasomal ubiquitin-dependent protein catabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in SCF-dependent proteasomal ubiquitin-dependent protein catabolic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of T cell activation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of T cell mediated immune response to tumor cell ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within positive regulation of neuron projection development ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in protein K48-linked ubiquitination IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in protein K48-linked ubiquitination ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    F-box only protein 38

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001372021.1 → NP_001358950.1  F-box only protein 38

      Status: VALIDATED

      Source sequence(s)
      BQ781227, JAXUCZ010000018
      UniProtKB/TrEMBL
      D3ZIK8
      Related
      ENSRNOP00000025791.6, ENSRNOT00000025790.9
      Conserved Domains (1) summary
      pfam00646
      Location:32 → 65
      F-box; F-box domain

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086036.1 Reference GRCr8

      Range
      58227253..58274320 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_063277340.1 → XP_063133410.1  F-box only protein 38 isoform X7

    2. XM_063277335.1 → XP_063133405.1  F-box only protein 38 isoform X5

    3. XM_006254822.5 → XP_006254884.1  F-box only protein 38 isoform X1

      See identical proteins and their annotated locations for XP_006254884.1

      UniProtKB/TrEMBL
      D3ZIK8
      Conserved Domains (1) summary
      pfam00646
      Location:32 → 65
      F-box; F-box domain

    4. XM_063277332.1 → XP_063133402.1  F-box only protein 38 isoform X4

    5. XM_063277337.1 → XP_063133407.1  F-box only protein 38 isoform X6

    6. XM_063277329.1 → XP_063133399.1  F-box only protein 38 isoform X2

    7. XM_063277330.1 → XP_063133400.1  F-box only protein 38 isoform X2

    8. XM_063277339.1 → XP_063133409.1  F-box only protein 38 isoform X6

    9. XM_063277334.1 → XP_063133404.1  F-box only protein 38 isoform X5

    10. XM_006254821.5 → XP_006254883.1  F-box only protein 38 isoform X1

      See identical proteins and their annotated locations for XP_006254883.1

      UniProtKB/TrEMBL
      D3ZIK8
      Conserved Domains (1) summary
      pfam00646
      Location:32 → 65
      F-box; F-box domain

    11. XM_063277341.1 → XP_063133411.1  F-box only protein 38 isoform X7

    12. XM_063277333.1 → XP_063133403.1  F-box only protein 38 isoform X4

    13. XM_063277338.1 → XP_063133408.1  F-box only protein 38 isoform X6

    14. XM_063277331.1 → XP_063133401.1  F-box only protein 38 isoform X2

    15. XM_063277336.1 → XP_063133406.1  F-box only protein 38 isoform X5

    16. XM_039096816.1 → XP_038952744.1  F-box only protein 38 isoform X4

      Conserved Domains (1) summary
      pfam00646
      Location:32 → 65
      F-box; F-box domain

    17. XM_039096815.1 → XP_038952743.1  F-box only protein 38 isoform X3

      Conserved Domains (1) summary
      pfam00646
      Location:32 → 65
      F-box; F-box domain

    18. XM_006254825.4 → XP_006254887.1  F-box only protein 38 isoform X6

      See identical proteins and their annotated locations for XP_006254887.1

      Conserved Domains (1) summary
      pfam00646
      Location:32 → 65
      F-box; F-box domain

    19. XM_006254823.4 → XP_006254885.1  F-box only protein 38 isoform X2

      See identical proteins and their annotated locations for XP_006254885.1

      UniProtKB/TrEMBL
      D3ZIK8
      Conserved Domains (1) summary
      pfam00646
      Location:32 → 65
      F-box; F-box domain

    20. XM_006254819.4 → XP_006254881.1  F-box only protein 38 isoform X1

      See identical proteins and their annotated locations for XP_006254881.1

      UniProtKB/TrEMBL
      D3ZIK8
      Conserved Domains (1) summary
      pfam00646
      Location:32 → 65
      F-box; F-box domain

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NM_001107385.1: Suppressed sequence

      Description
      NM_001107385.1: This RefSeq was suppressed temporarily based on the calculation that the encoded protein was shorter than proteins from the putative ortholog from human: FBXO38 (GeneID:81545).
    Nucleotide Protein Strain
    Heading Accession and Version

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