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    Tasor2 transcription activation suppressor family member 2 [ Mus musculus (house mouse) ]

    Gene ID: 105203, updated on 27-Nov-2024

    Summary

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    Official Symbol
    Tasor2provided by MGI
    Official Full Name
    transcription activation suppressor family member 2provided by MGI
    Primary source
    MGI:MGI:2145274
    See related
    Ensembl:ENSMUSG00000033799 AllianceGenome:MGI:2145274
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Pap20; Fam208b; mKIAA2006
    Summary
    Predicted to be involved in negative regulation of gene expression, epigenetic. Predicted to be located in cytosol. Predicted to be active in nucleoplasm. Is expressed in cerebral cortex ventricular layer and cortical plate. Orthologous to human TASOR2 (transcription activation suppressor family member 2). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Broad expression in testis adult (RPKM 6.7), CNS E11.5 (RPKM 4.2) and 24 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Tasor2 in Genome Data Viewer
    Location:
    13 A1; 13 1.99 cM
    Exon count:
    23
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 13 NC_000079.7 (3615905..3661108, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 13 NC_000079.6 (3566035..3612884, complement)

    Chromosome 13 - NC_000079.7Genomic Context describing neighboring genes Neighboring gene RIKEN cDNA 2810429I04 gene Neighboring gene STARR-seq mESC enhancer starr_33483 Neighboring gene STARR-seq mESC enhancer starr_33484 Neighboring gene STARR-positive B cell enhancer ABC_E3071 Neighboring gene predicted gene, 40654 Neighboring gene STARR-positive B cell enhancer ABC_E1159 Neighboring gene GDP dissociation inhibitor 2 Neighboring gene STARR-positive B cell enhancer ABC_E9151 Neighboring gene STARR-seq mESC enhancer starr_33488 Neighboring gene general transcription factor II A, 2 pseudogene Neighboring gene STARR-seq mESC enhancer starr_33489 Neighboring gene ankyrin repeat and SOCS box-containing 13

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Developmental regulation of membrane traffic organization during synaptogenesis in mouse diaphragm muscle. Antony C, et al. J Cell Biol, 1995 Aug. PMID 7642711, Free PMC Article
    2. Two-hybrid system screen with the small GTP-binding protein Rab6. Identification of a novel mouse GDP dissociation inhibitor isoform and two other potential partners of Rab6. Janoueix-Lerosey I, et al. J Biol Chem, 1995 Jun 16. PMID 7782346
    3. The ubiquitin ligase Uhrf2 is a master regulator of cholesterol biosynthesis and is essential for liver regeneration. Slabber CF, et al. Sci Signal, 2023 May 30. PMID 37253089
    4. Characterization of the zinc-induced Shank3 interactome of mouse synaptosome. Lee Y, et al. Biochem Biophys Res Commun, 2017 Dec 16. PMID 29111324
    5. Database resources of the National Center for Biotechnology Information. Wheeler DL, et al. Nucleic Acids Res, 2001 Jan 1. PMID 11125038, Free PMC Article

    See all (21) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (3) 

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • KIAA2006, MGC25933

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables molecular_function ND
    No biological Data available
    more info
    		  
    Process Evidence Code Pubs
    involved_in biological_process ND
    No biological Data available
    more info
    		  
    involved_in negative regulation of gene expression, epigenetic IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in cytosol IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in nucleoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    protein TASOR 2
    Names
    PBR associated protein
    family with sequence similarity 208, member B
    peripheral benzodiazepine receptor-associated protein 20
    peripherial benzodiazepine receptor associated protein
    protein FAM208B

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001360838.1 → NP_001347767.1  protein TASOR 2 isoform 2

      Status: VALIDATED

      Source sequence(s)
      AC129597
      Conserved Domains (2) summary
      pfam12480
      Location:94 → 167
      DUF3699; Protein of unknown function (DUF3699)
      pfam12509
      Location:547 → 699
      DUF3715; Protein of unknown function (DUF3715)

    2. NM_134063.3 → NP_598824.3  protein TASOR 2 isoform 1

      See identical proteins and their annotated locations for NP_598824.3

      Status: VALIDATED

      Source sequence(s)
      AK138119, AK220437, BC085160
      Consensus CDS
      CCDS49201.1
      UniProtKB/Swiss-Prot
      O35330, Q0P5P9, Q3UUS0, Q5DTT3, Q5U5L9, Q6DI89, Q6ZQM5, Q91W76
      Related
      ENSMUSP00000093774.4, ENSMUST00000096069.5
      Conserved Domains (2) summary
      pfam12480
      Location:94 → 167
      DUF3699; Protein of unknown function (DUF3699)
      pfam12509
      Location:547 → 699
      DUF3715; Protein of unknown function (DUF3715)

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000079.7 Reference GRCm39 C57BL/6J

      Range
      3615905..3661108 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006516463.3 → XP_006516526.1  protein TASOR 2 isoform X2

      Conserved Domains (1) summary
      pfam12509
      Location:325 → 477
      DUF3715; Protein of unknown function (DUF3715)

    2. XM_006516460.4 → XP_006516523.1  protein TASOR 2 isoform X1

      See identical proteins and their annotated locations for XP_006516523.1

      UniProtKB/Swiss-Prot
      O35330, Q0P5P9, Q3UUS0, Q5DTT3, Q5U5L9, Q6DI89, Q6ZQM5, Q91W76
      Conserved Domains (2) summary
      pfam12480
      Location:94 → 167
      DUF3699; Protein of unknown function (DUF3699)
      pfam12509
      Location:547 → 699
      DUF3715; Protein of unknown function (DUF3715)

    3. XM_006516461.5 → XP_006516524.1  protein TASOR 2 isoform X1

      See identical proteins and their annotated locations for XP_006516524.1

      UniProtKB/Swiss-Prot
      O35330, Q0P5P9, Q3UUS0, Q5DTT3, Q5U5L9, Q6DI89, Q6ZQM5, Q91W76
      Conserved Domains (2) summary
      pfam12480
      Location:94 → 167
      DUF3699; Protein of unknown function (DUF3699)
      pfam12509
      Location:547 → 699
      DUF3715; Protein of unknown function (DUF3715)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q5DTT3.2 GenPept UniProtKB/Swiss-Prot:Q5DTT3

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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