Fabp4 fatty acid binding protein 4 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Fabp4provided by RGD
Official Full Name: fatty acid binding protein 4provided by RGD
Primary source: RGD:69309
See related: EnsemblRapid:ENSRNOG00000010805 AllianceGenome:RGD:69309
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: aP2; Albp
Summary: Predicted to enable hormone receptor binding activity; long-chain fatty acid binding activity; and long-chain fatty acid transmembrane transporter activity. Involved in several processes, including fatty acid metabolic process; response to glucocorticoid; and response to gravity. Predicted to be located in cytoplasm. Predicted to be active in cytosol and nucleus. Biomarker of impotence and muscular atrophy. Orthologous to human FABP4 (fatty acid binding protein 4). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in Thymus (RPKM 8769.0), Adrenal (RPKM 8627.2) and 6 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 2q23

Exon count:: 3

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	2	NC_086020.1 (93488251..93492961)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	2	NC_051337.1 (91580879..91585567)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	2	NC_005101.4 (93792666..93797267)

Chromosome 2 - NC_086020.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Hyperandrogenism diminishes maternal-fetal fatty acid transport by increasing FABP4-mediated placental lipid accumulationdagger.
Title: Hyperandrogenism diminishes maternal-fetal fatty acid transport by increasing FABP4-mediated placental lipid accumulation†.
Fatty Acid-Binding Protein 4 Inhibition Promotes Locomotor and Autonomic Recovery in Rats following Spinal Cord Injury.
Title: Fatty Acid-Binding Protein 4 Inhibition Promotes Locomotor and Autonomic Recovery in Rats following Spinal Cord Injury.
High FABP4 expression is associated with myocardial ischemia reperfusion injury.
Title: FABP4 silencing ameliorates hypoxia reoxygenation injury through the attenuation of endoplasmic reticulum stress-mediated apoptosis by activating PI3K/Akt pathway.
SMCs do not express FABP4.
Title: Vasculo-protective effect of BMS-309403 is independent of its specific inhibition of fatty acid-binding protein 4.
FABP4: significant differences between DJOS and SHAM were observed in animals maintained on CD/CD.
Title: Changes of Plasma FABP4, CRP, Leptin, and Chemerin Levels in relation to Different Dietary Patterns and Duodenal-Jejunal Omega Switch Surgery in Sprague-Dawley Rats.
hypomethylation of FABP4 was regulated by DNMT1, which was a direct target of miR-152/148a, in pre-eclampsia model
Title: Modulation of FABP4 hypomethylation by DNMT1 and its inverse interaction with miR-148a/152 in the placenta of preeclamptic rats and HTR-8 cells.
Intermittent moderate exercise in the hyperphagic obese Zucker rats lasting for 10 weeks elevates adipose tissue FABP4.
Title: Aerobic training lasting for 10 weeks elevates the adipose tissue FABP4, Giα, and adiponectin expression associated by a reduced protein oxidation.
show that AP2 interacts with bile salt export pump (BSEP) at the canalicular membrane through a tyrosine motif at the carboxyl terminus of BSEP
Title: AP2 adaptor complex mediates bile salt export pump internalization and modulates its hepatocanalicular expression and transport function.
In rats fed a high-fat diet, the expressions of PPARgamma and aP2 mRNA of obesity group were much higher than those of control and obesity resistant group.
Title: [Study on PPARgamma and aP2 mRNA expression of adipose tissues in obesity and obesity resistant rats].
the release of FABP4 from adipocytes may be involved in the development of cardiac contractile dysfunction of obese subjects.
Title: Adipocyte fatty acid-binding protein suppresses cardiomyocyte contraction: a new link between obesity and heart disease.

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables fatty acid binding	IBA Inferred from Biological aspect of Ancestor more info
enables fatty acid binding	TAS Traceable Author Statement more info	PubMed
enables hormone receptor binding	ISO Inferred from Sequence Orthology more info
enables lipid binding	IEA Inferred from Electronic Annotation more info
enables long-chain fatty acid binding	ISO Inferred from Sequence Orthology more info
enables long-chain fatty acid binding	ISS Inferred from Sequence or Structural Similarity more info
enables long-chain fatty acid transmembrane transporter activity	ISO Inferred from Sequence Orthology more info
enables long-chain fatty acid transmembrane transporter activity	ISS Inferred from Sequence or Structural Similarity more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
acts_upstream_of_or_within brown fat cell differentiation	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within cellular response to lithium ion	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within cellular response to tumor necrosis factor	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within cholesterol homeostasis	ISO Inferred from Sequence Orthology more info
involved_in fatty acid metabolic process	IDA Inferred from Direct Assay more info	PubMed
involved_in fatty acid transport	IBA Inferred from Biological aspect of Ancestor more info
involved_in long-chain fatty acid transport	ISO Inferred from Sequence Orthology more info
involved_in long-chain fatty acid transport	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of_or_within negative regulation of DNA-templated transcription	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within negative regulation of protein kinase activity	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of cell population proliferation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of cold-induced thermogenesis	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of cold-induced thermogenesis	ISS Inferred from Sequence or Structural Similarity more info	PubMed
involved_in positive regulation of fat cell proliferation	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within positive regulation of inflammatory response	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within response to bacterium	ISO Inferred from Sequence Orthology more info
involved_in response to glucocorticoid	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to gravity	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to xenobiotic stimulus	IEP Inferred from Expression Pattern more info	PubMed
acts_upstream_of_or_within white fat cell differentiation	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
is_active_in cytosol	IBA Inferred from Biological aspect of Ancestor more info
located_in lipid droplet	TAS Traceable Author Statement more info
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	IEA Inferred from Electronic Annotation more info
located_in nucleus	ISO Inferred from Sequence Orthology more info
located_in nucleus	ISS Inferred from Sequence or Structural Similarity more info

General protein information

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Preferred Names: fatty acid-binding protein, adipocyte

Names: A-FABP; AFABP; adipocyte lipid-binding protein; adipocyte-type fatty acid-binding protein; fatty acid binding protein 4, adipocyte

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_053365.3 → NP_445817.2 fatty acid-binding protein, adipocyte

Status: VALIDATED

Source sequence(s)

JAXUCZ010000002

UniProtKB/Swiss-Prot

P70623

UniProtKB/TrEMBL

F7FMV4, Q5XFV4

Related

ENSRNOP00000014701.5, ENSRNOT00000014701.9

Conserved Domains (1) summary

cl10502
Location:2 → 131

lipocalin_FABP; lipocalin/cytosolic fatty acid-binding protein family