Coro1a coronin 1A [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Coro1aprovided by RGD
Official Full Name: coronin 1Aprovided by RGD
Primary source: RGD:620009
See related: EnsemblRapid:ENSRNOG00000019430 AllianceGenome:RGD:620009
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary: Predicted to enable cytoskeletal protein binding activity; phosphatidylinositol 3-kinase binding activity; and protein homodimerization activity. Predicted to be involved in several processes, including natural killer cell degranulation; negative regulation of NF-kappaB transcription factor activity; and negative regulation of canonical NF-kappaB signal transduction. Predicted to act upstream of or within several processes, including early endosome to recycling endosome transport; nerve growth factor signaling pathway; and regulation of organelle organization. Predicted to be located in several cellular components, including actin cytoskeleton; cytoplasmic vesicle; and immunological synapse. Predicted to be part of protein-containing complex. Predicted to be active in glutamatergic synapse and stereocilium tip. Human ortholog(s) of this gene implicated in coronin-1A deficiency. Orthologous to human CORO1A (coronin 1A). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in Thymus (RPKM 2295.5), Spleen (RPKM 1792.3) and 3 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 1q36

Exon count:: 12

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	1	NC_086019.1 (190726129..190731133, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	1	NC_051336.1 (181295561..181300566, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	1	NC_005100.4 (198123883..198128890, complement)

Chromosome 1 - NC_086019.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Formation of filopodia by membrane glycoprotein M6a (Gpm6a) requires actin regulator coronin-1a (Coro1a), known to regulate plasma membrane localization and activation of Rac1 and its downstream effector Pak1.
Title: Neuronal filopodium formation induced by the membrane glycoprotein M6a (Gpm6a) is facilitated by coronin-1a, Rac1, and p21-activated kinase 1 (Pak1).
Coronin 1A has an inhibitory effect on neurite outgrowth in vitro.
Title: Coronin 1A inhibits neurite outgrowth in PC12 cells.
Coronin 1A preferentially binds to PI(4,5)P(2)-containing liposomes and PI(4,5)P(2) antagonizes the ability of Coronin 1A to disassemble actin filament branches, indicating spatiotemporal regulation of Coronin 1A via direct interaction withmembrane lipid
Title: Proteome of acidic phospholipid-binding proteins: spatial and temporal regulation of Coronin 1A by phosphoinositides.

Submit: New GeneRIF Correction

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

Coro1a (e-PCR), detects polymorphism
- UniSTS:499081

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables actin binding	IEA Inferred from Electronic Annotation more info
enables actin binding	ISO Inferred from Sequence Orthology more info
enables actin filament binding	IBA Inferred from Biological aspect of Ancestor more info
enables actin filament binding	ISO Inferred from Sequence Orthology more info
enables actin monomer binding	ISO Inferred from Sequence Orthology more info
enables cytoskeletal protein binding	ISO Inferred from Sequence Orthology more info
enables identical protein binding	ISO Inferred from Sequence Orthology more info
enables myosin heavy chain binding	ISO Inferred from Sequence Orthology more info
enables phosphatidylinositol 3-kinase binding	ISO Inferred from Sequence Orthology more info
enables protein homodimerization activity	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
acts_upstream_of T cell activation	ISO Inferred from Sequence Orthology more info
involved_in T cell differentiation	NAS Non-traceable Author Statement more info	PubMed
acts_upstream_of_or_within T cell homeostasis	ISO Inferred from Sequence Orthology more info
acts_upstream_of T cell migration	ISO Inferred from Sequence Orthology more info
acts_upstream_of T cell proliferation	ISO Inferred from Sequence Orthology more info
involved_in actin cytoskeleton organization	ISO Inferred from Sequence Orthology more info
involved_in actin filament organization	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within actin filament organization	ISO Inferred from Sequence Orthology more info
involved_in biological_process	ND No biological Data available more info
acts_upstream_of_or_within calcium ion transport	ISO Inferred from Sequence Orthology more info
involved_in cell migration	IBA Inferred from Biological aspect of Ancestor more info
involved_in cell-substrate adhesion	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within cellular response to interleukin-4	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within early endosome to recycling endosome transport	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within epithelial cell migration	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within establishment of localization in cell	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within homeostasis of number of cells within a tissue	ISO Inferred from Sequence Orthology more info
NOT involved_in immunological synapse formation	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within leukocyte chemotaxis	ISO Inferred from Sequence Orthology more info
involved_in natural killer cell degranulation	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of NF-kappaB transcription factor activity	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of actin nucleation	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of canonical NF-kappaB signal transduction	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within negative regulation of neuron apoptotic process	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within negative regulation of vesicle fusion	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within nerve growth factor signaling pathway	ISO Inferred from Sequence Orthology more info
acts_upstream_of neuron apoptotic process	ISO Inferred from Sequence Orthology more info
involved_in phagocytosis	ISO Inferred from Sequence Orthology more info
involved_in phagolysosome assembly	ISO Inferred from Sequence Orthology more info
involved_in positive chemotaxis	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within positive regulation of T cell activation	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within positive regulation of T cell migration	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within positive regulation of T cell proliferation	ISO Inferred from Sequence Orthology more info
involved_in regulation of actin cytoskeleton organization	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within regulation of actin filament polymerization	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within regulation of actin polymerization or depolymerization	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within regulation of cell shape	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within regulation of release of sequestered calcium ion into cytosol	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within response to cytokine	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within thymocyte migration	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within uropod organization	ISO Inferred from Sequence Orthology more info
acts_upstream_of vesicle fusion	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in actin cytoskeleton	ISO Inferred from Sequence Orthology more info
located_in actin filament	ISO Inferred from Sequence Orthology more info
located_in axon	ISO Inferred from Sequence Orthology more info
located_in cell cortex	IEA Inferred from Electronic Annotation more info
located_in cell leading edge	ISO Inferred from Sequence Orthology more info
located_in cell-cell junction	ISO Inferred from Sequence Orthology more info
located_in cortical actin cytoskeleton	ISO Inferred from Sequence Orthology more info
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
located_in cytoskeleton	IEA Inferred from Electronic Annotation more info
located_in early endosome	ISO Inferred from Sequence Orthology more info
is_active_in glutamatergic synapse	ISO Inferred from Sequence Orthology more info
located_in immunological synapse	ISO Inferred from Sequence Orthology more info
located_in lamellipodium	ISO Inferred from Sequence Orthology more info
NOT located_in nucleus	ISO Inferred from Sequence Orthology more info
located_in phagocytic cup	ISO Inferred from Sequence Orthology more info
located_in phagocytic vesicle	ISO Inferred from Sequence Orthology more info
located_in phagocytic vesicle membrane	IEA Inferred from Electronic Annotation more info
located_in plasma membrane	ISO Inferred from Sequence Orthology more info
part_of protein-containing complex	ISO Inferred from Sequence Orthology more info
is_active_in stereocilium tip	ISO Inferred from Sequence Orthology more info
is_active_in synapse	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: coronin-1A

Names: TACO; clipin-A; coronin, actin binding protein 1A; coronin-like protein A; tryptophan aspartate-containing coat protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_130411.2 → NP_569095.1 coronin-1A

See identical proteins and their annotated locations for NP_569095.1

Status: PROVISIONAL

Source sequence(s)

AF495469

UniProtKB/Swiss-Prot

Q91ZN1

UniProtKB/TrEMBL

A0A8I6A217, A6I9B9

Conserved Domains (2) summary

sd00039
Location:37 → 79

7WD40; WD40 repeat [structural motif]

cl29593
Location:9 → 461

WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086019.1 Reference GRCr8

Range

190726129..190731133 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_017588709.3 → XP_017444198.1 coronin-1A isoform X1

UniProtKB/Swiss-Prot

Q91ZN1

UniProtKB/TrEMBL

A0A8I6A217, A6I9B9

Related

ENSRNOP00000026496.2, ENSRNOT00000026496.5

Conserved Domains (2) summary

sd00039
Location:37 → 79

7WD40; WD40 repeat [structural motif]

cl29593
Location:9 → 461

WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
XM_039083423.2 → XP_038939351.1 coronin-1A isoform X1

UniProtKB/Swiss-Prot

Q91ZN1

UniProtKB/TrEMBL

A0A8I6A217, A6I9B9

Conserved Domains (2) summary

sd00039
Location:37 → 79

7WD40; WD40 repeat [structural motif]

cl29593
Location:9 → 461

WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...