H2ax H2A.X variant histone [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: H2axprovided by RGD
Official Full Name: H2A.X variant histoneprovided by RGD
Primary source: RGD:1566119
See related: EnsemblRapid:ENSRNOG00000074924 AllianceGenome:RGD:1566119
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: H2afx; RGD1566119
Summary: Predicted to enable several functions, including chromatin-protein adaptor activity; damaged DNA binding activity; and histone binding activity. Predicted to be a structural constituent of chromatin. Involved in several processes, including cellular response to gamma radiation; cellular senescence; and cerebral cortex development. Predicted to be located in centrosome; chromosome; and nucleus. Predicted to be part of nucleosome. Predicted to be active in nucleus and site of double-strand break. Used to study hypertension; status epilepticus; and transient cerebral ischemia. Biomarker of liver benign neoplasm. Orthologous to human H2AX (H2A.X variant histone). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs: human mouse all
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Genomic context

Location:: 8q22

Exon count:: 1

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	8	NC_086026.1 (53568718..53570072)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	8	NC_051343.1 (44671907..44673262)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	8	NC_005107.4 (48665652..48666981)

Chromosome 8 - NC_086026.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Immunohistochemical Pattern of Histone H2A Variant Expression in an Experimental Model of Ischemia-Reperfusion-Induced Acute Kidney Injury.
Title: Immunohistochemical Pattern of Histone H2A Variant Expression in an Experimental Model of Ischemia-Reperfusion-Induced Acute Kidney Injury.
Suggest that gamma-H2AX may be a potential biomarker for the early detection of genotoxic bladder carcinogens.
Title: Early Detection of Genotoxic Urinary Bladder Carcinogens by Immunohistochemistry for γ-H2AX.
Exposure to Cr(VI) induced villus blunting and crypt hyperplasia in the duodenum. gamma-H2AX immunostaining was elevated in villi, but not in the crypt compartment.
Title: Synchrotron-based imaging of chromium and γ-H2AX immunostaining in the duodenum following repeated exposure to Cr(VI) in drinking water.
cytokines stimulate H2AX phosphorylation (gammaH2AX formation) in rat islets and insulinoma cells in a nitric oxide- and ATM-dependent manner.
Title: Nitric oxide induces ataxia telangiectasia mutated (ATM) protein-dependent γH2AX protein formation in pancreatic β cells.
intracellular H2AX phosphorylation (gamma-H2AX) after 4 Gy and 9 Gy whole-body in vivo irradiation was assessed in CD161 NK cells, T cell subsets and CD45RA B cells
Title: Lymphocyte subsets and their H2AX phosphorylation in response to in vivo irradiation in rats.
gamma-H2AX formation in the adult rat brain is evaluated following neuronal excitation evoked by seizure activity in vivo.
Title: Phosphorylation of histone H2A.X as an early marker of neuronal endangerment following seizures in the adult rat brain.
Experimental varicocele may induce p53-dependent apoptosis through activation of gamma-H2AX in the primary spermatocytes, and suggest that gamma-H2AX may be related to apoptotic signal transduction in experimental varicocele.
Title: Experimental varicocele induces p53-dependent germ cell apoptosis through activation of γ-H2AX.

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General gene information

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Markers

RH128239 (e-PCR)
- UniSTS:211547

RH129538 (e-PCR)
- UniSTS:212840

RH129300 (e-PCR)
- UniSTS:212607

RH131432 (e-PCR)
- UniSTS:214715

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables chromatin-protein adaptor activity	ISO Inferred from Sequence Orthology more info
enables damaged DNA binding	ISO Inferred from Sequence Orthology more info
enables enzyme binding	ISO Inferred from Sequence Orthology more info
enables histone binding	ISO Inferred from Sequence Orthology more info
enables protein heterodimerization activity	IEA Inferred from Electronic Annotation more info
enables structural constituent of chromatin	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
NOT acts_upstream_of_or_within DNA damage checkpoint signaling	ISO Inferred from Sequence Orthology more info
involved_in DNA damage checkpoint signaling	ISO Inferred from Sequence Orthology more info
involved_in DNA damage response	IBA Inferred from Biological aspect of Ancestor more info
involved_in DNA damage response	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within DNA repair	ISO Inferred from Sequence Orthology more info
involved_in cellular response to gamma radiation	IDA Inferred from Direct Assay more info	PubMed
involved_in cellular senescence	IEP Inferred from Expression Pattern more info	PubMed
involved_in cerebral cortex development	IEP Inferred from Expression Pattern more info	PubMed
acts_upstream_of_or_within double-strand break repair via homologous recombination	ISO Inferred from Sequence Orthology more info
involved_in heterochromatin formation	IBA Inferred from Biological aspect of Ancestor more info
involved_in protein localization to site of double-strand break	ISO Inferred from Sequence Orthology more info
involved_in spermatogenesis	IEP Inferred from Expression Pattern more info	PubMed
acts_upstream_of_or_within spermatogenesis	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in XY body	ISO Inferred from Sequence Orthology more info
located_in centrosome	ISO Inferred from Sequence Orthology more info
located_in chromatin	ISO Inferred from Sequence Orthology more info
located_in chromosome	ISO Inferred from Sequence Orthology more info
located_in chromosome, telomeric region	ISO Inferred from Sequence Orthology more info
located_in condensed nuclear chromosome	ISO Inferred from Sequence Orthology more info
located_in male germ cell nucleus	ISO Inferred from Sequence Orthology more info
located_in nuclear speck	IEA Inferred from Electronic Annotation more info
located_in nuclear speck	ISO Inferred from Sequence Orthology more info
located_in nucleoplasm	ISO Inferred from Sequence Orthology more info
part_of nucleosome	IBA Inferred from Biological aspect of Ancestor more info
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	ISO Inferred from Sequence Orthology more info
located_in replication fork	ISO Inferred from Sequence Orthology more info
located_in site of DNA damage	ISO Inferred from Sequence Orthology more info
is_active_in site of double-strand break	ISO Inferred from Sequence Orthology more info
located_in site of double-strand break	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: H2A.X variant histone

Names: H2A histone family, member X

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.