Orai1 ORAI calcium release-activated calcium modulator 1 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Orai1provided by RGD
Official Full Name: ORAI calcium release-activated calcium modulator 1provided by RGD
Primary source: RGD:1311873
See related: AllianceGenome:RGD:1311873
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: RGD1311873
Summary: Enables store-operated calcium channel activity. Involved in store-operated calcium entry. Located in growth cone. Human ortholog(s) of this gene implicated in immunodeficiency 9 and tubular aggregate myopathy 2. Orthologous to human ORAI1 (ORAI calcium release-activated calcium modulator 1). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in Muscle (RPKM 297.7), Kidney (RPKM 133.3) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 12q16

Exon count:: 2

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	12	NC_086030.1 (39195139..39209030, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	12	NC_051347.1 (33533151..33548361, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	12	NC_005111.4 (38981903..38995570, complement)

Chromosome 12 - NC_086030.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

The Role and Mechanism of STIM1/Orai1-Regulated Ca[2+] Influx in Myocardial Hypertrophy in Type 2 Diabetes Mellitus.
Title: The Role and Mechanism of STIM1/Orai1-Regulated Ca(2+) Influx in Myocardial Hypertrophy in Type 2 Diabetes Mellitus.
Inhibition of adenylyl cyclase 8 prevents the upregulation of Orai1 channel, which improves cardiac function after myocardial infarction.
Title: Inhibition of adenylyl cyclase 8 prevents the upregulation of Orai1 channel, which improves cardiac function after myocardial infarction.
Upregulation of Orai Channels Contributes to Aging-Related Vascular Alterations in Rat Coronary Arteries.
Title: Upregulation of Orai Channels Contributes to Aging-Related Vascular Alterations in Rat Coronary Arteries.
Inhibition of altered Orai1 channels in Muller cells protects photoreceptors in retinal degeneration.
Title: Inhibition of altered Orai1 channels in Müller cells protects photoreceptors in retinal degeneration.
Suppression of store-operated Ca(2+) entry regulated by silencing Orai1 inhibits C6 glioma cell motility via decreasing Pyk2 activity and promoting focal adhesion.
Title: Suppression of store-operated Ca(2+) entry regulated by silencing Orai1 inhibits C6 glioma cell motility via decreasing Pyk2 activity and promoting focal adhesion.
Role of Orai1 and L-type CaV1.2 channels in Endothelin-1 mediated coronary contraction under ischemia and reperfusion.
Title: Role of Orai1 and L-type Ca(V)1.2 channels in Endothelin-1 mediated coronary contraction under ischemia and reperfusion.
TRPM7 activation potentiates SOCE in enamel cells but requires ORAI.
Title: TRPM7 activation potentiates SOCE in enamel cells but requires ORAI.
Stim1 Polymorphism Disrupts Immune Signaling and Creates Renal Injury in Hypertension.
Title: Stim1 Polymorphism Disrupts Immune Signaling and Creates Renal Injury in Hypertension.
These data suggest that Orai1 SOCE is a potential therapeutic target in AKI and CKD progression.
Title: Calcium channel Orai1 promotes lymphocyte IL-17 expression and progressive kidney injury.
ORAI1 and STIM1 expression decreased in the ipsilateral temporoparietal cortex subjected to middle cerebral artery occlusion.
Title: ORAI1/STIM1 Interaction Intervenes in Stroke and in Neuroprotection Induced by Ischemic Preconditioning Through Store-Operated Calcium Entry.

Submit: New GeneRIF Correction See all GeneRIFs (63)

General gene information

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Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables calcium channel activity	ISO Inferred from Sequence Orthology more info
enables calmodulin binding	IEA Inferred from Electronic Annotation more info
enables identical protein binding	IEA Inferred from Electronic Annotation more info
enables identical protein binding	ISO Inferred from Sequence Orthology more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables store-operated calcium channel activity	IBA Inferred from Biological aspect of Ancestor more info
enables store-operated calcium channel activity	IEA Inferred from Electronic Annotation more info
enables store-operated calcium channel activity	IMP Inferred from Mutant Phenotype more info	PubMed
enables store-operated calcium channel activity	ISO Inferred from Sequence Orthology more info
enables store-operated calcium channel activity	ISS Inferred from Sequence or Structural Similarity more info

Process	Evidence Code	Pubs
involved_in adaptive immune response	IEA Inferred from Electronic Annotation more info
involved_in calcineurin-NFAT signaling cascade	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within calcium ion import	ISO Inferred from Sequence Orthology more info
involved_in calcium ion transmembrane transport	IEA Inferred from Electronic Annotation more info
involved_in calcium ion transmembrane transport	ISO Inferred from Sequence Orthology more info
involved_in ion channel modulating, G protein-coupled receptor signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in ligand-gated ion channel signaling pathway	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within mammary gland epithelium development	ISO Inferred from Sequence Orthology more info
involved_in phospholipase C-activating G protein-coupled receptor signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of adenylate cyclase activity	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of adenylate cyclase activity	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of calcium ion transport	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of calcium ion transport	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of calcium ion transport	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of insulin secretion	ISO Inferred from Sequence Orthology more info
involved_in regulation of calcium ion transport	ISO Inferred from Sequence Orthology more info
involved_in store-operated calcium entry	IBA Inferred from Biological aspect of Ancestor more info
involved_in store-operated calcium entry	IEA Inferred from Electronic Annotation more info
involved_in store-operated calcium entry	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within store-operated calcium entry	ISO Inferred from Sequence Orthology more info
involved_in store-operated calcium entry	ISO Inferred from Sequence Orthology more info
involved_in store-operated calcium entry	ISS Inferred from Sequence or Structural Similarity more info

Component	Evidence Code	Pubs
located_in basolateral plasma membrane	ISO Inferred from Sequence Orthology more info
located_in growth cone	IDA Inferred from Direct Assay more info	PubMed
is_active_in membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in membrane	ISO Inferred from Sequence Orthology more info
located_in membrane raft	ISO Inferred from Sequence Orthology more info
located_in membrane raft	ISS Inferred from Sequence or Structural Similarity more info
is_active_in plasma membrane	ISO Inferred from Sequence Orthology more info
located_in plasma membrane	ISO Inferred from Sequence Orthology more info
located_in plasma membrane	ISS Inferred from Sequence or Structural Similarity more info
located_in plasma membrane raft	IEA Inferred from Electronic Annotation more info
located_in plasma membrane raft	ISO Inferred from Sequence Orthology more info
located_in plasma membrane raft	ISS Inferred from Sequence or Structural Similarity more info

General protein information

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Preferred Names: calcium release-activated calcium channel protein 1

Names: calcium release-activated calcium modulator 1; protein orai-1; transmembrane protein 142A

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001013982.1 → NP_001014004.1 calcium release-activated calcium channel protein 1

See identical proteins and their annotated locations for NP_001014004.1

Status: PROVISIONAL

Source sequence(s)

BC088225

UniProtKB/Swiss-Prot

Q5M848

UniProtKB/TrEMBL

B2ZDP8

Conserved Domains (1) summary

pfam07856
Location:74 → 270

Orai-1; Mediator of CRAC channel activity