Gtf3c1 general transcription factor IIIC subunit 1 [Rattus norvegicus (Norway rat)] - Gene

Summary

Symbol: Gtf3c1provided by RGD
Full Name: general transcription factor IIIC subunit 1provided by RGD
Primary source: RGD:621048
See related: EnsemblRapid:ENSRNOG00000016218 AllianceGenome:RGD:621048
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: TFIIIC220; TF3C-alpha
Summary: Predicted to enable RNA polymerase III general transcription initiation factor activity. Predicted to be involved in 5S class rRNA transcription by RNA polymerase III and transcription initiation at RNA polymerase III promoter. Predicted to be located in nucleolus and nucleoplasm. Predicted to be part of ribonucleoprotein complex and transcription factor TFIIIC complex. Orthologous to human GTF3C1 (general transcription factor IIIC subunit 1). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in Adrenal (RPKM 221.2), Lung (RPKM 221.1) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 1q36

Exon count:: 37

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	1	NC_086019.1 (189634645..189700848, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	1	NC_051336.1 (180203995..180270201, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	1	NC_005100.4 (197032473..197098676, complement)

Chromosome 1 - NC_086019.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

RH128441 (e-PCR)
- UniSTS:211749

Gtf3c1 (e-PCR), detects polymorphism
- UniSTS:143275

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables DNA binding	IEA Inferred from Electronic Annotation more info
enables RNA polymerase III general transcription initiation factor activity	IEA Inferred from Electronic Annotation more info
enables RNA polymerase III general transcription initiation factor activity	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in 5S class rRNA transcription by RNA polymerase III	IBA Inferred from Biological aspect of Ancestor more info
involved_in biological_process	ND No biological Data available more info
involved_in transcription initiation at RNA polymerase III promoter	IBA Inferred from Biological aspect of Ancestor more info
involved_in transcription initiation at RNA polymerase III promoter	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in nucleolus	IEA Inferred from Electronic Annotation more info
located_in nucleolus	ISO Inferred from Sequence Orthology more info
located_in nucleoplasm	IEA Inferred from Electronic Annotation more info
located_in nucleoplasm	ISO Inferred from Sequence Orthology more info
located_in nucleus	IEA Inferred from Electronic Annotation more info
part_of ribonucleoprotein complex	IEA Inferred from Electronic Annotation more info
part_of ribonucleoprotein complex	ISO Inferred from Sequence Orthology more info
part_of transcription factor TFIIIC complex	IBA Inferred from Biological aspect of Ancestor more info
part_of transcription factor TFIIIC complex	IEA Inferred from Electronic Annotation more info
part_of transcription factor TFIIIC complex	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: general transcription factor 3C polypeptide 1

Names: TFIIIC 220 kDa subunit; TFIIIC box B-binding subunit; general transcription factor III C 1; general transcription factor IIIC, polypeptide 1, alpha; transcription factor IIIC 220 kDa subunit; transcription factor IIIC subunit alpha

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_133541.2 → NP_598225.2 general transcription factor 3C polypeptide 1

Status: VALIDATED

Source sequence(s)

JAXUCZ010000001

UniProtKB/Swiss-Prot

Q63505

UniProtKB/TrEMBL

A6I922, F1LNV7

Related

ENSRNOP00000022271.6, ENSRNOT00000022271.8

Conserved Domains (1) summary

pfam04182
Location:174 → 250

B-block_TFIIIC; B-block binding subunit of TFIIIC