Eif4e eukaryotic translation initiation factor 4E [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Eif4eprovided by MGI
Official Full Name: eukaryotic translation initiation factor 4Eprovided by MGI
Primary source: MGI:MGI:95305
See related: Ensembl:ENSMUSG00000028156 AllianceGenome:MGI:95305
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: If4e; eIF-4E; EG668879; Eif4e-ps
Summary: This gene encodes a component of the eukaryotic translation initiation factor 4F complex, which recognizes the 7-methylguanosine cap structure at the 5' end of messenger RNAs. The encoded protein aids in translation initiation by recruiting ribosomes to the 5'-cap structure. Association of this protein with the 4F complex is the rate-limiting step in translation initiation. This gene acts as a proto-oncogene, and its expression and activation is associated with transformation and tumorigenesis. It has also been associated with autism spectrum disorders. Consistently, knockout of this gene results in increased translation of neuroligins, postsynaptic proteins linked to autism spectrum disorders. Pseudogenes of this gene are found on other chromosomes. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Sep 2015]
Expression: Ubiquitous expression in CNS E18 (RPKM 11.1), CNS E11.5 (RPKM 11.0) and 25 other tissues See more
Orthologs: human all
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Genomic context

Location:: 3 G3; 3 64.3 cM

Exon count:: 11

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	3	NC_000069.7 (138231952..138265457)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	3	NC_000069.6 (138526191..138559696)

Chromosome 3 - NC_000069.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

PATL2 regulates mRNA homeostasis in oocytes by interacting with EIF4E and CPEB1.
Title: PATL2 regulates mRNA homeostasis in oocytes by interacting with EIF4E and CPEB1.
miR-34b-3p Inhibition of eIF4E Causes Post-stroke Depression in Adult Mice.
Title: miR-34b-3p Inhibition of eIF4E Causes Post-stroke Depression in Adult Mice.
Phosphorylation of eIF4E in the stroma drives the production and spatial organisation of collagen type I in the mammary gland.
Title: Phosphorylation of eIF4E in the stroma drives the production and spatial organisation of collagen type I in the mammary gland.
Supraphysiological activation of TAK1 promotes skeletal muscle growth and mitigates neurogenic atrophy.
Title: Supraphysiological activation of TAK1 promotes skeletal muscle growth and mitigates neurogenic atrophy.
mRNA translation is a therapeutic vulnerability necessary for bladder epithelial transformation.
Title: mRNA translation is a therapeutic vulnerability necessary for bladder epithelial transformation.
Pumilio2 Promotes Growth of Mature Neurons.
Title: Pumilio2 Promotes Growth of Mature Neurons.
Inhibiting the MNK1/2-eIF4E axis impairs melanoma phenotype switching and potentiates antitumor immune responses.
Title: Inhibiting the MNK1/2-eIF4E axis impairs melanoma phenotype switching and potentiates antitumor immune responses.
The distribution of eukaryotic initiation factor 4E after bouts of resistance exercise is altered by shortening of recovery periods.
Title: The distribution of eukaryotic initiation factor 4E after bouts of resistance exercise is altered by shortening of recovery periods.
Regulation of the mammalian maternal-to-embryonic transition by eukaryotic translation initiation factor 4E.
Title: Regulation of the mammalian maternal-to-embryonic transition by eukaryotic translation initiation factor 4E.
eIF4E phosphorylation modulates pain and neuroinflammation in the aged.
Title: eIF4E phosphorylation modulates pain and neuroinflammation in the aged.

Submit: New GeneRIF Correction See all GeneRIFs (70)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (2)
Gene trapped (1)
Targeted (4) 1 citation
Transposon induced (1) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

Eif4e (e-PCR), detects polymorphism
- UniSTS:142981

PMC56953P1 (e-PCR)
- UniSTS:273361

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables DNA-binding transcription factor binding	ISO Inferred from Sequence Orthology more info
enables DNA-binding transcription factor binding	ISS Inferred from Sequence or Structural Similarity more info
enables RNA 7-methylguanosine cap binding	IBA Inferred from Biological aspect of Ancestor more info
enables RNA 7-methylguanosine cap binding	ISO Inferred from Sequence Orthology more info
enables RNA 7-methylguanosine cap binding	ISS Inferred from Sequence or Structural Similarity more info
enables enzyme binding	ISO Inferred from Sequence Orthology more info
enables enzyme binding	ISS Inferred from Sequence or Structural Similarity more info
enables eukaryotic initiation factor 4G binding	ISO Inferred from Sequence Orthology more info
enables eukaryotic initiation factor 4G binding	ISS Inferred from Sequence or Structural Similarity more info
enables mRNA cap binding	IDA Inferred from Direct Assay more info	PubMed
enables mRNA cap binding	ISO Inferred from Sequence Orthology more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables translation initiation factor activity	IBA Inferred from Biological aspect of Ancestor more info
enables translation initiation factor activity	IDA Inferred from Direct Assay more info	PubMed
enables translation initiation factor activity	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in G1/S transition of mitotic cell cycle	IEA Inferred from Electronic Annotation more info
involved_in G1/S transition of mitotic cell cycle	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within behavioral fear response	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within cellular response to dexamethasone stimulus	IDA Inferred from Direct Assay more info	PubMed
involved_in mRNA export from nucleus	IDA Inferred from Direct Assay more info	PubMed
involved_in mRNA export from nucleus	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within negative regulation of neuron differentiation	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within negative regulation of translation	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of neuron differentiation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in nuclear export	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of mitotic cell cycle	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of mitotic cell cycle	ISO Inferred from Sequence Orthology more info
involved_in regulation of translation	ISO Inferred from Sequence Orthology more info
involved_in regulation of translation	ISS Inferred from Sequence or Structural Similarity more info
involved_in regulation of translation at postsynapse, modulating synaptic transmission	IDA Inferred from Direct Assay more info	PubMed
involved_in regulation of translation at postsynapse, modulating synaptic transmission	IEP Inferred from Expression Pattern more info	PubMed
involved_in regulation of translation at postsynapse, modulating synaptic transmission	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within stem cell population maintenance	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within stem cell population maintenance	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of translation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in translational initiation	IBA Inferred from Biological aspect of Ancestor more info
involved_in translational initiation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in translational initiation	NAS Non-traceable Author Statement more info	PubMed

Component	Evidence Code	Pubs
located_in P-body	ISO Inferred from Sequence Orthology more info
located_in P-body	ISS Inferred from Sequence or Structural Similarity more info
part_of RISC complex	ISO Inferred from Sequence Orthology more info
located_in chromatoid body	IDA Inferred from Direct Assay more info	PubMed
located_in cytoplasm	IDA Inferred from Direct Assay more info	PubMed
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
located_in cytoplasmic ribonucleoprotein granule	ISO Inferred from Sequence Orthology more info
located_in cytoplasmic stress granule	ISO Inferred from Sequence Orthology more info
located_in cytoplasmic stress granule	ISS Inferred from Sequence or Structural Similarity more info
located_in cytosol	ISO Inferred from Sequence Orthology more info
located_in cytosol	ISS Inferred from Sequence or Structural Similarity more info
located_in cytosol	TAS Traceable Author Statement more info
part_of eukaryotic translation initiation factor 4F complex	IBA Inferred from Biological aspect of Ancestor more info
part_of eukaryotic translation initiation factor 4F complex	ISO Inferred from Sequence Orthology more info
part_of eukaryotic translation initiation factor 4F complex	ISS Inferred from Sequence or Structural Similarity more info
part_of eukaryotic translation initiation factor 4F complex	NAS Non-traceable Author Statement more info	PubMed
is_active_in glutamatergic synapse	IDA Inferred from Direct Assay more info	PubMed
is_active_in glutamatergic synapse	IEP Inferred from Expression Pattern more info	PubMed
is_active_in glutamatergic synapse	IMP Inferred from Mutant Phenotype more info	PubMed
is_active_in glutamatergic synapse	ISO Inferred from Sequence Orthology more info
located_in nuclear body	IDA Inferred from Direct Assay more info	PubMed
located_in nuclear speck	ISO Inferred from Sequence Orthology more info
located_in nuclear speck	ISS Inferred from Sequence or Structural Similarity more info
located_in nucleus	ISO Inferred from Sequence Orthology more info
located_in nucleus	ISS Inferred from Sequence or Structural Similarity more info
located_in perinuclear region of cytoplasm	ISO Inferred from Sequence Orthology more info
located_in perinuclear region of cytoplasm	ISS Inferred from Sequence or Structural Similarity more info
is_active_in postsynapse	IDA Inferred from Direct Assay more info	PubMed
is_active_in postsynapse	IEP Inferred from Expression Pattern more info	PubMed
is_active_in postsynapse	ISO Inferred from Sequence Orthology more info
is_active_in postsynaptic cytosol	ISO Inferred from Sequence Orthology more info
part_of protein-containing complex	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: eukaryotic translation initiation factor 4E

Names: eIF-4F 25 kDa subunit; mRNA cap-binding protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001313980.1 → NP_001300909.1 eukaryotic translation initiation factor 4E isoform 2

Status: REVIEWED

Description

Transcript Variant: This variant (2) differs in the 5' UTR and contains an alternate exon in the 5' coding region that results in use of a downstream start codon compared to variant 1. It encodes isoform 2, which has a shorter N-terminus than isoform 1.

Source sequence(s)

AC113988, AK167097, BP770650

Consensus CDS

CCDS84679.1

UniProtKB/TrEMBL

A0A0G2JFB4

Related

ENSMUSP00000143104.2, ENSMUST00000196990.5

Conserved Domains (1) summary

pfam01652
Location:2 → 112

IF4E; Eukaryotic initiation factor 4E
NM_007917.4 → NP_031943.3 eukaryotic translation initiation factor 4E isoform 1

See identical proteins and their annotated locations for NP_031943.3

Status: REVIEWED

Description

Transcript Variant: This variant (1) encodes the longer isoform (1).

Source sequence(s)

AC113988, AK082867, AK167097, BP770650, CN714483

Consensus CDS

CCDS38654.1

UniProtKB/Swiss-Prot

P20415, P63073

UniProtKB/TrEMBL

Q3TK95, Q8C470

Related

ENSMUSP00000029803.8, ENSMUST00000029803.12

Conserved Domains (1) summary

pfam01652
Location:38 → 197

IF4E; Eukaryotic initiation factor 4E

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000069.7 Reference GRCm39 C57BL/6J

Range

138231952..138265457

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_006500993.4 → XP_006501056.1 eukaryotic translation initiation factor 4E isoform X1

UniProtKB/TrEMBL

Q8C470

Conserved Domains (1) summary

pfam01652
Location:51 → 210

IF4E; Eukaryotic initiation factor 4E
XM_036162887.1 → XP_036018780.1 eukaryotic translation initiation factor 4E isoform X2

UniProtKB/Swiss-Prot

P20415, P63073

UniProtKB/TrEMBL

Q3TK95, Q8C470

Related

ENSMUSP00000143690.2, ENSMUST00000200020.5

Conserved Domains (1) summary

pfam01652
Location:38 → 197

IF4E; Eukaryotic initiation factor 4E
XM_017319453.3 → XP_017174942.1 eukaryotic translation initiation factor 4E isoform X3

UniProtKB/TrEMBL

A0A0G2JFB4

Conserved Domains (1) summary

pfam01652
Location:2 → 112

IF4E; Eukaryotic initiation factor 4E