Fut4 fucosyltransferase 4 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Fut4provided by MGI
Official Full Name: fucosyltransferase 4provided by MGI
Primary source: MGI:MGI:95594
See related: Ensembl:ENSMUSG00000049307 AllianceGenome:MGI:95594
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: FAL; LeX; CD15; Ssea1; SSEA-1; FucT-IV
Summary: Enables alpha-(1->3)-fucosyltransferase activity. Involved in lymphocyte migration into lymph node; positive regulation of leukocyte tethering or rolling; and positive regulation of neutrophil migration. Located in cell periphery and cell surface. Is expressed in several structures, including ear; embryo ectoderm; extraembryonic component; genitourinary system; and spinal cord. Orthologous to human FUT4 (fucosyltransferase 4). [provided by Alliance of Genome Resources, Nov 2024]
Orthologs: human all
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Genomic context

Location:: 9 A2; 9 4.3 cM

Exon count:: 1

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	9	NC_000075.7 (14659755..14663418, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	9	NC_000075.6 (14748459..14752122, complement)

Chromosome 9 - NC_000075.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Expression of SSEA-4 and Oct-4 from somatic cells in primary mouse gastric cell culture induced by brief strong acid.
Title: Expression of SSEA-4 and Oct-4 from somatic cells in primary mouse gastric cell culture induced by brief strong acid.
Induction of the Fut4 gene in MC38 cells using CRISPR-dCas9-VPR resulted in specific neo-expression of functional Lewisx antigen on the cell surface.
Title: Transcriptional activation of fucosyltransferase (FUT) genes using the CRISPR-dCas9-VPR technology reveals potent N-glycome alterations in colorectal cancer cells.
This study suggests that baicalin facilitates endometrial reproduction via elevating FUT4 expression through Wnt/beta-catenin signaling pathway
Title: Baicalin promotes embryo adhesion and implantation by upregulating fucosyltransferase IV (FUT4) via Wnt/beta-catenin signaling pathway.
We found that Fut1 mRNA and Fut4 mRNA were upregulated, while Fut2 mRNA and Fut9 mRNA were downregulated by androgen in the caput epididymis.
Title: Different effects of androgen on the expression of Fut1, Fut2, Fut4 and Fut9 in male mouse reproductive tract.
Demonstration for the first time that CD15 is expressed in non-neural stem-like cancer cells.
Title: Evaluating stem and cancerous biomarkers in CD15+CD44+ KYSE30 cells.
alpha(1,3)-Fucosyltransferases FUT4 and FUT7 control murine susceptibility to thrombosis
Title: α(1,3)-Fucosyltransferases FUT4 and FUT7 control murine susceptibility to thrombosis.
Functional PSGL-1 generated by basophil FT-IV/VII and its subsequent binding to L-selectin could be one of the essential steps required for initial basophil recruitment and the development of IgE-chronic allergic inflammation in mice.
Title: α(1,3) Fucosyltransferases IV and VII are essential for the initial recruitment of basophils in chronic allergic inflammation.
LRP1 is necessary for the differentiation of neural stem cells toward oligodendrocytes. However, this function is independent of LeX glycosylation.
Title: A LewisX glycoprotein screen identifies the low density lipoprotein receptor-related protein 1 (LRP1) as a modulator of oligodendrogenesis in mice.
Findings suggest that Lewis X carbohydrates, which have so far been characterized as undifferentiation markers, actually operate as activators of the Notch signaling pathway for the maintenance of NSC stemness during brain development.
Title: Lewis X-carrying N-glycans regulate the proliferation of mouse embryonic neural stem cells via the Notch signaling pathway.
MiR-34a targeting of Notch ligand delta-like 1 impairs CD15+/CD133+ tumor-propagating cells and supports neural differentiation in medulloblastoma
Title: MiR-34a targeting of Notch ligand delta-like 1 impairs CD15+/CD133+ tumor-propagating cells and supports neural differentiation in medulloblastoma.

Submit: New GeneRIF Correction See all GeneRIFs (26)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (5)
Targeted (1) 1 citation

General gene information

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Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables 4-galactosyl-N-acetylglucosaminide 3-alpha-L-fucosyltransferase activity	ISO Inferred from Sequence Orthology more info
enables 4-galactosyl-N-acetylglucosaminide 3-alpha-L-fucosyltransferase activity	ISS Inferred from Sequence or Structural Similarity more info
enables alpha-(1->3)-fucosyltransferase activity	IBA Inferred from Biological aspect of Ancestor more info
enables alpha-(1->3)-fucosyltransferase activity	IDA Inferred from Direct Assay more info	PubMed
enables alpha-(1->3)-fucosyltransferase activity	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in Lewis x epitope biosynthetic process	ISO Inferred from Sequence Orthology more info
involved_in Lewis x epitope biosynthetic process	ISS Inferred from Sequence or Structural Similarity more info
involved_in fucosylation	IBA Inferred from Biological aspect of Ancestor more info
involved_in glycosphingolipid biosynthetic process	ISO Inferred from Sequence Orthology more info
involved_in glycosphingolipid biosynthetic process	ISS Inferred from Sequence or Structural Similarity more info
involved_in inflammatory response	IEA Inferred from Electronic Annotation more info
involved_in lymphocyte migration into lymph node	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in oligosaccharide metabolic process	ISO Inferred from Sequence Orthology more info
involved_in oligosaccharide metabolic process	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of leukocyte tethering or rolling	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of neutrophil migration	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in protein N-linked glycosylation	ISO Inferred from Sequence Orthology more info
involved_in protein N-linked glycosylation	ISS Inferred from Sequence or Structural Similarity more info
involved_in protein O-linked glycosylation	ISO Inferred from Sequence Orthology more info
involved_in protein O-linked glycosylation	ISS Inferred from Sequence or Structural Similarity more info
involved_in regulation of leukocyte cell-cell adhesion	ISO Inferred from Sequence Orthology more info
involved_in regulation of leukocyte cell-cell adhesion	ISS Inferred from Sequence or Structural Similarity more info

Component	Evidence Code	Pubs
located_in Golgi cisterna membrane	IEA Inferred from Electronic Annotation more info
located_in cell periphery	IDA Inferred from Direct Assay more info	PubMed
located_in cell surface	IDA Inferred from Direct Assay more info	PubMed
located_in trans-Golgi network	ISO Inferred from Sequence Orthology more info
located_in trans-Golgi network	ISS Inferred from Sequence or Structural Similarity more info

General protein information

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Preferred Names: alpha-(1,3)-fucosyltransferase 4

Names: 3-fucosyl-N-acetyl-lactosamine epitope; 4-galactosyl-N-acetylglucosaminide 3-alpha-L-fucosyltransferase; Lewis x; alpha (1,3) fucosyltransferase, myeloid specific; alpha 1,3-fucosyltransferase; fuc-TIV; fucosyltransferase IV; galactoside 3-L-fucosyltransferase; stage-specific embryonic antigen 1

NP_034372.1

EC 2.4.1.152

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_010242.3 → NP_034372.1 alpha-(1,3)-fucosyltransferase 4

See identical proteins and their annotated locations for NP_034372.1

Status: PROVISIONAL

Source sequence(s)

AK041752

Consensus CDS

CCDS22825.1

UniProtKB/Swiss-Prot

Q11127

UniProtKB/TrEMBL

B2RPT3, Q544B8

Related

ENSMUSP00000053027.6, ENSMUST00000061498.7

Conserved Domains (2) summary

pfam00852
Location:256 → 428

Glyco_transf_10; Glycosyltransferase family 10 (fucosyltransferase) C-term

pfam17039
Location:87 → 234

Glyco_tran_10_N; Fucosyltransferase, N-terminal