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    Strn4 striatin 4 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 308392, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Strn4provided by RGD
    Official Full Name
    striatin 4provided by RGD
    Primary source
    RGD:1307030
    See related
    EnsemblRapid:ENSRNOG00000016145 AllianceGenome:RGD:1307030
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Enables protein domain specific binding activity. Involved in regulation of modification of postsynaptic structure. Located in dendritic spine. Part of protein-containing complex. Is active in GABA-ergic synapse; glutamatergic synapse; and postsynapse. Orthologous to human STRN4 (striatin 4). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Brain (RPKM 195.0), Heart (RPKM 132.2) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Strn4 in Genome Data Viewer
    Location:
    1q21
    Exon count:
    18
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 1 NC_086019.1 (86614193..86639959)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 1 NC_051336.1 (77482267..77511862)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 1 NC_005100.4 (78739930..78765696)

    Chromosome 1 - NC_086019.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC120099772 Neighboring gene solute carrier family 1 member 5 Neighboring gene fukutin related protein Neighboring gene transfer RNA proline (anticodon CGG) Neighboring gene protein kinase D2 Neighboring gene dishevelled-binding antagonist of beta-catenin 3

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Determination of dendritic spine morphology by the striatin scaffold protein STRN4 through interaction with the phosphatase PP2A. Lin L, et al. J Biol Chem, 2017 Jun 9. PMID 28442576, Free PMC Article
    2. Distribution of zinedin in the rat brain. Benoist M, et al. J Neurochem, 2008 Jul. PMID 18466332
    3. Targeting of proteins of the striatin family to dendritic spines: role of the coiled-coil domain. Gaillard S, et al. Traffic, 2006 Jan. PMID 16445688
    4. Molecular cloning and characterization of phocein, a protein found from the Golgi complex to dendritic spines. Baillat G, et al. Mol Biol Cell, 2001 Mar. PMID 11251078, Free PMC Article
    5. Striatin, a calmodulin-dependent scaffolding protein, directly binds caveolin-1. Gaillard S, et al. FEBS Lett, 2001 Nov 9. PMID 11707266

    See all (10) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. STRN4 is preferentially expressed in mushroom spines, and STRN4 specifically maintains mushroom spines but not thin spines and filopodia through interaction with the phosphatase PP2A
      Title: Determination of dendritic spine morphology by the striatin scaffold protein STRN4 through interaction with the phosphatase PP2A.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables armadillo repeat domain binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables calmodulin binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables protein domain specific binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables protein phosphatase 2A binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables protein phosphatase 2A binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables protein-containing complex binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables protein-containing complex binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables protein-containing complex binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables protein-macromolecule adaptor activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in biological_process ND
    No biological Data available
    more info
    		  
    involved_in negative regulation of hippo signaling ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of modification of postsynaptic structure IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in regulation of modification of postsynaptic structure IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulation of signal transduction IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    part_of FAR/SIN/STRIPAK complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of FAR/SIN/STRIPAK complex ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in GABA-ergic synapse IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in dendrite IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in dendritic spine IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in glutamatergic synapse IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in glutamatergic synapse IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    is_active_in postsynapse IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of protein-containing complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    striatin-4
    Names
    striatin, calmodulin binding protein 4
    zinedin

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001107480.2 → NP_001100950.2  striatin-4 isoform 1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
      Source sequence(s)
      BQ198897, JAXUCZ010000001
      UniProtKB/TrEMBL
      A0A8I6AK86, F1M6V8
      Related
      ENSRNOP00000095692.2, ENSRNOT00000103486.2
      Conserved Domains (4) summary
      COG2319
      Location:422 → 752
      WD40; WD40 repeat [General function prediction only]
      cd00200
      Location:436 → 758
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
      pfam08232
      Location:63 → 188
      Striatin; Striatin family
      sd00039
      Location:449 → 495
      7WD40; WD40 repeat [structural motif]

    2. NM_001161809.1 → NP_001155281.1  striatin-4 isoform 2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) uses an alternate splice site in the central coding region, compared to variant 1. The resulting isoform (2) lacks an internal 7-aa segment, compared to isoform 1.
      Source sequence(s)
      BC168948, BF408712, BQ198897, JAXUCZ010000001
      UniProtKB/TrEMBL
      A0A8I6AK86
      Related
      ENSRNOP00000070127.1, ENSRNOT00000089715.3
      Conserved Domains (4) summary
      COG2319
      Location:415 → 745
      WD40; WD40 repeat [General function prediction only]
      cd00200
      Location:429 → 751
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
      pfam08232
      Location:63 → 188
      Striatin; Striatin family
      sd00039
      Location:442 → 488
      7WD40; WD40 repeat [structural motif]

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086019.1 Reference GRCr8

      Range
      86614193..86639959
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039111193.2 → XP_038967121.1  striatin-4 isoform X2

      Conserved Domains (1) summary
      pfam08232
      Location:64 → 188
      Striatin; Striatin family

    2. XM_063261295.1 → XP_063117365.1  striatin-4 isoform X1

      UniProtKB/TrEMBL
      A0A8I6AK86, F1M6V8

    RNA

    1. XR_010051831.1 RNA Sequence

    Nucleotide Protein Strain
    Heading Accession and Version

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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