Golgb1 golgin B1 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Golgb1provided by RGD
Official Full Name: golgin B1provided by RGD
Primary source: RGD:708429
See related: EnsemblRapid:ENSRNOG00000030314 AllianceGenome:RGD:708429
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary: Involved in chondrocyte proliferation. Predicted to be located in Golgi apparatus. Predicted to be active in cis-Golgi network and endoplasmic reticulum-Golgi intermediate compartment. Used to study osteochondrodysplasia. Orthologous to human GOLGB1 (golgin B1). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in Kidney (RPKM 159.9), Lung (RPKM 106.7) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 11q21

Exon count:: 25

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	11	NC_086029.1 (77348573..77406165, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	11	NC_051346.1 (63843179..63900665, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	11	NC_005110.4 (66761646..66819115, complement)

Chromosome 11 - NC_086029.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Ethanol-induced Golgi disassembly was associated with de-dimerization of the largest Golgi matrix protein giantin, along with impaired transport of selected hepatic proteins.
Title: Giantin Is Required for Post-Alcohol Recovery of Golgi in Liver Cells.
giantin plays a pivotal role in coordinated production of aggrecan, link protein and type XI collagen in chondrocytes.
Title: Giantin is required for coordinated production of aggrecan, link protein and type XI collagen during chondrogenesis.
concluded that mutation of the Golgb1 gene is responsible for the phenotypic characteristics including osteochondrodysplasia of ocd/ocd, and that giantin plays a pivotal role in multiple aspects of chondrogenesis
Title: Insertional mutation in the Golgb1 gene is associated with osteochondrodysplasia and systemic edema in the OCD rat.

Submit: New GeneRIF Correction

General gene information

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Gene Ontology Provided by RGD

Process	Evidence Code	Pubs
involved_in chondrocyte proliferation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in protein localization to pericentriolar material	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in Golgi apparatus	ISO Inferred from Sequence Orthology more info
is_active_in cis-Golgi network	IBA Inferred from Biological aspect of Ancestor more info
located_in cis-Golgi network	ISO Inferred from Sequence Orthology more info
is_active_in endoplasmic reticulum-Golgi intermediate compartment	IBA Inferred from Biological aspect of Ancestor more info
located_in endoplasmic reticulum-Golgi intermediate compartment	ISO Inferred from Sequence Orthology more info
located_in membrane	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: golgin subfamily B member 1

Names: Golgin subfamily B member 1; golgi autoantigen, golgin subfamily b, macrogolgin 1; golgi-associated protein GCP360; golgin B1, golgi integral membrane protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_138885.2 → NP_620240.2 golgin subfamily B member 1

Status: PROVISIONAL

Source sequence(s)

JAXUCZ010000011

UniProtKB/TrEMBL

A6IRA0, G3V6A8, Q63714

Related

ENSRNOP00000069873.3, ENSRNOT00000083152.3

Conserved Domains (3) summary

COG1196
Location:1298 → 2128

Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]

PRK00252
Location:45 → 114

alaS; alanyl-tRNA synthetase; Reviewed

TIGR02168
Location:679 → 1582

SMC_prok_B; chromosome segregation protein SMC, common bacterial type

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086029.1 Reference GRCr8

Range

77348573..77406165 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_017597867.3 → XP_017453356.1 golgin subfamily B member 1 isoform X4

UniProtKB/TrEMBL

A6IRA0, G3V6A8, Q63714

Conserved Domains (3) summary

COG1196
Location:1298 → 2128

Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]

PRK00252
Location:45 → 114

alaS; alanyl-tRNA synthetase; Reviewed

TIGR02168
Location:679 → 1582

SMC_prok_B; chromosome segregation protein SMC, common bacterial type
XM_008768700.4 → XP_008766922.1 golgin subfamily B member 1 isoform X3

UniProtKB/TrEMBL

Q63714

Conserved Domains (3) summary

COG1196
Location:1333 → 2163

Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]

TIGR02168
Location:189 → 922

SMC_prok_B; chromosome segregation protein SMC, common bacterial type

pfam10211
Location:1137 → 1203

Ax_dynein_light; Axonemal dynein light chain
XM_008768699.4 → XP_008766921.1 golgin subfamily B member 1 isoform X2

UniProtKB/TrEMBL

Q63714

Conserved Domains (3) summary

COG1196
Location:1334 → 2164

Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]

TIGR02168
Location:715 → 1618

SMC_prok_B; chromosome segregation protein SMC, common bacterial type

pfam10211
Location:1138 → 1204

Ax_dynein_light; Axonemal dynein light chain
XM_006248379.5 → XP_006248441.1 golgin subfamily B member 1 isoform X1

See identical proteins and their annotated locations for XP_006248441.1

UniProtKB/TrEMBL

A0A8I5ZUB6

Conserved Domains (4) summary

COG1196
Location:1339 → 2169

Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]

PRK00252
Location:45 → 114

alaS; alanyl-tRNA synthetase; Reviewed

PRK12704
Location:63 → 181

PRK12704; phosphodiesterase; Provisional

TIGR02168
Location:720 → 1623

SMC_prok_B; chromosome segregation protein SMC, common bacterial type
XM_063270269.1 → XP_063126339.1 golgin subfamily B member 1 isoform X4

UniProtKB/TrEMBL

A6IRA0, G3V6A8, Q63714
XM_063270268.1 → XP_063126338.1 golgin subfamily B member 1 isoform X3

UniProtKB/TrEMBL

Q63714
XM_063270265.1 → XP_063126335.1 golgin subfamily B member 1 isoform X2

UniProtKB/TrEMBL

Q63714
XM_006248380.5 → XP_006248442.1 golgin subfamily B member 1 isoform X1

See identical proteins and their annotated locations for XP_006248442.1

UniProtKB/TrEMBL

A0A8I5ZUB6

Conserved Domains (4) summary

COG1196
Location:1339 → 2169

Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]

PRK00252
Location:45 → 114

alaS; alanyl-tRNA synthetase; Reviewed

PRK12704
Location:63 → 181

PRK12704; phosphodiesterase; Provisional

TIGR02168
Location:720 → 1623

SMC_prok_B; chromosome segregation protein SMC, common bacterial type
XM_063270267.1 → XP_063126337.1 golgin subfamily B member 1 isoform X3

UniProtKB/TrEMBL

Q63714
XM_063270264.1 → XP_063126334.1 golgin subfamily B member 1 isoform X1

UniProtKB/TrEMBL

A0A8I5ZUB6

Related

ENSRNOP00000003255.4, ENSRNOT00000003255.6
XM_063270270.1 → XP_063126340.1 golgin subfamily B member 1 isoform X5

UniProtKB/TrEMBL

A0A8I6AFX2
XM_008768703.4 → XP_008766925.2 golgin subfamily B member 1 isoform X6

UniProtKB/TrEMBL

A0A8I5ZUB6, Q63714