Gpd1 glycerol-3-phosphate dehydrogenase 1 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Gpd1provided by RGD
Official Full Name: glycerol-3-phosphate dehydrogenase 1provided by RGD
Primary source: RGD:621381
See related: EnsemblRapid:ENSRNOG00000056457 AllianceGenome:RGD:621381
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: GPDH; Gpd3
Summary: Enables NAD binding activity and glycerol-3-phosphate dehydrogenase (quinone) activity. Involved in NADH oxidation; glycerol-3-phosphate metabolic process; and glycerolipid metabolic process. Predicted to be located in cytoplasm. Predicted to be active in cytosol. Orthologous to human GPD1 (glycerol-3-phosphate dehydrogenase 1). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in Muscle (RPKM 2232.8), Thymus (RPKM 2059.3) and 6 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 7q36

Exon count:: 8

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	7	NC_086025.1 (132722982..132730373)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	7	NC_051342.1 (130842526..130851530)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	7	NC_005106.4 (141368928..141377931)

Chromosome 7 - NC_086025.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

These results clarify the maximum rate and mechanism of superoxide production by mGPDH.
Title: A refined analysis of superoxide production by mitochondrial sn-glycerol 3-phosphate dehydrogenase.
GPDH expression was significantly increased in the hyperthyroid and decreased in the hyporthyroid status in both sexes.
Title: Glycerol-3-phosphate dehydrogenase expression and oxygen consumption in liver mitochondria of female and male rats with chronic alteration of thyroid status.
high efficiency of mGPDH-dependent ROS production in mammalian mitochondria with a low content of mGPDH and suggest its endogenous inhibition in BAT.
Title: High efficiency of ROS production by glycerophosphate dehydrogenase in mammalian mitochondria.
Restricted from round spermatids to early elongating spermatids. Delayed in postmeiotic germ cells, restricted from late elongating spermatids to mature spermatids. Expressed by testis-specific promoter from haploid sperm in stage-specific manner.
Title: Testis-specific expression of rat mitochondrial glycerol-3-phosphate dehydrogenase in haploid male germ cells.
Rat liver GPDH activity could serve as a useful marker for evaluation of hyperthyroid and hypothyroid status in Lewis rats.
Title: Influence of chronically altered thyroid status on the activity of liver mitochondrial glycerol-3-phosphate dehydrogenase in female inbred lewis rats.
Gpd3 was found in FOG I and FOG II muscle fibers.
Title: Nitric oxide synthase II in rat skeletal muscles.
glycerol-3-phosphate dehydrogenase, fatty acid synthase, and acetyl-coa carboxylase mRNA levels are upregulated by glucose, which requires glutamine, and glucosamine
Title: Role of hexosamine biosynthesis in glucose-mediated up-regulation of lipogenic enzyme mRNA levels: effects of glucose, glutamine, and glucosamine on glycerophosphate dehydrogenase, fatty acid synthase, and acetyl-CoA carboxylase mRNA levels.

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

Gpd1 (e-PCR), detects polymorphism
- UniSTS:527364

RH127433 (e-PCR)
- UniSTS:210743

22.MMHAP28FLH1.seq (e-PCR)
- UniSTS:123565

BF399697 (e-PCR)
- UniSTS:247763

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables NAD binding	IDA Inferred from Direct Assay more info	PubMed
enables NAD binding	IEA Inferred from Electronic Annotation more info
enables glycerol-3-phosphate dehydrogenase (NAD+) activity	IEA Inferred from Electronic Annotation more info
enables glycerol-3-phosphate dehydrogenase (quinone) activity	IDA Inferred from Direct Assay more info	PubMed
enables protein homodimerization activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in NADH metabolic process	IDA Inferred from Direct Assay more info	PubMed
involved_in NADH oxidation	IBA Inferred from Biological aspect of Ancestor more info
involved_in NADH oxidation	IDA Inferred from Direct Assay more info	PubMed
involved_in NADH oxidation	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within NADH oxidation	ISO Inferred from Sequence Orthology more info
involved_in carbohydrate metabolic process	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within cellular response to cAMP	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within cellular response to tumor necrosis factor	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within gluconeogenesis	ISO Inferred from Sequence Orthology more info
involved_in glycerol-3-phosphate catabolic process	IEA Inferred from Electronic Annotation more info
involved_in glycerol-3-phosphate metabolic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in glycerol-3-phosphate metabolic process	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within glycerol-3-phosphate metabolic process	ISO Inferred from Sequence Orthology more info
involved_in glycerolipid metabolic process	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within glycerophosphate shuttle	ISO Inferred from Sequence Orthology more info
involved_in glycerophosphate shuttle	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within positive regulation of glycolytic process	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
is_active_in cytosol	IBA Inferred from Biological aspect of Ancestor more info
is_active_in cytosol	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: glycerol-3-phosphate dehydrogenase [NAD(+)], cytoplasmic

Names: GPD-C; GPDH-C; glycerol 3-phosphate dehydrogenase; glycerol-3-phosphate dehydrogenase 1 (soluble); glycerol-3-phosphate dehydrogenase [NAD+], cytoplasmic

NP_071551.2

EC 1.1.1.8

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_022215.2 → NP_071551.2 glycerol-3-phosphate dehydrogenase [NAD(+)], cytoplasmic

See identical proteins and their annotated locations for NP_071551.2

Status: PROVISIONAL

Source sequence(s)

BC088396

UniProtKB/Swiss-Prot

O35077, Q5I0F4

UniProtKB/TrEMBL

A0A8I6AA38, A6KCH1

Related

ENSRNOP00000074647.1, ENSRNOT00000087662.3

Conserved Domains (3) summary

TIGR03376
Location:5 → 342

glycerol3P_DH; glycerol-3-phosphate dehydrogenase (NAD(+))

pfam01210
Location:5 → 172

NAD_Gly3P_dh_N; NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus

pfam07479
Location:194 → 335

NAD_Gly3P_dh_C; NAD-dependent glycerol-3-phosphate dehydrogenase C-terminus