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    Commd4 COMM domain containing 4 [ Mus musculus (house mouse) ]

    Gene ID: 66199, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Commd4provided by MGI
    Official Full Name
    COMM domain containing 4provided by MGI
    Primary source
    MGI:MGI:1913449
    See related
    Ensembl:ENSMUSG00000032299 AllianceGenome:MGI:1913449
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    1110039H05Rik
    Summary
    Predicted to be involved in signal transduction. Predicted to be located in cytosol; intracellular membrane-bounded organelle; and plasma membrane. Orthologous to human COMMD4 (COMM domain containing 4). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Ubiquitous expression in thymus adult (RPKM 54.1), placenta adult (RPKM 51.9) and 28 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Commd4 in Genome Data Viewer
    Location:
    9 B; 9 30.89 cM
    Exon count:
    8
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 9 NC_000075.7 (57062319..57065633, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 9 NC_000075.6 (57155035..57158349, complement)

    Chromosome 9 - NC_000075.7Genomic Context describing neighboring genes Neighboring gene CapStarr-seq enhancer MGSCv37_chr9:56978348-56978531 Neighboring gene STARR-positive B cell enhancer ABC_E3832 Neighboring gene mannosidase, alpha, class 2C, member 1, opposite strand Neighboring gene mannosidase, alpha, class 2C, member 1 Neighboring gene CapStarr-seq enhancer MGSCv37_chr9:56995851-56996034 Neighboring gene STARR-positive B cell enhancer ABC_E5070 Neighboring gene nei endonuclease VIII-like 1 (E. coli) Neighboring gene CapStarr-seq enhancer MGSCv37_chr9:57006119-57006228 Neighboring gene RIKEN cDNA 1700041C23 gene Neighboring gene STARR-seq mESC enhancer starr_24219 Neighboring gene predicted gene, 46115

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Characterization of the piRNA complex from rat testes. Lau NC, et al. Science, 2006 Jul 21. PMID 16778019
    2. Libraries enriched for alternatively spliced exons reveal splicing patterns in melanocytes and melanomas. Watahiki A, et al. Nat Methods, 2004 Dec. PMID 15782199
    3. BraInMap Elucidates the Macromolecular Connectivity Landscape of Mammalian Brain. Pourhaghighi R, et al. Cell Syst, 2020 Apr 22. PMID 32325033, Free PMC Article
    4. A conditional knockout resource for the genome-wide study of mouse gene function. Skarnes WC, et al. Nature, 2011 Jun 15. PMID 21677750, Free PMC Article
    5. Normalization and subtraction: two approaches to facilitate gene discovery. Bonaldo MF, et al. Genome Res, 1996 Sep. PMID 8889548

    See all (16) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (1) 

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables molecular_function ND
    No biological Data available
    more info
    		  
    Process Evidence Code Pubs
    involved_in biological_process ND
    No biological Data available
    more info
    		  
    involved_in signal transduction IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cytosol IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in intracellular membrane-bounded organelle ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in plasma membrane ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    COMM domain-containing protein 4

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_025417.2 → NP_079693.1  COMM domain-containing protein 4

      See identical proteins and their annotated locations for NP_079693.1

      Status: PROVISIONAL

      Source sequence(s)
      AK004174
      Consensus CDS
      CCDS40647.1
      UniProtKB/Swiss-Prot
      Q9CQ02
      UniProtKB/TrEMBL
      A0A1L1SVC7
      Related
      ENSMUSP00000069078.8, ENSMUST00000065358.9
      Conserved Domains (1) summary
      cd04752
      Location:25 → 198
      Commd4; COMM_Domain containing protein 4. The COMM Domain is found at the C-terminus of a variety of proteins; presumably all COMM_Domain containing proteins are located in the nucleus and the COMM domain plays a role in protein-protein interactions. Several ...

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000075.7 Reference GRCm39 C57BL/6J

      Range
      57062319..57065633 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006511343.2 → XP_006511406.1  COMM domain-containing protein 4 isoform X1

      See identical proteins and their annotated locations for XP_006511406.1

      UniProtKB/TrEMBL
      A0A1L1SVC7
      Related
      ENSMUSP00000151102.2, ENSMUST00000214640.2
      Conserved Domains (1) summary
      cl06336
      Location:26 → 176
      Commd; COMM_Domain, a family of domains found at the C-terminus of HCarG, the copper metabolism gene MURR1 product, and related proteins. Presumably all COMM_Domain containing proteins are located in the nucleus and the COMM domain plays a role in ...

    RNA

    1. XR_003947971.1 RNA Sequence

    2. XR_379435.2 RNA Sequence

    3. XR_003947970.1 RNA Sequence

    4. XR_003947969.1 RNA Sequence

    5. XR_379436.3 RNA Sequence

    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9CQ02.1 GenPept UniProtKB/Swiss-Prot:Q9CQ02

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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