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    Scart1 scavenger receptor family member expressed on T cells 1 [ Mus musculus (house mouse) ]

    Gene ID: 244233, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Scart1provided by MGI
    Official Full Name
    scavenger receptor family member expressed on T cells 1provided by MGI
    Primary source
    MGI:MGI:2443796
    See related
    Ensembl:ENSMUSG00000025461 AllianceGenome:MGI:2443796
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Cd163l1; B430307C05; E430002D04Rik
    Summary
    Located in plasma membrane. Orthologous to human SCART1 (scavenger receptor family member expressed on T cells 1). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in thymus adult (RPKM 1.6), lung adult (RPKM 0.8) and 11 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Scart1 in Genome Data Viewer
    Location:
    7 F4; 7 85.26 cM
    Exon count:
    15
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 7 NC_000073.7 (139777131..139811058)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 7 NC_000073.6 (140197218..140231145)

    Chromosome 7 - NC_000073.7Genomic Context describing neighboring genes Neighboring gene olfactory receptor family 6 subfamily AE member 1 Neighboring gene STARR-seq mESC enhancer starr_20448 Neighboring gene olfactory receptor enhancer Fourni Neighboring gene olfactory receptor family 6 subfamily F member 2 Neighboring gene olfactory receptor family 6 subfamily B member 13 Neighboring gene scavenger receptor family member expressed on T cells 2 Neighboring gene predicted pseudogene 6314

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Elevated numbers of SCART1+ gammadelta T cells in skin inflammation and inflammatory bowel disease. Fink DR, et al. Mol Immunol, 2010 May. PMID 20381152
    2. Cloning and characterization of SCART1, a novel scavenger receptor cysteine-rich type I transmembrane molecule. Holm D, et al. Mol Immunol, 2009 May. PMID 19297026
    3. SCART scavenger receptors identify a novel subset of adult gammadelta T cells. Kisielow J, et al. J Immunol, 2008 Aug 1. PMID 18641307
    4. Normalization and subtraction: two approaches to facilitate gene discovery. Bonaldo MF, et al. Genome Res, 1996 Sep. PMID 8889548
    5. Antisense transcription in the mammalian transcriptome. Katayama S, et al. Science, 2005 Sep 2. PMID 16141073

    See all (13) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Results show that SCART1 is a novel gammadelta T cell marker and it is therefore likely that SCART1 plays a role in the immune response.
      Title: Elevated numbers of SCART1+ gammadelta T cells in skin inflammation and inflammatory bowel disease.
    2. described two novel surface receptors, SCART1 and SCART2
      Title: SCART scavenger receptors identify a novel subset of adult gammadelta T cells.
    3. mSCART1 is highly related to the WC1 family of the SRCR superfamily.
      Title: Cloning and characterization of SCART1, a novel scavenger receptor cysteine-rich type I transmembrane molecule.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (3) 

    General gene information

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    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables molecular_function ND
    No biological Data available
    more info
    		  
    Process Evidence Code Pubs
    involved_in biological_process ND
    No biological Data available
    more info
    		  
    Component Evidence Code Pubs
    located_in brush border ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in plasma membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    scavenger receptor cysteine-rich domain-containing protein SCART1
    Names
    CD163 molecule-like 1
    scavenger receptor cysteine-rich type 1 protein CD163c-alpha

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_172909.4 → NP_766497.3  scavenger receptor cysteine-rich domain-containing protein SCART1 precursor

      See identical proteins and their annotated locations for NP_766497.3

      Status: VALIDATED

      Source sequence(s)
      AC107839
      Consensus CDS
      CCDS40174.1
      UniProtKB/TrEMBL
      A0A1B0GSB0, Q8CGY7
      Related
      ENSMUSP00000081497.7, ENSMUST00000084460.7
      Conserved Domains (2) summary
      smart00202
      Location:546 → 646
      SR; Scavenger receptor Cys-rich
      pfam00530
      Location:446 → 541
      SRCR; Scavenger receptor cysteine-rich domain

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000073.7 Reference GRCm39 C57BL/6J

      Range
      139777131..139811058
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017322262.2 → XP_017177751.1  scavenger receptor cysteine-rich domain-containing protein SCART1 isoform X5

      UniProtKB/TrEMBL
      A0A1B0GSB0
      Conserved Domains (2) summary
      smart00202
      Location:430 → 530
      SR; Scavenger receptor Cys-rich
      pfam00530
      Location:330 → 425
      SRCR; Scavenger receptor cysteine-rich domain

    2. XM_017322257.2 → XP_017177746.1  scavenger receptor cysteine-rich domain-containing protein SCART1 isoform X1

      UniProtKB/TrEMBL
      A0A1B0GSB0
      Conserved Domains (2) summary
      smart00202
      Location:546 → 646
      SR; Scavenger receptor Cys-rich
      pfam00530
      Location:446 → 541
      SRCR; Scavenger receptor cysteine-rich domain

    3. XM_017322258.2 → XP_017177747.1  scavenger receptor cysteine-rich domain-containing protein SCART1 isoform X2

      UniProtKB/TrEMBL
      A0A1B0GSB0, Q8CGY7
      Conserved Domains (2) summary
      smart00202
      Location:546 → 646
      SR; Scavenger receptor Cys-rich
      pfam00530
      Location:446 → 541
      SRCR; Scavenger receptor cysteine-rich domain

    4. XM_017322260.2 → XP_017177749.1  scavenger receptor cysteine-rich domain-containing protein SCART1 isoform X4

      UniProtKB/TrEMBL
      A0A1B0GSB0
      Conserved Domains (2) summary
      smart00202
      Location:546 → 646
      SR; Scavenger receptor Cys-rich
      pfam00530
      Location:446 → 541
      SRCR; Scavenger receptor cysteine-rich domain

    5. XM_017322259.2 → XP_017177748.1  scavenger receptor cysteine-rich domain-containing protein SCART1 isoform X3

      UniProtKB/TrEMBL
      A0A1B0GSB0
      Conserved Domains (2) summary
      smart00202
      Location:546 → 646
      SR; Scavenger receptor Cys-rich
      pfam00530
      Location:446 → 541
      SRCR; Scavenger receptor cysteine-rich domain

    6. XM_017322261.2 → XP_017177750.1  scavenger receptor cysteine-rich domain-containing protein SCART1 isoform X5

      UniProtKB/TrEMBL
      A0A1B0GSB0
      Conserved Domains (2) summary
      smart00202
      Location:430 → 530
      SR; Scavenger receptor Cys-rich
      pfam00530
      Location:330 → 425
      SRCR; Scavenger receptor cysteine-rich domain
    Nucleotide Protein Strain
    Heading Accession and Version

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