Gucy2d guanylate cyclase 2d [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Gucy2dprovided by MGI
Official Full Name: guanylate cyclase 2dprovided by MGI
Primary source: MGI:MGI:106030
See related: Ensembl:ENSMUSG00000074003 AllianceGenome:MGI:106030
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Summary: Enables odorant binding activity and olfactory receptor activity. Involved in several processes, including detection of chemical stimulus involved in sensory perception of smell; olfactory learning; and positive regulation of cGMP-mediated signaling. Predicted to be located in non-motile cilium. Predicted to be active in plasma membrane. Is expressed in spinal cord. [provided by Alliance of Genome Resources, Dec 2024]
Expression: Low expression observed in reference dataset See more
Orthologs: rat all
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Genomic context

Location:: 7 E1; 7 53.86 cM

Exon count:: 19

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	7	NC_000073.7 (98089623..98126685)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	7	NC_000073.6 (98440416..98477478)

Chromosome 7 - NC_000073.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Sensory neurons expressing the atypical olfactory receptor guanylyl cyclase D are required for the acquisition of odor preferences by mice in diverse social contexts.
Title: Sensory neurons expressing the atypical olfactory receptor guanylyl cyclase D are required for the acquisition of odor preferences by mice in diverse social contexts.
the S248W mutation contributes to Leber congenital amaurosis 1 by hampering the expression, processing, and/or cellular transport of GUCY2D, rather than its enzymatic properties.
Title: Functional study of two biochemically unusual mutations in GUCY2D Leber congenital amaurosis expressed via adenoassociated virus vector in mouse retinas.
This mouse model provides the first direct biochemical and physiological in vivo evidence for the Arg(838) substitutions in RetGC1 being the culprit behind the pathogenesis of the CORD6 congenital blindness.
Title: The R838S Mutation in Retinal Guanylyl Cyclase 1 (RetGC1) Alters Calcium Sensitivity of cGMP Synthesis in the Retina and Causes Blindness in Transgenic Mice.
Genetic evidence for a Nrp2-Sema3f interaction as a determinant of the wiring of axons of gucy2d+ neurons into the unusual configuration of necklace glomeruli.
Title: Axonal wiring of guanylate cyclase-D-expressing olfactory neurons is dependent on neuropilin 2 and semaphorin 3F.
Mg(2+) binding to GCAPs is critical for setting the actual dynamic range of RetGC regulation by GCAPs at physiological levels of free Ca(2+)
Title: Guanylyl cyclase-activating proteins (GCAPs) are Ca2+/Mg2+ sensors: implications for photoreceptor guanylyl cyclase (RetGC) regulation in mammalian photoreceptors.

Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (4) 1 citation
Targeted (3) 1 citation

General gene information

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Markers

RH133869 (e-PCR)
- UniSTS:217152

Gucy2d (e-PCR), detects polymorphism
- UniSTS:525453

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables ATP binding	IEA Inferred from Electronic Annotation more info
enables guanylate cyclase activity	IBA Inferred from Biological aspect of Ancestor more info
enables guanylate cyclase activity	ISO Inferred from Sequence Orthology more info
enables guanylate cyclase activity	ISS Inferred from Sequence or Structural Similarity more info
enables natriuretic peptide receptor activity	ISO Inferred from Sequence Orthology more info
enables odorant binding	IMP Inferred from Mutant Phenotype more info	PubMed
enables olfactory receptor activity	IMP Inferred from Mutant Phenotype more info	PubMed
enables peptide receptor activity	IBA Inferred from Biological aspect of Ancestor more info
enables protein kinase activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in cGMP biosynthetic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in cGMP biosynthetic process	ISO Inferred from Sequence Orthology more info
involved_in cGMP biosynthetic process	ISS Inferred from Sequence or Structural Similarity more info
involved_in detection of carbon dioxide	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in detection of chemical stimulus involved in sensory perception of smell	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in intracellular signal transduction	IEA Inferred from Electronic Annotation more info
involved_in olfactory behavior	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in olfactory learning	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of cGMP-mediated signaling	IDA Inferred from Direct Assay more info	PubMed
involved_in receptor guanylyl cyclase signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
involved_in receptor guanylyl cyclase signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in receptor guanylyl cyclase signaling pathway	ISS Inferred from Sequence or Structural Similarity more info
involved_in sensory perception of smell	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in ciliary membrane	IEA Inferred from Electronic Annotation more info
located_in non-motile cilium	ISO Inferred from Sequence Orthology more info
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: guanylate cyclase D

Names: guanylyl cyclase 2d; guanylyl cyclase D; olfactory guanylyl cyclase GC-D

NP_001124165.1

EC 4.6.1.2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001130693.3 → NP_001124165.1 guanylate cyclase D precursor

Status: VALIDATED

Source sequence(s)

AC111084, AC115069

Consensus CDS

CCDS85343.1

UniProtKB/Swiss-Prot

A0A0U1RPR8

UniProtKB/TrEMBL

F6VFS9

Related

ENSMUSP00000146093.2, ENSMUST00000206435.2

Conserved Domains (3) summary

smart00044
Location:855 → 1044

CYCc; Adenylyl- / guanylyl cyclase, catalytic domain

cd14043
Location:554 → 818

PK_GC-2D; Pseudokinase domain of the membrane Guanylate Cyclase receptor, GC-2D

cd06371
Location:71 → 445

PBP1_sensory_GC_DEF-like; ligand-binding domain of membrane guanylyl cyclases (GC-D, GC-E, and GC-F) that are specifically expressed in sensory tissues

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000073.7 Reference GRCm39 C57BL/6J

Range

98089623..98126685

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GenBank, FASTA, Sequence Viewer (Graphics)

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

NM_001034890.1: Suppressed sequence

Description

NM_001034890.1: This RefSeq was permanently suppressed because currently there is insufficient support for the transcript and the protein.