Dcdc2a doublecortin domain containing 2a [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Dcdc2aprovided by MGI
Official Full Name: doublecortin domain containing 2aprovided by MGI
Primary source: MGI:MGI:2652818
See related: Ensembl:ENSMUSG00000035910 AllianceGenome:MGI:2652818
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: RU2; Dcdc2; AW492955
Summary: This gene encodes a member of the doublecortin family. The protein encoded by this gene contains two doublecortin domains. The doublecortin domain has been demonstrated to bind tubulin and enhance microtubule polymerization. Alternatively spliced transcript variants encoding distinct isoforms have been found for this gene. [provided by RefSeq, Sep 2010]
Expression: Low expression observed in reference dataset See more
Orthologs: human all
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Genomic context

Location:: 13 A3.1; 13 10.89 cM

Exon count:: 14

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	13	NC_000079.7 (25239126..25394689)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	13	NC_000079.6 (25055273..25210706)

Chromosome 13 - NC_000079.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

DCDC2 inhibits hepatic stellate cell activation and ameliorates CCl4-induced liver fibrosis by suppressing Wnt/beta-catenin signaling.
Title: DCDC2 inhibits hepatic stellate cell activation and ameliorates CCl(4)-induced liver fibrosis by suppressing Wnt/β-catenin signaling.
Dcdc2 KOs displayed deficits on the Pairwise Discrimination task specifically as motion was added to visual stimuli.
Title: Evaluation of visual motion perception ability in mice with knockout of the dyslexia candidate susceptibility gene Dcdc2.
Behavioral results revealed deficits in rapid auditory processing, working memory and reference memory in Dcdc2(del2/del2) mice when compared with matched wild types.
Title: Mutation of Dcdc2 in mice leads to impairments in auditory processing and memory ability.
Results link the function of the dyslexia-associated gene Dcdc2 to spike timing through activity of N-methyl-D-aspartate receptor (NMDAR)
Title: The dyslexia-associated gene DCDC2 is required for spike-timing precision in mouse neocortex.
These results indicate that Dcdc2 is not required for neurogenesis, neuronal migration or differentiation in mice, but may have partial functional redundancy with doublecortin.
Title: Dcdc2 knockout mice display exacerbated developmental disruptions following knockdown of doublecortin.
heterozygous and homozygous mutations of Dcdc2 result in persistent visuo-spatial memory deficits, as well as visual discrimination and long-term memory deficits
Title: Mutation of the dyslexia-associated gene Dcdc2 impairs LTM and visuo-spatial performance in mice.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (2)
Targeted (2) 1 citation

General gene information

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Markers

AW492955 (e-PCR)
- UniSTS:180506

38.MMHAP37FLE5.seq (e-PCR)
- UniSTS:124277

D13Mit58 (e-PCR), detects polymorphism
- UniSTS:127156

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables kinesin binding	ISO Inferred from Sequence Orthology more info
enables molecular_function	ND No biological Data available more info

Process	Evidence Code	Pubs
involved_in cilium assembly	IBA Inferred from Biological aspect of Ancestor more info
involved_in cilium assembly	ISO Inferred from Sequence Orthology more info
involved_in cilium assembly	ISS Inferred from Sequence or Structural Similarity more info
involved_in dendrite morphogenesis	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within dendrite morphogenesis	IGI Inferred from Genetic Interaction more info	PubMed
involved_in intracellular signal transduction	IEA Inferred from Electronic Annotation more info
involved_in neuron migration	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within neuron migration	IGI Inferred from Genetic Interaction more info	PubMed
involved_in neuron migration	ISO Inferred from Sequence Orthology more info
involved_in neuron migration	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of_or_within neuronal action potential	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of Wnt signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in regulation of Wnt signaling pathway	ISS Inferred from Sequence or Structural Similarity more info
involved_in regulation of cilium assembly	IBA Inferred from Biological aspect of Ancestor more info
involved_in regulation of cilium assembly	ISO Inferred from Sequence Orthology more info
involved_in regulation of cilium assembly	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of sensory perception of sound	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in sensory perception of sound	ISO Inferred from Sequence Orthology more info
involved_in sensory perception of sound	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of_or_within synaptic transmission, glutamatergic	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of visual learning	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within visual learning	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
is_active_in axoneme	IBA Inferred from Biological aspect of Ancestor more info
located_in axoneme	ISO Inferred from Sequence Orthology more info
located_in axoneme	ISS Inferred from Sequence or Structural Similarity more info
located_in centriolar satellite	ISO Inferred from Sequence Orthology more info
located_in cilium	ISO Inferred from Sequence Orthology more info
located_in cilium	ISS Inferred from Sequence or Structural Similarity more info
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
located_in cytoplasm	ISS Inferred from Sequence or Structural Similarity more info
located_in cytosol	ISO Inferred from Sequence Orthology more info
is_active_in kinocilium	IBA Inferred from Biological aspect of Ancestor more info
located_in kinocilium	ISO Inferred from Sequence Orthology more info
located_in kinocilium	ISS Inferred from Sequence or Structural Similarity more info
is_active_in microtubule	IBA Inferred from Biological aspect of Ancestor more info
located_in microtubule cytoskeleton	ISO Inferred from Sequence Orthology more info
is_active_in microtubule organizing center	IBA Inferred from Biological aspect of Ancestor more info
located_in mitotic spindle	ISO Inferred from Sequence Orthology more info
located_in synapse	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: doublecortin domain-containing protein 2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001195617.1 → NP_001182546.1 doublecortin domain-containing protein 2 isoform 2

See identical proteins and their annotated locations for NP_001182546.1

Status: REVIEWED

Description

Transcript Variant: This variant (2) lacks several 3' exons, but has a unique 3' exon, as compared to variant 1. The resulting isoform (2) has a shorter and distinct C-terminus, as compared to isoform 1. The isoform 2 retains two doublecortin domains.

Source sequence(s)

BC045136

Consensus CDS

CCDS56873.1

UniProtKB/Swiss-Prot

Q5DU00

Related

ENSMUSP00000047641.9, ENSMUST00000036932.15

Conserved Domains (2) summary

cd01617
Location:17 → 96

DCX; Ubiquitin-like domain of DCX

smart00537
Location:134 → 221

DCX; Domain in the Doublecortin (DCX) gene product
NM_177577.3 → NP_808245.2 doublecortin domain-containing protein 2 isoform 1

See identical proteins and their annotated locations for NP_808245.2

Status: REVIEWED

Description

Transcript Variant: This variant (1) is the longer transcript and encodes the longer isoform (1).

Source sequence(s)

AK220370, AL589735, AW492955, BC045136

Consensus CDS

CCDS26386.2

UniProtKB/Swiss-Prot

Q5DU00, Q5SZU0, Q80Y99

UniProtKB/TrEMBL

R4GML1

Related

ENSMUSP00000063650.7, ENSMUST00000069614.7

Conserved Domains (4) summary

PRK08163
Location:69 → 138

PRK08163; 3-hydroxybenzoate 6-monooxygenase

TIGR00927
Location:246 → 466

2A1904; K+-dependent Na+/Ca+ exchanger

cd17152
Location:138 → 217

DCX2_DCDC2; Doublecortin-like domain 2 found in doublecortin domain-containing protein 2 (DCDC2)

cl28922
Location:17 → 96

Ubiquitin_like_fold; Beta-grasp ubiquitin-like fold

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000079.7 Reference GRCm39 C57BL/6J

Range

25239126..25394689

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_011244294.4 → XP_011242596.1 doublecortin domain-containing protein 2 isoform X1

See identical proteins and their annotated locations for XP_011242596.1

UniProtKB/Swiss-Prot

Q5DU00, Q5SZU0, Q80Y99

Conserved Domains (4) summary

PRK08163
Location:69 → 138

PRK08163; 3-hydroxybenzoate 6-monooxygenase

TIGR00927
Location:246 → 480

2A1904; K+-dependent Na+/Ca+ exchanger

cd17152
Location:138 → 217

DCX2_DCDC2; Doublecortin-like domain 2 found in doublecortin domain-containing protein 2 (DCDC2)

cl28922
Location:17 → 96

Ubiquitin_like_fold; Beta-grasp ubiquitin-like fold
XM_006516604.4 → XP_006516667.1 doublecortin domain-containing protein 2 isoform X2

See identical proteins and their annotated locations for XP_006516667.1

UniProtKB/Swiss-Prot

Q5DU00, Q5SZU0, Q80Y99

UniProtKB/TrEMBL

R4GML1

Conserved Domains (4) summary

PRK08163
Location:69 → 138

PRK08163; 3-hydroxybenzoate 6-monooxygenase

TIGR00927
Location:246 → 466

2A1904; K+-dependent Na+/Ca+ exchanger

cd17152
Location:138 → 217

DCX2_DCDC2; Doublecortin-like domain 2 found in doublecortin domain-containing protein 2 (DCDC2)

cl28922
Location:17 → 96

Ubiquitin_like_fold; Beta-grasp ubiquitin-like fold
XM_011244291.3 → XP_011242593.1 doublecortin domain-containing protein 2 isoform X1

See identical proteins and their annotated locations for XP_011242593.1

UniProtKB/Swiss-Prot

Q5DU00, Q5SZU0, Q80Y99

Conserved Domains (4) summary

PRK08163
Location:69 → 138

PRK08163; 3-hydroxybenzoate 6-monooxygenase

TIGR00927
Location:246 → 480

2A1904; K+-dependent Na+/Ca+ exchanger

cd17152
Location:138 → 217

DCX2_DCDC2; Doublecortin-like domain 2 found in doublecortin domain-containing protein 2 (DCDC2)

cl28922
Location:17 → 96

Ubiquitin_like_fold; Beta-grasp ubiquitin-like fold
XM_036157923.1 → XP_036013816.1 doublecortin domain-containing protein 2 isoform X2

UniProtKB/Swiss-Prot

Q5DU00, Q5SZU0, Q80Y99

UniProtKB/TrEMBL

R4GML1

Conserved Domains (4) summary

PRK08163
Location:69 → 138

PRK08163; 3-hydroxybenzoate 6-monooxygenase

TIGR00927
Location:246 → 466

2A1904; K+-dependent Na+/Ca+ exchanger

cd17152
Location:138 → 217

DCX2_DCDC2; Doublecortin-like domain 2 found in doublecortin domain-containing protein 2 (DCDC2)

cl28922
Location:17 → 96

Ubiquitin_like_fold; Beta-grasp ubiquitin-like fold
XM_011244292.1 → XP_011242594.1 doublecortin domain-containing protein 2 isoform X1

See identical proteins and their annotated locations for XP_011242594.1

UniProtKB/Swiss-Prot

Q5DU00, Q5SZU0, Q80Y99

Conserved Domains (4) summary

PRK08163
Location:69 → 138

PRK08163; 3-hydroxybenzoate 6-monooxygenase

TIGR00927
Location:246 → 480

2A1904; K+-dependent Na+/Ca+ exchanger

cd17152
Location:138 → 217

DCX2_DCDC2; Doublecortin-like domain 2 found in doublecortin domain-containing protein 2 (DCDC2)

cl28922
Location:17 → 96

Ubiquitin_like_fold; Beta-grasp ubiquitin-like fold
XM_036157924.1 → XP_036013817.1 doublecortin domain-containing protein 2 isoform X2

UniProtKB/Swiss-Prot

Q5DU00, Q5SZU0, Q80Y99

UniProtKB/TrEMBL

R4GML1

Conserved Domains (4) summary

PRK08163
Location:69 → 138

PRK08163; 3-hydroxybenzoate 6-monooxygenase

TIGR00927
Location:246 → 466

2A1904; K+-dependent Na+/Ca+ exchanger

cd17152
Location:138 → 217

DCX2_DCDC2; Doublecortin-like domain 2 found in doublecortin domain-containing protein 2 (DCDC2)

cl28922
Location:17 → 96

Ubiquitin_like_fold; Beta-grasp ubiquitin-like fold
XM_036157925.1 → XP_036013818.1 doublecortin domain-containing protein 2 isoform X3

Conserved Domains (2) summary

TIGR00927
Location:111 → 343

2A1904; K+-dependent Na+/Ca+ exchanger

cl28922
Location:17 → 96

Ubiquitin_like_fold; Beta-grasp ubiquitin-like fold