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    Trpm8 transient receptor potential cation channel, subfamily M, member 8 [ Mus musculus (house mouse) ]

    Gene ID: 171382, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Trpm8provided by MGI
    Official Full Name
    transient receptor potential cation channel, subfamily M, member 8provided by MGI
    Primary source
    MGI:MGI:2181435
    See related
    Ensembl:ENSMUSG00000036251 AllianceGenome:MGI:2181435
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    CMR1; TRPP8; LTRPC6; Trp-p8; LTrpC-6
    Summary
    Enables calcium channel activity and identical protein binding activity. Involved in positive regulation of cold-induced thermogenesis. Acts upstream of or within several processes, including intracellular calcium ion homeostasis; response to cold; and thermoception. Located in external side of plasma membrane and membrane raft. Is expressed in dorsal root ganglion; inferior vagus ganglion; lumbar dorsal root ganglion; and vagus ganglion. Orthologous to human TRPM8 (transient receptor potential cation channel subfamily M member 8). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in testis adult (RPKM 2.5), CNS E18 (RPKM 0.2) and 1 other tissue See more
    Orthologs
    human all
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    Genomic context

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    See Trpm8 in Genome Data Viewer
    Location:
    1 D; 1 44.57 cM
    Exon count:
    29
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 1 NC_000067.7 (88234457..88318909)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 1 NC_000067.6 (88306735..88388853)

    Chromosome 1 - NC_000067.7Genomic Context describing neighboring genes Neighboring gene UDP glycosyltransferase 1 family, polypeptide A10 Neighboring gene UDP glucuronosyltransferase 1 family, polypeptide A9 Neighboring gene UDP glucuronosyltransferase 1 family, polypeptide A8 Neighboring gene UDP glucuronosyltransferase 1 family, polypeptide A7C Neighboring gene UDP glucuronosyltransferase 1 family, polypeptide A6B Neighboring gene UDP glucuronosyltransferase 1 family, polypeptide A6A Neighboring gene UDP glucuronosyltransferase 1 family, polypeptide A5 Neighboring gene STARR-positive B cell enhancer mm9_chr1:90112870-90113171 Neighboring gene STARR-positive B cell enhancer mm9_chr1:90113610-90113910 Neighboring gene STARR-seq mESC enhancer starr_01629 Neighboring gene STARR-positive B cell enhancer mm9_chr1:90118277-90118578 Neighboring gene UDP glucuronosyltransferase 1 family, polypeptide A2 Neighboring gene UDP glucuronosyltransferase 1 family, polypeptide A1 Neighboring gene maestro heat-like repeat family member 2A Neighboring gene STARR-positive B cell enhancer mm9_chr1:90185502-90185802 Neighboring gene STARR-positive B cell enhancer mm9_chr1:90186563-90186863 Neighboring gene STARR-positive B cell enhancer mm9_chr1:90195708-90196009 Neighboring gene Holliday junction recognition protein Neighboring gene STARR-seq mESC enhancer starr_01631 Neighboring gene STARR-seq mESC enhancer starr_01632 Neighboring gene secreted phosphoprotein 2 Neighboring gene STARR-seq mESC enhancer starr_01633 Neighboring gene predicted gene 29538 Neighboring gene predicted gene 28888

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Topical application of TRPM8 agonists accelerates skin permeability barrier recovery and reduces epidermal proliferation induced by barrier insult: role of cold-sensitive TRP receptors in epidermal permeability barrier homoeostasis. Denda M, et al. Exp Dermatol, 2010 Sep. PMID 20636355
    2. Menthol activation of corneal cool cells induces TRPM8-mediated lacrimation but not nociceptive responses in rodents. Robbins A, et al. Invest Ophthalmol Vis Sci, 2012 Oct 9. PMID 22952122, Free PMC Article
    3. Dampened neural activity and abolition of epileptic-like activity in cortical slices by active ingredients of spices. Pezzoli M, et al. Sci Rep, 2014 Oct 31. PMID 25359561, Free PMC Article
    4. N-glycosylation of TRPM8 ion channels modulates temperature sensitivity of cold thermoreceptor neurons. Pertusa M, et al. J Biol Chem, 2012 May 25. PMID 22493431, Free PMC Article
    5. Role of TRPM8 Channels in Altered Cold Sensitivity of Corneal Primary Sensory Neurons Induced by Axonal Damage. Piña R, et al. J Neurosci, 2019 Oct 9. PMID 31471469, Free PMC Article

    See all (202) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Huddling substates in mice facilitate dynamic changes in body temperature and are modulated by Shank3b and Trpm8 mutation.
      Title: Huddling substates in mice facilitate dynamic changes in body temperature and are modulated by Shank3b and Trpm8 mutation.
    2. TRPM8 affects relative "cooling and heating" of subcellular organelles in microglia in a context-dependent manner.
      Title: TRPM8 affects relative "cooling and heating" of subcellular organelles in microglia in a context-dependent manner.
    3. Separation of Oral Cooling and Warming Requires TRPM8.
      Title: Separation of Oral Cooling and Warming Requires TRPM8.
    4. [Effect of TRPM8 on pain symptom and neuronal proliferation in mice with interstitial cystitis/bladder pain syndrome].
      Title: [Effect of TRPM8 on pain symptom and neuronal proliferation in mice with interstitial cystitis/bladder pain syndrome].
    5. Loss of TRPM8 Exacerbate Herpes Simplex Keratitis Infection in Mice by Promoting the Infiltration of CD11b+ Ly6G+ Cells and Increasing the Viral Load in the Cornea.
      Title: Loss of TRPM8 Exacerbate Herpes Simplex Keratitis Infection in Mice by Promoting the Infiltration of CD11b+ Ly6G+ Cells and Increasing the Viral Load in the Cornea.
    6. Modulation of TRPM8 alters the phagocytic activity of microglia and induces changes in sub-cellular organelle functions.
      Title: Modulation of TRPM8 alters the phagocytic activity of microglia and induces changes in sub-cellular organelle functions.
    7. Characterization of TRPM8-expressing neurons in the adult mouse hypothalamus.
      Title: Characterization of TRPM8-expressing neurons in the adult mouse hypothalamus.
    8. Neuronal loss of TRPM8 leads to obesity and glucose intolerance in male mice.
      Title: Neuronal loss of TRPM8 leads to obesity and glucose intolerance in male mice.
    9. Endogenous Inflammatory Mediators Produced by Injury Activate TRPV1 and TRPA1 Nociceptors to Induce Sexually Dimorphic Cold Pain That Is Dependent on TRPM8 and GFRalpha3.
      Title: Endogenous Inflammatory Mediators Produced by Injury Activate TRPV1 and TRPA1 Nociceptors to Induce Sexually Dimorphic Cold Pain That Is Dependent on TRPM8 and GFRα3.
    10. The cold-sensing ion channel TRPM8 regulates central and peripheral clockwork and the circadian oscillations of body temperature.
      Title: The cold-sensing ion channel TRPM8 regulates central and peripheral clockwork and the circadian oscillations of body temperature.
    Submit: New GeneRIF Correction See all GeneRIFs (122)

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (5) 
    • Targeted (7)  1 citation

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC2849

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables calcium channel activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables calcium channel activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    enables identical protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables ligand-gated calcium channel activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables monoatomic ion channel activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables monoatomic ion channel activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in calcium ion transmembrane transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in calcium ion transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within calcium ion transport IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    acts_upstream_of_or_within intracellular calcium ion homeostasis IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in positive regulation of cold-induced thermogenesis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within response to cold IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    acts_upstream_of_or_within response to cold IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within response to temperature stimulus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    acts_upstream_of_or_within thermoception IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    acts_upstream_of_or_within thermoception IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in external side of plasma membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    located_in membrane raft IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in plasma membrane ISO
    Inferred from Sequence Orthology
    more info
    		 PubMed 
    located_in plasma membrane raft IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    transient receptor potential cation channel subfamily M member 8
    Names
    TRP ion channel TRPM8
    long transient receptor potential channel 6
    transient receptor potential p8

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_134252.5 → NP_599013.1  transient receptor potential cation channel subfamily M member 8

      See identical proteins and their annotated locations for NP_599013.1

      Status: VALIDATED

      Source sequence(s)
      AC087780, AC102505, FQ976922
      Consensus CDS
      CCDS48316.1
      UniProtKB/Swiss-Prot
      E9Q165, Q148W9, Q8R4D5
      Conserved Domains (2) summary
      TIGR00870
      Location:657 → 1005
      trp; transient-receptor-potential calcium channel protein
      cl39032
      Location:116 → 386
      LSDAT_euk; SLOG in TRPM

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000067.7 Reference GRCm39 C57BL/6J

      Range
      88234457..88318909
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006529226.2 → XP_006529289.1  transient receptor potential cation channel subfamily M member 8 isoform X1

      See identical proteins and their annotated locations for XP_006529289.1

      UniProtKB/Swiss-Prot
      E9Q165, Q148W9, Q8R4D5
      Related
      ENSMUSP00000036991.8, ENSMUST00000040210.14
      Conserved Domains (2) summary
      TIGR00870
      Location:657 → 1005
      trp; transient-receptor-potential calcium channel protein
      cl39032
      Location:116 → 386
      LSDAT_euk; SLOG in TRPM

    2. XM_017319118.2 → XP_017174607.1  transient receptor potential cation channel subfamily M member 8 isoform X2

      Conserved Domains (1) summary
      cl39032
      Location:116 → 386
      LSDAT_euk; SLOG in TRPM

    3. XM_006529225.2 → XP_006529288.1  transient receptor potential cation channel subfamily M member 8 isoform X1

      See identical proteins and their annotated locations for XP_006529288.1

      UniProtKB/Swiss-Prot
      E9Q165, Q148W9, Q8R4D5
      Related
      ENSMUSP00000131209.3, ENSMUST00000171176.3
      Conserved Domains (2) summary
      TIGR00870
      Location:657 → 1005
      trp; transient-receptor-potential calcium channel protein
      cl39032
      Location:116 → 386
      LSDAT_euk; SLOG in TRPM

    4. XM_006529229.1 → XP_006529292.1  transient receptor potential cation channel subfamily M member 8 isoform X3

      Conserved Domains (1) summary
      TIGR00870
      Location:148 → 496
      trp; transient-receptor-potential calcium channel protein
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8R4D5.3 GenPept UniProtKB/Swiss-Prot:Q8R4D5

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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