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    Fgfr1op2 FGFR1 oncogene partner 2 [ Mus musculus (house mouse) ]

    Gene ID: 67529, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Fgfr1op2provided by MGI
    Official Full Name
    FGFR1 oncogene partner 2provided by MGI
    Primary source
    MGI:MGI:1914779
    See related
    Ensembl:ENSMUSG00000040242 AllianceGenome:MGI:1914779
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    1500031J01Rik
    Summary
    Enables identical protein binding activity. Acts upstream of or within wound healing. Predicted to be located in cytoplasm. Is expressed in thymus primordium. Orthologous to human FGFR1OP2 (FGFR1 oncogene partner 2). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Ubiquitous expression in bladder adult (RPKM 25.4), testis adult (RPKM 22.4) and 28 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Fgfr1op2 in Genome Data Viewer
    Location:
    6 G3; 6 77.7 cM
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 6 NC_000072.7 (146479401..146500696)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 6 NC_000072.6 (146577903..146599198)

    Chromosome 6 - NC_000072.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 53316 Neighboring gene CapStarr-seq enhancer MGSCv37_chr6:146470563-146470746 Neighboring gene STARR-positive B cell enhancer ABC_E10421 Neighboring gene integrator complex subunit 13 Neighboring gene transmembrane 7 superfamily member 3 Neighboring gene STARR-positive B cell enhancer ABC_E1076 Neighboring gene mediator complex subunit 21 Neighboring gene predicted pseudogene 6654

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. FGFR1OP2-FGFR1 induced myeloid leukemia and T-cell lymphoma in a mouse model. Qin H, et al. Haematologica, 2016 Mar. PMID 26589915, Free PMC Article
    2. Small cytoskeleton-associated molecule, fibroblast growth factor receptor 1 oncogene partner 2/wound inducible transcript-3.0 (FGFR1OP2/wit3.0), facilitates fibroblast-driven wound closure. Lin A, et al. Am J Pathol, 2010 Jan. PMID 19959814, Free PMC Article
    3. Cartilage-specific ablation of site-1 protease in mice results in the endoplasmic reticulum entrapment of type IIb procollagen and down-regulation of cholesterol and lipid homeostasis. Patra D, et al. PLoS One, 2014. PMID 25147951, Free PMC Article
    4. Quantitative trait loci for body size components in mice. Kenney-Hunt JP, et al. Mamm Genome, 2006 Jun. PMID 16783635
    5. Neuron-specific protein network mapping of autism risk genes identifies shared biological mechanisms and disease-relevant pathologies. Murtaza N, et al. Cell Rep, 2022 Nov 22. PMID 36417873

    See all (26) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. FGFR1OP2-FGFR1 fusion in hematopoietic stem cells induced myeloid leukemia and T-cell lymphoma in a mouse model.
      Title: FGFR1OP2-FGFR1 induced myeloid leukemia and T-cell lymphoma in a mouse model.
    2. FGFR1OP2/wit3.0 may regulate cell motility and stimulate wound closure.
      Title: Small cytoskeleton-associated molecule, fibroblast growth factor receptor 1 oncogene partner 2/wound inducible transcript-3.0 (FGFR1OP2/wit3.0), facilitates fibroblast-driven wound closure.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (2) 

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables identical protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in response to wounding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within wound healing IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    FGFR1 oncogene partner 2 homolog

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001347513.1 → NP_001334442.1  FGFR1 oncogene partner 2 homolog isoform 2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) lacks an in-frame exon in the central coding region, compared to variant 1. The encoded isoform (2) is shorter than isoform 1.
      Source sequence(s)
      AK151318, AK169380, BF466380
      Consensus CDS
      CCDS85186.1
      UniProtKB/Swiss-Prot
      Q9CRA9
      Related
      ENSMUSP00000098352.4, ENSMUST00000067404.13
      Conserved Domains (1) summary
      pfam05769
      Location:2 → 183
      SIKE; SIKE family

    2. NM_026218.2 → NP_080494.1  FGFR1 oncogene partner 2 homolog isoform 1

      See identical proteins and their annotated locations for NP_080494.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) encodes the longer isoform (1).
      Source sequence(s)
      AK004662, AK005320, AK050102, AK159805
      Consensus CDS
      CCDS39711.1
      UniProtKB/Swiss-Prot
      Q3TEX1, Q3TW81, Q9CRA9, Q9D7R0
      Related
      ENSMUSP00000107292.3, ENSMUST00000111663.9
      Conserved Domains (1) summary
      pfam05769
      Location:2 → 221
      SIKE; SIKE family

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000072.7 Reference GRCm39 C57BL/6J

      Range
      146479401..146500696
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9CRA9.1 GenPept UniProtKB/Swiss-Prot:Q9CRA9

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Chemical Information
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