Cd27 CD27 antigen [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Cd27provided by MGI
Official Full Name: CD27 antigenprovided by MGI
Primary source: MGI:MGI:88326
See related: Ensembl:ENSMUSG00000030336 AllianceGenome:MGI:88326
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: S152; Tp55; Tnfrsf7
Summary: Enables transmembrane signaling receptor activity. Involved in CD27 signaling pathway; negative regulation of apoptotic process; and positive regulation of JNK cascade. Acts upstream of or within negative regulation of T cell apoptotic process. Located in external side of plasma membrane. Is active in plasma membrane. Is expressed in several structures, including femur; hemolymphoid system; intestine; pituitary gland; and reproductive system. Human ortholog(s) of this gene implicated in lymphoproliferative syndrome 2. Orthologous to human CD27 (CD27 molecule). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Biased expression in thymus adult (RPKM 190.8), spleen adult (RPKM 23.5) and 1 other tissue See more
Orthologs: human all
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Genomic context

Location:: 6 F3; 6 59.32 cM

Exon count:: 5

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	6	NC_000072.7 (125209583..125214014, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	6	NC_000072.6 (125232620..125237136, complement)

Chromosome 6 - NC_000072.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

The CD27/CD70 pathway negatively regulates visceral adipose tissue-resident Th2 cells and controls metabolic homeostasis.
Title: The CD27/CD70 pathway negatively regulates visceral adipose tissue-resident Th2 cells and controls metabolic homeostasis.
Nasopharyngeal carcinoma cells promote regulatory T cell development and suppressive activity via CD70-CD27 interaction.
Title: Nasopharyngeal carcinoma cells promote regulatory T cell development and suppressive activity via CD70-CD27 interaction.
Interleukin-6 receptor alpha and CD27 discriminate intratumoral T helper 17 subpopulations with distinct functional properties in a mouse lung cancer model.
Title: Interleukin-6 receptor alpha and CD27 discriminate intratumoral T helper 17 subpopulations with distinct functional properties in a mouse lung cancer model.
results demonstrate a previously unappreciated role of CD27 stimulation as a positive regulator of IL-7Ralpha during CD8 T-cell responses, provide insights into the mechanistic basis by which CD27 stimulation influences CD8(+) T-cell memory differentiation.
Title: Frontline Science: Late CD27 stimulation promotes IL-7Rα transcriptional re-expression and memory T cell qualities in effector CD8(+) T cells.
the results suggest that CD27 does not promote effector T cell survival by increasing expression of antiapoptotic BCL2 family members but instead acts by preferentially suppressing the cell-extrinsic apoptosis pathway, highlighting a previously unidentified role for CD27 in augmenting autoreactive effector T cell responses.
Title: CD27 Promotes CD4(+) Effector T Cell Survival in Response to Tissue Self-Antigen.
CD27 and GITR co-stimulate antigen-dependent T cell activation. PD-1 efficiently inhibits T cell activation even with CD27 co-stimulation.
Title: PD-1 efficiently inhibits T cell activation even in the presence of co-stimulation through CD27 and GITR.
The CD27 plays both redundant and distinct roles in regulating Regulatory T cells (Treg) plasticity in tissues.
Title: The TNFRSF members CD27 and OX40 coordinately limit T(H)17 differentiation in regulatory T cells.
CD27 expression is upregulated in a subset of hematopoietic cluster cells, and CD27 marks hematopoietic stem cells (HSC), type II pre-HSCs, and progenitors with lymphoid potential within the cluster cells.
Title: CD27 marks murine embryonic hematopoietic stem cells and type II prehematopoietic stem cells.
CD70 reverse signaling enhances NK cell function and immunosurveillance in CD27-expressing B-cell malignancies.
Title: CD70 reverse signaling enhances NK cell function and immunosurveillance in CD27-expressing B-cell malignancies.
CD27-dependent CD8(+) T cell priming and differentiation are shaped by the efficiency of NK responses to virus infection.
Title: Acute Virus Control Mediated by Licensed NK Cells Sets Primary CD8+ T Cell Dependence on CD27 Costimulation.

Submit: New GeneRIF Correction See all GeneRIFs (58)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (8)
Targeted (5) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

Tnfrsf7 (e-PCR), detects polymorphism
- UniSTS:144658

Tnfrsf7 (e-PCR), detects polymorphism
- UniSTS:144659

NoName (e-PCR)
- UniSTS:485009

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables cysteine-type endopeptidase inhibitor activity involved in apoptotic process	ISO Inferred from Sequence Orthology more info
enables cysteine-type endopeptidase inhibitor activity involved in apoptotic process	ISS Inferred from Sequence or Structural Similarity more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables transmembrane signaling receptor activity	IDA Inferred from Direct Assay more info	PubMed
enables transmembrane signaling receptor activity	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in B cell proliferation	NAS Non-traceable Author Statement more info	PubMed
involved_in CD27 signaling pathway	IDA Inferred from Direct Assay more info	PubMed
involved_in CD27 signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in T cell activation	IEA Inferred from Electronic Annotation more info
involved_in adaptive immune memory response involving T cells and B cells	ISO Inferred from Sequence Orthology more info
involved_in adaptive immune memory response involving T cells and B cells	ISS Inferred from Sequence or Structural Similarity more info
involved_in cell surface receptor signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in extrinsic apoptotic signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in extrinsic apoptotic signaling pathway	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within negative regulation of T cell apoptotic process	IPI Inferred from Physical Interaction more info	PubMed
involved_in negative regulation of apoptotic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in negative regulation of apoptotic process	IDA Inferred from Direct Assay more info	PubMed
involved_in negative regulation of apoptotic process	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of apoptotic process	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of B cell differentiation	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of JNK cascade	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of T cell differentiation	NAS Non-traceable Author Statement more info	PubMed
involved_in positive regulation of immunoglobulin production	NAS Non-traceable Author Statement more info	PubMed
involved_in positive regulation of type II interferon production	NAS Non-traceable Author Statement more info	PubMed

Component	Evidence Code	Pubs
located_in cell surface	IDA Inferred from Direct Assay more info	PubMed
is_active_in external side of plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in external side of plasma membrane	IDA Inferred from Direct Assay more info	PubMed
is_active_in plasma membrane	IDA Inferred from Direct Assay more info	PubMed
is_active_in plasma membrane	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: CD27 antigen

Names: CD antigen 27; CD27L receptor; T-cell activation antigen CD27; tumor necrosis factor receptor superfamily member 7

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001033126.2 → NP_001028298.1 CD27 antigen isoform a precursor

Status: VALIDATED

Description

Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (a).

Source sequence(s)

AA475779, AC140324, AI326735, DT924276

Consensus CDS

CCDS39639.1

UniProtKB/Swiss-Prot

P41272

UniProtKB/TrEMBL

Q3U4X0

Related

ENSMUSP00000032486.7, ENSMUST00000032486.13

Conserved Domains (1) summary

cd13408
Location:4 → 123

TNFRSF7; Tumor necrosis factor receptor superfamily member 7 (TNFRSF7), also known as CD27
NM_001042564.1 → NP_001036029.1 CD27 antigen isoform b precursor

Status: VALIDATED

Description

Transcript Variant: This variant (2) lacks two alternate in-frame exons in the 5' coding region, compared to variant 1. It encodes isoform b, which is shorter than isoform a.

Source sequence(s)

AC140324, AI326735, BE631582

Consensus CDS

CCDS39638.1

UniProtKB/TrEMBL

B7ZW87

Related

ENSMUSP00000107901.3, ENSMUST00000112282.3

Conserved Domains (1) summary

cl22855
Location:4 → 45

TNFRSF; Tumor necrosis factor receptor superfamily (TNFRSF)
NM_001286753.1 → NP_001273682.1 CD27 antigen isoform c precursor

Status: VALIDATED

Description

Transcript Variant: This variant (3) lacks an alternate in-frame exon in the 5' coding region, compared to variant 1. It encodes isoform c, which is shorter than isoform a.

Source sequence(s)

AC140324, AI326735, DT924276

Consensus CDS

CCDS71839.1

UniProtKB/TrEMBL

D3Z7W5

Related

ENSMUSP00000107900.2, ENSMUST00000112281.8

Conserved Domains (1) summary

cl22855
Location:4 → 89

TNFRSF; Tumor necrosis factor receptor superfamily (TNFRSF)

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000072.7 Reference GRCm39 C57BL/6J

Range

125209583..125214014 complement

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_006505901.5 → XP_006505964.1 CD27 antigen isoform X4

Conserved Domains (1) summary

cl22855
Location:4 → 45

TNFRSF; Tumor necrosis factor receptor superfamily (TNFRSF)
XM_006505900.5 → XP_006505963.1 CD27 antigen isoform X3

Conserved Domains (2) summary

cd00185
Location:10 → 62

TNFRSF; CRD1 [structural motif]

cl22855
Location:4 → 89

TNFRSF; Tumor necrosis factor receptor superfamily (TNFRSF)
XM_011241288.3 → XP_011239590.1 CD27 antigen isoform X2

Conserved Domains (2) summary

cd00185
Location:62 → 77

TNFRSF; CRD3 [structural motif]

cl22855
Location:4 → 79

TNFRSF; Tumor necrosis factor receptor superfamily (TNFRSF)
XM_006505898.5 → XP_006505961.1 CD27 antigen isoform X1

Conserved Domains (1) summary

cd13408
Location:4 → 123

TNFRSF7; Tumor necrosis factor receptor superfamily member 7 (TNFRSF7), also known as CD27