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    Copg1 coatomer protein complex, subunit gamma 1 [ Mus musculus (house mouse) ]

    Gene ID: 54161, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Copg1provided by MGI
    Official Full Name
    coatomer protein complex, subunit gamma 1provided by MGI
    Primary source
    MGI:MGI:1858696
    See related
    Ensembl:ENSMUSG00000030058 AllianceGenome:MGI:1858696
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Copg; D6Wsu16e; D6Ertd71e
    Summary
    Predicted to enable structural molecule activity. Predicted to be involved in several processes, including Golgi vesicle transport; establishment of Golgi localization; and organelle transport along microtubule. Located in Golgi membrane. Is expressed in several structures, including alimentary system; genitourinary system; heart; nervous system; and sensory organ. Used to study combined immunodeficiency and polyclonal hypergammaglobulinemia. Orthologous to human COPG1 (COPI coat complex subunit gamma 1). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Ubiquitous expression in cerebellum adult (RPKM 31.9), limb E14.5 (RPKM 28.3) and 28 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Copg1 in Genome Data Viewer
    Location:
    6 D1; 6 39.13 cM
    Exon count:
    24
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 6 NC_000072.7 (87864801..87890577)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 6 NC_000072.6 (87887819..87913595)

    Chromosome 6 - NC_000072.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_16567 Neighboring gene ISY1 splicing factor homolog Neighboring gene cellular nucleic acid binding protein Neighboring gene STARR-seq mESC enhancer starr_16568 Neighboring gene STARR-positive B cell enhancer ABC_E2793 Neighboring gene STARR-positive B cell enhancer ABC_E1704 Neighboring gene 5-hydroxymethylcytosine (hmC) binding, ES cell specific Neighboring gene eukaryotic translation elongation factor 1 alpha 1 pseudogene Neighboring gene ribosomal protein S19, pseudogene 9

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Combined immunodeficiency due to a mutation in the γ1 subunit of the coat protein I complex. Bainter W, et al. J Clin Invest, 2021 Feb 1. PMID 33529166, Free PMC Article
    2. mTrs130 is a component of a mammalian TRAPPII complex, a Rab1 GEF that binds to COPI-coated vesicles. Yamasaki A, et al. Mol Biol Cell, 2009 Oct. PMID 19656848, Free PMC Article
    3. Differential localization of coatomer complex isoforms within the Golgi apparatus. Moelleken J, et al. Proc Natl Acad Sci U S A, 2007 Mar 13. PMID 17360540
    4. Duplication of genes encoding non-clathrin coat protein gamma-COP in vertebrate, insect and plant evolution. Hahn Y, et al. FEBS Lett, 2000 Sep 29. PMID 11018518
    5. Mit1/Lb9 and Copg2, new members of mouse imprinted genes closely linked to Peg1/Mest(1). Lee YJ, et al. FEBS Lett, 2000 Apr 28. PMID 10788617

    See all (40) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Combined immunodeficiency due to a mutation in the gamma1 subunit of the coat protein I complex.
      Title: Combined immunodeficiency due to a mutation in the γ1 subunit of the coat protein I complex.
    2. Data show Trs130 (mTrs130) is a component of an analogous TRAPP complex that this complex is enriched on COPI (Coat Protein I)-coated vesicles it specifically activates Rab1.
      Title: mTrs130 is a component of a mammalian TRAPPII complex, a Rab1 GEF that binds to COPI-coated vesicles.
    3. analysis of differential localization of coatomer complex isoforms within the Golgi apparatus
      Title: Differential localization of coatomer complex isoforms within the Golgi apparatus.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (2)  1 citation
    • Targeted (1) 

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC66965

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables structural molecule activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in endoplasmic reticulum to Golgi vesicle-mediated transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in establishment of Golgi localization ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in intra-Golgi vesicle-mediated transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in intracellular protein transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in organelle transport along microtubule IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in organelle transport along microtubule ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in protein secretion IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in vesicle-mediated transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    part_of COPI vesicle coat IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of COPI vesicle coat IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in Golgi apparatus ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in Golgi membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in Golgi membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in Golgi membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cytosol IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in endoplasmic reticulum IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in endoplasmic reticulum-Golgi intermediate compartment IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    coatomer subunit gamma-1
    Names
    coatomer subunit gamma
    gamma-1-COP
    gamma-1-coat protein
    gamma-COP
    gamma-coat protein

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_017477.2 → NP_059505.1  coatomer subunit gamma-1 isoform 1

      See identical proteins and their annotated locations for NP_059505.1

      Status: PROVISIONAL

      Source sequence(s)
      AC153872
      Consensus CDS
      CCDS39549.1
      UniProtKB/Swiss-Prot
      Q3U9F4, Q8BP96, Q8R1A7, Q922C6, Q9QZE5
      Related
      ENSMUSP00000109237.4, ENSMUST00000113607.10
      Conserved Domains (2) summary
      COG5240
      Location:7 → 869
      SEC21; Vesicle coat complex COPI, gamma subunit [Intracellular trafficking and secretion]
      sd00044
      Location:398 → 423
      HEAT; HEAT repeat [structural motif]

    2. NM_201244.1 → NP_957696.1  coatomer subunit gamma-1 isoform 2

      See identical proteins and their annotated locations for NP_957696.1

      Status: PROVISIONAL

      Source sequence(s)
      BC056168
      Consensus CDS
      CCDS39550.1
      UniProtKB/TrEMBL
      Q7TNQ1
      Related
      ENSMUSP00000050858.6, ENSMUST00000049966.6
      Conserved Domains (1) summary
      COG5240
      Location:7 → 107
      SEC21; Vesicle coat complex COPI, gamma subunit [Intracellular trafficking and secretion]

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000072.7 Reference GRCm39 C57BL/6J

      Range
      87864801..87890577
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    RNA

    1. XR_001785155.1 RNA Sequence

    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9QZE5.1 GenPept UniProtKB/Swiss-Prot:Q9QZE5

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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