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    Lrrfip2 leucine rich repeat (in FLII) interacting protein 2 [ Mus musculus (house mouse) ]

    Gene ID: 71268, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Lrrfip2provided by MGI
    Official Full Name
    leucine rich repeat (in FLII) interacting protein 2provided by MGI
    Primary source
    MGI:MGI:1918518
    See related
    Ensembl:ENSMUSG00000032497 AllianceGenome:MGI:1918518
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    5133400F20Rik
    Summary
    Predicted to enable LRR domain binding activity. Acts upstream of or within regulation of gene expression and toll-like receptor signaling pathway. Is expressed in 1st branchial arch mandibular component mesenchyme; craniocervical region bone; and facial prominence. Orthologous to human LRRFIP2 (LRR binding FLII interacting protein 2). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Ubiquitous expression in testis adult (RPKM 12.8), placenta adult (RPKM 9.9) and 28 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Lrrfip2 in Genome Data Viewer
    Location:
    9 F3; 9 60.92 cM
    Exon count:
    33
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 9 NC_000075.7 (110946614..111054736)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 9 NC_000075.6 (111117546..111225668)

    Chromosome 9 - NC_000075.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_25286 Neighboring gene ribosomal protein L31, pseudogene 19 Neighboring gene predicted gene, 26409 Neighboring gene predicted gene, 53519 Neighboring gene STARR-seq mESC enhancer starr_25288 Neighboring gene predicted gene, 57536 Neighboring gene predicted gene, 51692 Neighboring gene mutL homolog 1 Neighboring gene CapStarr-seq enhancer MGSCv37_chr9:111177746-111177899 Neighboring gene EPM2A interacting protein 1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Unambiguous characterization of site-specific phosphorylation of leucine-rich repeat Fli-I-interacting protein 2 (LRRFIP2) in Toll-like receptor 4 (TLR4)-mediated signaling. Gunawardena HP, et al. J Biol Chem, 2011 Apr 1. PMID 21220426, Free PMC Article
    2. LRRFIP2 negatively regulates NLRP3 inflammasome activation in macrophages by promoting Flightless-I-mediated caspase-1 inhibition. Jin J, et al. Nat Commun, 2013. PMID 23942110, Free PMC Article
    3. Modulation of TLR signaling by multiple MyD88-interacting partners including leucine-rich repeat Fli-I-interacting proteins. Dai P, et al. J Immunol, 2009 Mar 15. PMID 19265123
    4. In vivo dual-tagging proteomic approach in studying signaling pathways in immune response. Wang T, et al. J Proteome Res, 2005 May-Jun. PMID 15952741
    5. An Alternative Splicing Program for Mouse Craniofacial Development. Hooper JE, et al. Front Physiol, 2020. PMID 33013468, Free PMC Article

    See all (33) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. LRRFIP2 inhibits NLRP3 inflammasome activation by recruiting the caspase-1 inhibitor Flightless-I, thus outlining a new mechanism for negative regulation of NLRP3 inflammasome.
      Title: LRRFIP2 negatively regulates NLRP3 inflammasome activation in macrophages by promoting Flightless-I-mediated caspase-1 inhibition.
    2. Unambiguous characterization of site-specific phosphorylation of leucine-rich repeat Fli-I-interacting protein 2 (LRRFIP2) in Toll-like receptor 4 (TLR4)-mediated signaling.
      Title: Unambiguous characterization of site-specific phosphorylation of leucine-rich repeat Fli-I-interacting protein 2 (LRRFIP2) in Toll-like receptor 4 (TLR4)-mediated signaling.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables LRR domain binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    acts_upstream_of_or_within MyD88-dependent toll-like receptor 4 signaling pathway IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    acts_upstream_of_or_within MyD88-independent toll-like receptor signaling pathway IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in Wnt signaling pathway IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within positive regulation of NF-kappaB transcription factor activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    acts_upstream_of_or_within positive regulation of NF-kappaB transcription factor activity IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    acts_upstream_of_or_within positive regulation of NF-kappaB transcription factor activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within positive regulation of tumor necrosis factor production IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in regulation of DNA-templated transcription IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    leucine-rich repeat flightless-interacting protein 2
    Names
    LRR FLII-interacting protein 2

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001164838.1 → NP_001158310.1  leucine-rich repeat flightless-interacting protein 2 isoform 1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) encodes isoform 1.
      Source sequence(s)
      AC132832, AK078881, BY346593
      Consensus CDS
      CCDS52941.1
      UniProtKB/Swiss-Prot
      Q8BVD1, Q91WK0, Q9CU89
      UniProtKB/TrEMBL
      E9QN52
      Related
      ENSMUSP00000035078.7, ENSMUST00000035078.13
      Conserved Domains (2) summary
      pfam04111
      Location:311 → 405
      APG6; Autophagy protein Apg6
      pfam09738
      Location:47 → 340
      LRRFIP; LRRFIP family

    2. NM_001374664.1 → NP_001361593.1  leucine-rich repeat flightless-interacting protein 2 isoform 3

      Status: VALIDATED

      Source sequence(s)
      AC132832
      Consensus CDS
      CCDS90673.1
      UniProtKB/Swiss-Prot
      Q8BVD1, Q91WK0, Q9CU89
      UniProtKB/TrEMBL
      A0A0G2JEP4
      Related
      ENSMUSP00000142851.2, ENSMUST00000196981.5
      Conserved Domains (2) summary
      pfam09738
      Location:47 → 349
      LRRFIP; LRRFIP family
      pfam11932
      Location:365 → 424
      DUF3450; Protein of unknown function (DUF3450)

    3. NM_027742.3 → NP_082018.1  leucine-rich repeat flightless-interacting protein 2 isoform 2

      See identical proteins and their annotated locations for NP_082018.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) lacks an exon in the 5' coding region compared to variant 1 but maintains the reading frame. The resulting protein (isoform 2) is shorter than isoform 1.
      Source sequence(s)
      AC132832, AK078881, BY346593
      Consensus CDS
      CCDS23583.1
      UniProtKB/Swiss-Prot
      Q8BVD1, Q91WK0, Q9CU89
      UniProtKB/TrEMBL
      A0A0R4J169
      Related
      ENSMUSP00000095944.3, ENSMUST00000098340.7
      Conserved Domains (2) summary
      pfam04111
      Location:296 → 390
      APG6; Autophagy protein Apg6
      pfam09738
      Location:47 → 325
      LRRFIP; LRRFIP family

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000075.7 Reference GRCm39 C57BL/6J

      Range
      110946614..111054736
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_011243000.3 → XP_011241302.1  leucine-rich repeat flightless-interacting protein 2 isoform X1

      UniProtKB/TrEMBL
      A0A668KLE1
      Conserved Domains (3) summary
      TIGR04211
      Location:465 → 549
      SH3_and_anchor; SH3 domain protein
      pfam09738
      Location:319 → 673
      LRRFIP; LRRFIP family
      pfam11932
      Location:689 → 748
      DUF3450; Protein of unknown function (DUF3450)

    2. XM_036155284.1 → XP_036011177.1  leucine-rich repeat flightless-interacting protein 2 isoform X7

      UniProtKB/TrEMBL
      A0A668KLE1
      Conserved Domains (2) summary
      pfam09738
      Location:319 → 642
      LRRFIP; LRRFIP family
      pfam11932
      Location:658 → 717
      DUF3450; Protein of unknown function (DUF3450)

    3. XM_017313589.3 → XP_017169078.1  leucine-rich repeat flightless-interacting protein 2 isoform X15

      UniProtKB/TrEMBL
      A0A668KLE1
      Conserved Domains (2) summary
      pfam09738
      Location:319 → 608
      LRRFIP; LRRFIP family
      pfam11932
      Location:624 → 683
      DUF3450; Protein of unknown function (DUF3450)

    4. XM_011243004.3 → XP_011241306.1  leucine-rich repeat flightless-interacting protein 2 isoform X5

      UniProtKB/TrEMBL
      A0A668KLE1
      Conserved Domains (3) summary
      TIGR04211
      Location:441 → 525
      SH3_and_anchor; SH3 domain protein
      pfam09738
      Location:319 → 649
      LRRFIP; LRRFIP family
      pfam11932
      Location:665 → 724
      DUF3450; Protein of unknown function (DUF3450)

    5. XM_017313590.3 → XP_017169079.1  leucine-rich repeat flightless-interacting protein 2 isoform X17

      UniProtKB/TrEMBL
      A0A668KLE1
      Conserved Domains (2) summary
      pfam09738
      Location:319 → 584
      LRRFIP; LRRFIP family
      pfam11932
      Location:600 → 659
      DUF3450; Protein of unknown function (DUF3450)

    6. XM_036155286.1 → XP_036011179.1  leucine-rich repeat flightless-interacting protein 2 isoform X14

      UniProtKB/TrEMBL
      A0A668KLE1
      Conserved Domains (2) summary
      pfam09738
      Location:286 → 609
      LRRFIP; LRRFIP family
      pfam11932
      Location:625 → 684
      DUF3450; Protein of unknown function (DUF3450)

    7. XM_030244586.1 → XP_030100446.1  leucine-rich repeat flightless-interacting protein 2 isoform X16

      UniProtKB/TrEMBL
      A0A668KLE1
      Conserved Domains (2) summary
      pfam09738
      Location:301 → 600
      LRRFIP; LRRFIP family
      pfam11932
      Location:616 → 675
      DUF3450; Protein of unknown function (DUF3450)

    8. XM_036155287.1 → XP_036011180.1  leucine-rich repeat flightless-interacting protein 2 isoform X22

      Conserved Domains (2) summary
      pfam09738
      Location:196 → 485
      LRRFIP; LRRFIP family
      pfam11932
      Location:501 → 560
      DUF3450; Protein of unknown function (DUF3450)

    9. XM_030244588.2 → XP_030100448.1  leucine-rich repeat flightless-interacting protein 2 isoform X24

      UniProtKB/TrEMBL
      A0A0G2JFV5
      Conserved Domains (2) summary
      pfam09738
      Location:196 → 461
      LRRFIP; LRRFIP family
      pfam11932
      Location:477 → 536
      DUF3450; Protein of unknown function (DUF3450)

    10. XM_030244589.1 → XP_030100449.1  leucine-rich repeat flightless-interacting protein 2 isoform X26

      Conserved Domains (2) summary
      pfam09738
      Location:47 → 435
      LRRFIP; LRRFIP family
      pfam11932
      Location:451 → 510
      DUF3450; Protein of unknown function (DUF3450)

    11. XM_030244591.1 → XP_030100451.1  leucine-rich repeat flightless-interacting protein 2 isoform X31

      Conserved Domains (2) summary
      pfam09738
      Location:47 → 411
      LRRFIP; LRRFIP family
      pfam11932
      Location:427 → 486
      DUF3450; Protein of unknown function (DUF3450)

    12. XM_011243024.3 → XP_011241326.1  leucine-rich repeat flightless-interacting protein 2 isoform X32

      Conserved Domains (3) summary
      TIGR04211
      Location:197 → 281
      SH3_and_anchor; SH3 domain protein
      pfam05266
      Location:380 → 454
      DUF724; Protein of unknown function (DUF724)
      pfam09738
      Location:47 → 405
      LRRFIP; LRRFIP family

    13. XM_011243026.3 → XP_011241328.1  leucine-rich repeat flightless-interacting protein 2 isoform X43

      UniProtKB/TrEMBL
      A0A1L1SSC0
      Conserved Domains (2) summary
      pfam09738
      Location:267 → 532
      LRRFIP; LRRFIP family
      pfam11932
      Location:548 → 607
      DUF3450; Protein of unknown function (DUF3450)

    14. XM_030244587.2 → XP_030100447.1  leucine-rich repeat flightless-interacting protein 2 isoform X20

      UniProtKB/TrEMBL
      A0A1L1SSC0
      Conserved Domains (2) summary
      pfam09738
      Location:200 → 489
      LRRFIP; LRRFIP family
      pfam11932
      Location:505 → 564
      DUF3450; Protein of unknown function (DUF3450)

    15. XM_036155288.1 → XP_036011181.1  leucine-rich repeat flightless-interacting protein 2 isoform X35

      Conserved Domains (2) summary
      pfam09738
      Location:47 → 380
      LRRFIP; LRRFIP family
      pfam11932
      Location:396 → 455
      DUF3450; Protein of unknown function (DUF3450)

    16. XM_017313591.3 → XP_017169080.1  leucine-rich repeat flightless-interacting protein 2 isoform X34

      Conserved Domains (2) summary
      pfam05266
      Location:358 → 432
      DUF724; Protein of unknown function (DUF724)
      pfam09738
      Location:47 → 383
      LRRFIP; LRRFIP family

    17. XM_030244593.1 → XP_030100453.1  leucine-rich repeat flightless-interacting protein 2 isoform X33

      Conserved Domains (3) summary
      TIGR04211
      Location:182 → 266
      SH3_and_anchor; SH3 domain protein
      pfam05266
      Location:365 → 439
      DUF724; Protein of unknown function (DUF724)
      pfam09738
      Location:47 → 390
      LRRFIP; LRRFIP family

    18. XM_036155289.1 → XP_036011182.1  leucine-rich repeat flightless-interacting protein 2 isoform X39

      Conserved Domains (2) summary
      pfam09738
      Location:47 → 356
      LRRFIP; LRRFIP family
      pfam11932
      Location:372 → 431
      DUF3450; Protein of unknown function (DUF3450)

    19. XM_030244596.1 → XP_030100456.1  leucine-rich repeat flightless-interacting protein 2 isoform X38

      Conserved Domains (2) summary
      pfam09738
      Location:47 → 359
      LRRFIP; LRRFIP family
      pfam11932
      Location:375 → 434
      DUF3450; Protein of unknown function (DUF3450)

    20. XM_011243001.4 → XP_011241303.1  leucine-rich repeat flightless-interacting protein 2 isoform X2

      UniProtKB/TrEMBL
      A0A668KLE1
      Related
      ENSMUSP00000159250.2, ENSMUST00000239186.2
      Conserved Domains (3) summary
      TIGR04211
      Location:462 → 546
      SH3_and_anchor; SH3 domain protein
      pfam09738
      Location:316 → 670
      LRRFIP; LRRFIP family
      pfam11932
      Location:686 → 745
      DUF3450; Protein of unknown function (DUF3450)

    21. XM_036155285.1 → XP_036011178.1  leucine-rich repeat flightless-interacting protein 2 isoform X9

      UniProtKB/TrEMBL
      A0A668KLE1
      Conserved Domains (2) summary
      pfam09738
      Location:286 → 640
      LRRFIP; LRRFIP family
      pfam11932
      Location:656 → 715
      DUF3450; Protein of unknown function (DUF3450)

    22. XM_011243005.4 → XP_011241307.1  leucine-rich repeat flightless-interacting protein 2 isoform X6

      UniProtKB/TrEMBL
      A0A668KLE1
      Conserved Domains (3) summary
      TIGR04211
      Location:439 → 523
      SH3_and_anchor; SH3 domain protein
      pfam09738
      Location:293 → 647
      LRRFIP; LRRFIP family
      pfam11932
      Location:663 → 722
      DUF3450; Protein of unknown function (DUF3450)

    23. XM_011243012.4 → XP_011241314.1  leucine-rich repeat flightless-interacting protein 2 isoform X13

      UniProtKB/TrEMBL
      A0A668KLE1
      Conserved Domains (3) summary
      TIGR04211
      Location:409 → 493
      SH3_and_anchor; SH3 domain protein
      pfam09738
      Location:263 → 617
      LRRFIP; LRRFIP family
      pfam11932
      Location:633 → 692
      DUF3450; Protein of unknown function (DUF3450)

    24. XM_011243003.4 → XP_011241305.1  leucine-rich repeat flightless-interacting protein 2 isoform X4

      UniProtKB/TrEMBL
      A0A668KLE1
      Conserved Domains (3) summary
      TIGR04211
      Location:446 → 530
      SH3_and_anchor; SH3 domain protein
      pfam09738
      Location:300 → 654
      LRRFIP; LRRFIP family
      pfam11932
      Location:670 → 729
      DUF3450; Protein of unknown function (DUF3450)

    25. XM_011243002.4 → XP_011241304.1  leucine-rich repeat flightless-interacting protein 2 isoform X3

      UniProtKB/TrEMBL
      A0A668KLE1
      Conserved Domains (3) summary
      TIGR04211
      Location:450 → 534
      SH3_and_anchor; SH3 domain protein
      pfam09738
      Location:304 → 658
      LRRFIP; LRRFIP family
      pfam11932
      Location:674 → 733
      DUF3450; Protein of unknown function (DUF3450)

    26. XM_011243008.4 → XP_011241310.1  leucine-rich repeat flightless-interacting protein 2 isoform X10

      UniProtKB/TrEMBL
      A0A668KLE1
      Conserved Domains (3) summary
      TIGR04211
      Location:431 → 515
      SH3_and_anchor; SH3 domain protein
      pfam09738
      Location:285 → 639
      LRRFIP; LRRFIP family
      pfam11932
      Location:655 → 714
      DUF3450; Protein of unknown function (DUF3450)

    27. XM_011243007.4 → XP_011241309.1  leucine-rich repeat flightless-interacting protein 2 isoform X8

      UniProtKB/TrEMBL
      A0A668KLE1
      Conserved Domains (3) summary
      TIGR04211
      Location:433 → 517
      SH3_and_anchor; SH3 domain protein
      pfam09738
      Location:287 → 641
      LRRFIP; LRRFIP family
      pfam11932
      Location:657 → 716
      DUF3450; Protein of unknown function (DUF3450)

    28. XM_011243016.4 → XP_011241318.1  leucine-rich repeat flightless-interacting protein 2 isoform X18

      UniProtKB/TrEMBL
      A0A668KLE1
      Conserved Domains (3) summary
      TIGR04211
      Location:342 → 426
      SH3_and_anchor; SH3 domain protein
      pfam09738
      Location:196 → 550
      LRRFIP; LRRFIP family
      pfam11932
      Location:566 → 625
      DUF3450; Protein of unknown function (DUF3450)

    29. XM_011243017.4 → XP_011241319.1  leucine-rich repeat flightless-interacting protein 2 isoform X19

      UniProtKB/TrEMBL
      A0A668KLE1
      Conserved Domains (3) summary
      TIGR04211
      Location:337 → 421
      SH3_and_anchor; SH3 domain protein
      pfam09738
      Location:191 → 545
      LRRFIP; LRRFIP family
      pfam11932
      Location:561 → 620
      DUF3450; Protein of unknown function (DUF3450)

    30. XM_011243018.4 → XP_011241320.1  leucine-rich repeat flightless-interacting protein 2 isoform X21

      UniProtKB/TrEMBL
      A0A1L1SSC0
      Conserved Domains (3) summary
      TIGR04211
      Location:281 → 365
      SH3_and_anchor; SH3 domain protein
      pfam09738
      Location:135 → 489
      LRRFIP; LRRFIP family
      pfam11932
      Location:505 → 564
      DUF3450; Protein of unknown function (DUF3450)

    31. XM_011243019.4 → XP_011241321.1  leucine-rich repeat flightless-interacting protein 2 isoform X23

      UniProtKB/TrEMBL
      A0A1L1SSC0
      Conserved Domains (3) summary
      TIGR04211
      Location:258 → 342
      SH3_and_anchor; SH3 domain protein
      pfam09738
      Location:47 → 466
      LRRFIP; LRRFIP family
      pfam11932
      Location:482 → 541
      DUF3450; Protein of unknown function (DUF3450)

    32. XM_011243010.4 → XP_011241312.1  leucine-rich repeat flightless-interacting protein 2 isoform X11

      UniProtKB/TrEMBL
      A0A1L1SSC0
      Conserved Domains (3) summary
      TIGR04211
      Location:428 → 512
      SH3_and_anchor; SH3 domain protein
      pfam09738
      Location:282 → 636
      LRRFIP; LRRFIP family
      pfam11932
      Location:652 → 711
      DUF3450; Protein of unknown function (DUF3450)

    33. XM_011243021.4 → XP_011241323.1  leucine-rich repeat flightless-interacting protein 2 isoform X27

      Conserved Domains (3) summary
      TIGR04211
      Location:221 → 305
      SH3_and_anchor; SH3 domain protein
      pfam05266
      Location:404 → 478
      DUF724; Protein of unknown function (DUF724)
      pfam09738
      Location:47 → 429
      LRRFIP; LRRFIP family

    34. XM_011243011.4 → XP_011241313.1  leucine-rich repeat flightless-interacting protein 2 isoform X12

      UniProtKB/TrEMBL
      A0A1L1SSC0
      Related
      ENSMUSP00000149845.3, ENSMUST00000217341.3
      Conserved Domains (3) summary
      TIGR04211
      Location:413 → 497
      SH3_and_anchor; SH3 domain protein
      pfam09738
      Location:267 → 621
      LRRFIP; LRRFIP family
      pfam11932
      Location:637 → 696
      DUF3450; Protein of unknown function (DUF3450)

    35. XM_011243020.4 → XP_011241322.1  leucine-rich repeat flightless-interacting protein 2 isoform X25

      Conserved Domains (3) summary
      TIGR04211
      Location:229 → 313
      SH3_and_anchor; SH3 domain protein
      pfam05266
      Location:412 → 486
      DUF724; Protein of unknown function (DUF724)
      pfam09738
      Location:47 → 437
      LRRFIP; LRRFIP family

    36. XM_011243023.4 → XP_011241325.1  leucine-rich repeat flightless-interacting protein 2 isoform X30

      Conserved Domains (3) summary
      TIGR04211
      Location:206 → 290
      SH3_and_anchor; SH3 domain protein
      pfam05266
      Location:389 → 463
      DUF724; Protein of unknown function (DUF724)
      pfam09738
      Location:47 → 414
      LRRFIP; LRRFIP family

    37. XM_011243022.4 → XP_011241324.1  leucine-rich repeat flightless-interacting protein 2 isoform X28

      Conserved Domains (1) summary
      pfam09738
      Location:319 → 484
      LRRFIP; LRRFIP family

    38. XM_006512287.4 → XP_006512350.1  leucine-rich repeat flightless-interacting protein 2 isoform X29

      Conserved Domains (3) summary
      TIGR04211
      Location:212 → 296
      SH3_and_anchor; SH3 domain protein
      pfam05266
      Location:395 → 469
      DUF724; Protein of unknown function (DUF724)
      pfam09738
      Location:66 → 420
      LRRFIP; LRRFIP family

    39. XM_030244598.2 → XP_030100458.1  leucine-rich repeat flightless-interacting protein 2 isoform X41

      UniProtKB/TrEMBL
      A0A1L1SQW1
      Related
      ENSMUSP00000149212.2, ENSMUST00000216430.2
      Conserved Domains (2) summary
      pfam09738
      Location:36 → 301
      LRRFIP; LRRFIP family
      pfam11932
      Location:317 → 376
      DUF3450; Protein of unknown function (DUF3450)

    40. XM_030244595.2 → XP_030100455.1  leucine-rich repeat flightless-interacting protein 2 isoform X37

      UniProtKB/TrEMBL
      Q8C062
      Related
      ENSMUST00000197540.5
      Conserved Domains (3) summary
      TIGR04211
      Location:155 → 239
      SH3_and_anchor; SH3 domain protein
      pfam05266
      Location:338 → 412
      DUF724; Protein of unknown function (DUF724)
      pfam09738
      Location:33 → 363
      LRRFIP; LRRFIP family

    41. XM_030244599.2 → XP_030100459.1  leucine-rich repeat flightless-interacting protein 2 isoform X42

      UniProtKB/TrEMBL
      A0A1L1SQW1, A0A1L1SVG1
      Related
      ENSMUSP00000151145.2, ENSMUST00000217117.2
      Conserved Domains (2) summary
      pfam09738
      Location:33 → 298
      LRRFIP; LRRFIP family
      pfam11932
      Location:314 → 373
      DUF3450; Protein of unknown function (DUF3450)

    42. XM_030244597.1 → XP_030100457.1  leucine-rich repeat flightless-interacting protein 2 isoform X40

      UniProtKB/TrEMBL
      Q8C062
      Conserved Domains (2) summary
      pfam09738
      Location:13 → 309
      LRRFIP; LRRFIP family
      pfam11932
      Location:325 → 384
      DUF3450; Protein of unknown function (DUF3450)

    43. XM_006512290.2 → XP_006512353.1  leucine-rich repeat flightless-interacting protein 2 isoform X36

      UniProtKB/TrEMBL
      Q8C062
      Conserved Domains (3) summary
      TIGR04211
      Location:159 → 243
      SH3_and_anchor; SH3 domain protein
      pfam05266
      Location:342 → 416
      DUF724; Protein of unknown function (DUF724)
      pfam09738
      Location:13 → 367
      LRRFIP; LRRFIP family
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q91WK0.1 GenPept UniProtKB/Swiss-Prot:Q91WK0

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