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    Zfp26 zinc finger protein 26 [ Mus musculus (house mouse) ]

    Gene ID: 22688, updated on 4-Jan-2025

    Summary

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    Official Symbol
    Zfp26provided by MGI
    Official Full Name
    zinc finger protein 26provided by MGI
    Primary source
    MGI:MGI:99173
    See related
    Ensembl:ENSMUSG00000063108 AllianceGenome:MGI:99173
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Zfp70; mkr-3; KRAB15; Zfp-26; mszf14; mszf52; Zfp81-rs1; mKIAA4196; 5033428C05Rik
    Summary
    Predicted to enable DNA-binding transcription activator activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in regulation of transcription by RNA polymerase II. Predicted to be active in nucleus. Is expressed in several structures, including central nervous system; gonad; liver; lung; and spleen. Orthologous to several human genes including ZNF544 (zinc finger protein 544). [provided by Alliance of Genome Resources, Jan 2025]
    Expression
    Broad expression in CNS E11.5 (RPKM 4.4), whole brain E14.5 (RPKM 4.2) and 23 other tissues See more
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    Genomic context

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    See Zfp26 in Genome Data Viewer
    Location:
    9 A3; 9 7.55 cM
    Exon count:
    11
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 9 NC_000075.7 (20338457..20371465, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 9 NC_000075.6 (20428318..20460169, complement)

    Chromosome 9 - NC_000075.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_23456 Neighboring gene olfactory receptor family 7 subfamily E member 178 Neighboring gene zinc finger protein 560 Neighboring gene STARR-positive B cell enhancer ABC_E9752 Neighboring gene STARR-positive B cell enhancer ABC_E9753 Neighboring gene zinc finger protein 426 Neighboring gene predicted gene, 23316 Neighboring gene zinc finger protein 266

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Specific and ubiquitous expression of different Zn finger protein genes in the mouse. Chowdhury K, et al. Nucleic Acids Res, 1988 Nov 11. PMID 3143103, Free PMC Article
    2. Activation of the c-H-ras proto-oncogene by retrovirus insertion and chromosomal rearrangement in a Moloney leukemia virus-induced T-cell leukemia. Ihle JN, et al. J Virol, 1989 Jul. PMID 2542606, Free PMC Article
    3. Emergence of the ZNF91 Krüppel-associated box-containing zinc finger gene family in the last common ancestor of anthropoidea. Bellefroid EJ, et al. Proc Natl Acad Sci U S A, 1995 Nov 7. PMID 7479878, Free PMC Article
    4. Rapid and efficient cloning of cDNAs encoding Krüppel-like zinc finger proteins by degenerate PCR. Agata Y, et al. Gene, 1998 Jun 15. PMID 9630514
    5. Characterization of the mid-foregut transcriptome identifies genes regulated during lung bud induction. Millien G, et al. Gene Expr Patterns, 2008 Jan. PMID 18023262, Free PMC Article

    See all (21) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (2) 

    General gene information

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    Markers

    Homology

    Clone Names

    • KIAA4196

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables DNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables DNA-binding transcription activator activity, RNA polymerase II-specific IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in regulation of DNA-templated transcription IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    zinc finger protein 26
    Names
    protein mKR3
    zinc finger protein 81, related sequence 1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001357809.2 → NP_001344738.1  zinc finger protein 26 isoform a

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) encodes isoform a. Variants 1-4 all encode the same isoform (a).
      Source sequence(s)
      AC171206
      Consensus CDS
      CCDS40543.2
      UniProtKB/TrEMBL
      G3XA08
      Conserved Domains (3) summary
      smart00349
      Location:107 → 165
      KRAB; krueppel associated box
      COG5048
      Location:319 → 754
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:402 → 422
      ZF_C2H2; C2H2 Zn finger [structural motif]

    2. NM_001407538.1 → NP_001394467.1  zinc finger protein 26 isoform a

      Status: VALIDATED

      Source sequence(s)
      AC171206
      UniProtKB/TrEMBL
      G3XA08

    3. NM_001407539.1 → NP_001394468.1  zinc finger protein 26 isoform a

      Status: VALIDATED

      Source sequence(s)
      AC171206
      UniProtKB/TrEMBL
      G3XA08

    4. NM_001407540.1 → NP_001394469.1  zinc finger protein 26 isoform b

      Status: VALIDATED

      Source sequence(s)
      AC171206

    5. NM_001407541.1 → NP_001394470.1  zinc finger protein 26 isoform b

      Status: VALIDATED

      Source sequence(s)
      AC171206

    6. NM_001407542.1 → NP_001394471.1  zinc finger protein 26 isoform b

      Status: VALIDATED

      Source sequence(s)
      AC171206

    7. NM_001407543.1 → NP_001394472.1  zinc finger protein 26 isoform c

      Status: VALIDATED

      Source sequence(s)
      AC171206

    8. NM_001407544.1 → NP_001394473.1  zinc finger protein 26 isoform c

      Status: VALIDATED

      Source sequence(s)
      AC171206

    9. NM_001407545.1 → NP_001394474.1  zinc finger protein 26 isoform d

      Status: VALIDATED

      Source sequence(s)
      AC171206

    10. NM_001407546.1 → NP_001394475.1  zinc finger protein 26 isoform d

      Status: VALIDATED

      Source sequence(s)
      AC171206

    11. NM_001407547.1 → NP_001394476.1  zinc finger protein 26 isoform e

      Status: VALIDATED

      Source sequence(s)
      AC171206

    12. NM_001407548.1 → NP_001394477.1  zinc finger protein 26 isoform e

      Status: VALIDATED

      Source sequence(s)
      AC171206

    13. NM_001407549.1 → NP_001394478.1  zinc finger protein 26 isoform e

      Status: VALIDATED

      Source sequence(s)
      AC171206

    14. NM_001407550.1 → NP_001394479.1  zinc finger protein 26 isoform e

      Status: VALIDATED

      Source sequence(s)
      AC171206

    15. NM_011753.4 → NP_035883.2  zinc finger protein 26 isoform a

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Variants 1-4 all encode the same isoform (a).
      Source sequence(s)
      AC171206
      Consensus CDS
      CCDS40543.2
      UniProtKB/TrEMBL
      G3XA08
      Related
      ENSMUSP00000124075.2, ENSMUST00000159569.9
      Conserved Domains (3) summary
      smart00349
      Location:107 → 165
      KRAB; krueppel associated box
      COG5048
      Location:319 → 754
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:402 → 422
      ZF_C2H2; C2H2 Zn finger [structural motif]

    RNA

    1. NR_176386.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AC171206

    2. NR_176387.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AC171206

    3. NR_176388.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AC171206

    4. NR_176389.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AC171206

    5. NR_176390.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AC171206

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000075.7 Reference GRCm39 C57BL/6J

      Range
      20338457..20371465 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_030244255.2 → XP_030100115.1  zinc finger protein 26 isoform X6

      Conserved Domains (3) summary
      COG5048
      Location:92 → 523
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:40 → 60
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam13465
      Location:528 → 552
      zf-H2C2_2; Zinc-finger double domain

    2. XM_011242456.3 → XP_011240758.1  zinc finger protein 26 isoform X2

      UniProtKB/TrEMBL
      G3XA08
      Conserved Domains (3) summary
      smart00349
      Location:107 → 165
      KRAB; krueppel associated box
      COG5048
      Location:319 → 754
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:402 → 422
      ZF_C2H2; C2H2 Zn finger [structural motif]

    3. XM_011242454.4 → XP_011240756.1  zinc finger protein 26 isoform X1

      Conserved Domains (3) summary
      smart00349
      Location:113 → 171
      KRAB; krueppel associated box
      COG5048
      Location:325 → 760
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:408 → 428
      ZF_C2H2; C2H2 Zn finger [structural motif]

    4. XM_011242453.3 → XP_011240755.1  zinc finger protein 26 isoform X1

      Conserved Domains (3) summary
      smart00349
      Location:113 → 171
      KRAB; krueppel associated box
      COG5048
      Location:325 → 760
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:408 → 428
      ZF_C2H2; C2H2 Zn finger [structural motif]

    5. XM_017313287.3 → XP_017168776.1  zinc finger protein 26 isoform X3

      Conserved Domains (3) summary
      smart00349
      Location:85 → 143
      KRAB; krueppel associated box
      COG5048
      Location:297 → 732
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:380 → 400
      ZF_C2H2; C2H2 Zn finger [structural motif]
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P10076.2 GenPept UniProtKB/Swiss-Prot:P10076

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