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    PIGK phosphatidylinositol glycan anchor biosynthesis class K [ Homo sapiens (human) ]

    Gene ID: 10026, updated on 9-Dec-2024

    Summary

    Official Symbol
    PIGKprovided by HGNC
    Official Full Name
    phosphatidylinositol glycan anchor biosynthesis class Kprovided by HGNC
    Primary source
    HGNC:HGNC:8965
    See related
    Ensembl:ENSG00000142892 MIM:605087; AllianceGenome:HGNC:8965
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    GPI8; NEDHCAS
    Summary
    This gene encodes a member of the cysteine protease family C13 that is involved in glycosylphosphatidylinositol (GPI)-anchor biosynthesis. The GPI-anchor is a glycolipid found on many blood cells and serves to anchor proteins to the cell surface. This protein is a member of the multisubunit enzyme, GPI transamidase and is thought to be its enzymatic component. GPI transamidase mediates GPI anchoring in the endoplasmic reticulum, by catalyzing the transfer of fully assembled GPI units to proteins. [provided by RefSeq, Jul 2008]
    Expression
    Ubiquitous expression in thyroid (RPKM 12.4), adrenal (RPKM 9.0) and 25 other tissues See more
    Orthologs
    NEW
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    Genomic context

    See PIGK in Genome Data Viewer
    Location:
    1p31.1
    Exon count:
    11
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 1 NC_000001.11 (77088989..77219430, complement)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 1 NC_060925.1 (76927170..77057594, complement)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (77554674..77685115, complement)

    Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene NANOG hESC enhancer GRCh37_chr1:77231962-77232537 Neighboring gene long intergenic non-protein coding RNA 2567 Neighboring gene MPRA-validated peak293 silencer Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr1:77319872-77320409 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 1212 Neighboring gene ST6 N-acetylgalactosaminide alpha-2,6-sialyltransferase 5 Neighboring gene NANOG hESC enhancer GRCh37_chr1:77365662-77366201 Neighboring gene NANOG hESC enhancer GRCh37_chr1:77426151-77426652 Neighboring gene MPRA-validated peak295 silencer Neighboring gene P300/CBP strongly-dependent group 1 enhancer GRCh37_chr1:77463853-77465052 Neighboring gene NANOG-H3K4me1 hESC enhancer GRCh37_chr1:77489814-77490314 Neighboring gene MPRA-validated peak297 silencer Neighboring gene ATAC-STARR-seq lymphoblastoid active region 1213 Neighboring gene microRNA 7156 Neighboring gene ribosomal protein L17 pseudogene 6 Neighboring gene alanyl-tRNA synthetase domain containing 1 pseudogene Neighboring gene ATAC-STARR-seq lymphoblastoid active region 1214 Neighboring gene uncharacterized LOC105378808 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr1:77730892-77731409 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 1001 Neighboring gene H3K27ac hESC enhancer GRCh37_chr1:77777635-77778136 Neighboring gene Sharpr-MPRA regulatory region 3902 Neighboring gene adenylate kinase 5 Neighboring gene RNA, U7 small nuclear 8 pseudogene

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    HIV-1 interactions

    Replication interactions

    Interaction Pubs
    Knockdown of phosphatidylinositol glycan anchor biosynthesis, class K (PIGK) by siRNA inhibits HIV-1 replication in HeLa-derived TZM-bl cells PubMed

    Protein interactions

    Protein Gene Interaction Pubs
    Envelope surface glycoprotein gp160, precursor env HIV-1 gp160 interacts with PIGK; predicted interaction to be within the endoplasmic reticulum PubMed

    Go to the HIV-1, Human Interaction Database

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Clone Names

    • MGC22559

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    contributes_to GPI anchor binding TAS
    Traceable Author Statement
    more info
    PubMed 
    enables GPI-anchor transamidase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables GPI-anchor transamidase activity IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    enables GPI-anchor transamidase activity TAS
    Traceable Author Statement
    more info
     
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables protein disulfide isomerase activity TAS
    Traceable Author Statement
    more info
    PubMed 
    Process Evidence Code Pubs
    involved_in GPI anchor biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in attachment of GPI anchor to protein IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in attachment of GPI anchor to protein NAS
    Non-traceable Author Statement
    more info
    PubMed 
    involved_in attachment of GPI anchor to protein TAS
    Traceable Author Statement
    more info
    PubMed 
    involved_in proteolysis IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    part_of GPI-anchor transamidase complex IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    part_of GPI-anchor transamidase complex IDA
    Inferred from Direct Assay
    more info
    PubMed 
    part_of GPI-anchor transamidase complex IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    part_of GPI-anchor transamidase complex IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    located_in endoplasmic reticulum membrane NAS
    Non-traceable Author Statement
    more info
    PubMed 
    located_in endoplasmic reticulum membrane TAS
    Traceable Author Statement
    more info
     
    located_in membrane HDA PubMed 

    General protein information

    Preferred Names
    GPI-anchor transamidase
    Names
    GPI transamidase subunit
    GPI8 homolog
    PIG-K
    phosphatidylinositol glycan, class K
    phosphatidylinositol-glycan biosynthesis class K protein
    NP_005473.1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_005482.3NP_005473.1  GPI-anchor transamidase precursor

      See identical proteins and their annotated locations for NP_005473.1

      Status: REVIEWED

      Source sequence(s)
      AC093433, AC113935, AL035409
      Consensus CDS
      CCDS674.1
      UniProtKB/Swiss-Prot
      B2R7K3, B4E2M3, O14822, Q5TG77, Q92643
      UniProtKB/TrEMBL
      A6NEM5
      Related
      ENSP00000359848.3, ENST00000370812.8
      Conserved Domains (1) summary
      cl00042
      Location:42331
      CASc; Caspase, interleukin-1 beta converting enzyme (ICE) homologues; Cysteine-dependent aspartate-directed proteases that mediate programmed cell death (apoptosis). Caspases are synthesized as inactive zymogens and activated by proteolysis of the peptide ...

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000001.11 Reference GRCh38.p14 Primary Assembly

      Range
      77088989..77219430 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060925.1 Alternate T2T-CHM13v2.0

      Range
      76927170..77057594 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)