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    TALDO1 transaldolase 1 [ Homo sapiens (human) ]

    Gene ID: 6888, updated on 9-Dec-2024

    Summary

    Official Symbol
    TALDO1provided by HGNC
    Official Full Name
    transaldolase 1provided by HGNC
    Primary source
    HGNC:HGNC:11559
    See related
    Ensembl:ENSG00000177156 MIM:602063; AllianceGenome:HGNC:11559
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    TAL; TALH; TAL-H; TALDOR
    Summary
    Transaldolase 1 is a key enzyme of the nonoxidative pentose phosphate pathway providing ribose-5-phosphate for nucleic acid synthesis and NADPH for lipid biosynthesis. This pathway can also maintain glutathione at a reduced state and thus protect sulfhydryl groups and cellular integrity from oxygen radicals. The functional gene of transaldolase 1 is located on chromosome 11 and a pseudogene is identified on chromosome 1 but there are conflicting map locations. The second and third exon of this gene were developed by insertion of a retrotransposable element. This gene is thought to be involved in multiple sclerosis. [provided by RefSeq, Jul 2008]
    Expression
    Ubiquitous expression in bone marrow (RPKM 165.6), esophagus (RPKM 127.9) and 25 other tissues See more
    Orthologs
    NEW
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    Genomic context

    See TALDO1 in Genome Data Viewer
    Location:
    11p15.5
    Exon count:
    8
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 11 NC_000011.10 (747464..765012)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 11 NC_060935.1 (798942..816524)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 11 NC_000011.9 (747464..765012)

    Chromosome 11 - NC_000011.10Genomic Context describing neighboring genes Neighboring gene DEAF1 transcription factor Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr11:706927-707853 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr11:707854-708781 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr11:709709-710636 Neighboring gene EPS8 signaling adaptor L2 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 3016 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 3017 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 3018 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 3019 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 3020 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 3021 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr11:727187-728092 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 3022 Neighboring gene H3K27ac hESC enhancer GRCh37_chr11:734652-735152 Neighboring gene H3K27ac hESC enhancer GRCh37_chr11:735153-735653 Neighboring gene uncharacterized LOC105376509 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr11:742971-743670 Neighboring gene OCT4-NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr11:743671-744369 Neighboring gene hESC enhancers GRCh37_chr11:746448-747096 and GRCh37_chr11:747097-747745 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 3025 Neighboring gene CDK7 strongly-dependent group 2 enhancer GRCh37_chr11:762588-763787 Neighboring gene ReSE screen-validated silencer GRCh37_chr11:765339-765752 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 3026 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 3027 Neighboring gene uncharacterized LOC124900301 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 3028 Neighboring gene glutamine amidotransferase class 1 domain containing 1 Neighboring gene GATD1 divergent transcript

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables monosaccharide binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables transaldolase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables transaldolase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables transaldolase activity IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    Process Evidence Code Pubs
    involved_in carbohydrate metabolic process IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in fructose 6-phosphate metabolic process IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in pentose-phosphate shunt, non-oxidative branch IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in pentose-phosphate shunt, non-oxidative branch IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    Component Evidence Code Pubs
    located_in cytoplasm TAS
    Traceable Author Statement
    more info
    PubMed 
    located_in cytosol IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in cytosol TAS
    Traceable Author Statement
    more info
     
    located_in extracellular exosome HDA PubMed 
    located_in nucleus HDA PubMed 
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
     

    General protein information

    Preferred Names
    transaldolase
    Names
    dihydroxyacetone transferase
    glycerone transferase
    testicular secretory protein Li 56
    NP_006746.1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_008160.1 RefSeqGene

      Range
      5033..22581
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_006755.2NP_006746.1  transaldolase

      See identical proteins and their annotated locations for NP_006746.1

      Status: REVIEWED

      Source sequence(s)
      L19437
      Consensus CDS
      CCDS7712.1
      UniProtKB/Swiss-Prot
      B2R8M2, O00751, P37837, Q8WV32, Q8WZ45
      UniProtKB/TrEMBL
      A0A140VK56, F2Z393
      Related
      ENSP00000321259.3, ENST00000319006.8
      Conserved Domains (1) summary
      PRK05269
      Location:11329
      PRK05269; transaldolase B; Provisional

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000011.10 Reference GRCh38.p14 Primary Assembly

      Range
      747464..765012
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060935.1 Alternate T2T-CHM13v2.0

      Range
      798942..816524
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)