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    PRSS3 serine protease 3 [ Homo sapiens (human) ]

    Gene ID: 5646, updated on 3-Dec-2024

    Summary

    Official Symbol
    PRSS3provided by HGNC
    Official Full Name
    serine protease 3provided by HGNC
    Primary source
    HGNC:HGNC:9486
    See related
    Ensembl:ENSG00000010438 MIM:613578; AllianceGenome:HGNC:9486
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    T9; MTG; TRY3; TRY4; PRSS4
    Summary
    This gene encodes a trypsinogen, which is a member of the trypsin family of serine proteases. This enzyme is expressed in the brain and pancreas and is resistant to common trypsin inhibitors. It is active on peptide linkages involving the carboxyl group of lysine or arginine. This gene is localized to the locus of T cell receptor beta variable orphans on chromosome 9. Four transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, Oct 2010]
    Expression
    Restricted expression toward pancreas (RPKM 3091.3) See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See PRSS3 in Genome Data Viewer
    Location:
    9p13.3
    Exon count:
    8
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 9 NC_000009.12 (33750679..33799231)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 9 NC_060933.1 (33769262..33817820)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 9 NC_000009.11 (33750677..33799229)

    Chromosome 9 - NC_000009.12Genomic Context describing neighboring genes Neighboring gene T cell receptor beta variable 26/OR9-2 (pseudogene) Neighboring gene uncharacterized LOC124902143 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 28300 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr9:33721507-33722008 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr9:33722009-33722508 Neighboring gene UBE2R2 antisense RNA 1 Neighboring gene MPRA-validated peak7221 silencer Neighboring gene ATAC-STARR-seq lymphoblastoid active region 28301 Neighboring gene T cell receptor beta variable 29/OR9-2 (non-functional) Neighboring gene H3K4me1 hESC enhancer GRCh37_chr9:33796108-33796608 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 28302 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 19835 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 19836 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 19837 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 19838 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 19839 Neighboring gene ubiquitin conjugating enzyme E2 R2 Neighboring gene RNA, U4atac small nuclear 11, pseudogene Neighboring gene ATAC-STARR-seq lymphoblastoid active region 28303 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr9:33927431-33928421 Neighboring gene small nucleolar RNA, C/D box 121B Neighboring gene ubiquitin associated protein 2

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Phenotypes

    EBI GWAS Catalog

    Description
    Collaborative genome-wide association analysis supports a role for ANK3 and CACNA1C in bipolar disorder.
    EBI GWAS Catalog

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables calcium ion binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables serine-type endopeptidase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables serine-type endopeptidase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables serine-type peptidase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables serine-type peptidase activity TAS
    Traceable Author Statement
    more info
     
    Process Evidence Code Pubs
    involved_in antimicrobial humoral response TAS
    Traceable Author Statement
    more info
     
    involved_in digestion TAS
    Traceable Author Statement
    more info
    PubMed 
    involved_in endothelial cell migration IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in proteolysis IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in proteolysis IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in proteolysis NAS
    Non-traceable Author Statement
    more info
    PubMed 
    involved_in zymogen activation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    Component Evidence Code Pubs
    located_in extracellular region TAS
    Traceable Author Statement
    more info
     
    is_active_in extracellular space IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in extracellular space IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in tertiary granule lumen TAS
    Traceable Author Statement
    more info
     

    General protein information

    Preferred Names
    trypsin-3
    Names
    brain trypsinogen
    mesotrypsin
    mesotrypsinogen
    pancreatic trypsinogen III
    protease, serine 3
    protease, serine, 4 (trypsin 4, brain)
    trypsin III
    trypsin IV
    trypsinogen 4
    trypsinogen 5
    trypsinogen IV
    NP_001184026.3
    NP_001184027.1
    NP_002762.3
    NP_031369.3
    XP_011516267.2
    XP_047279558.1
    XP_054219277.1
    XP_054219278.1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_001337.2 

      Range
      144006..192771
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    2. NG_029635.2 RefSeqGene

      Range
      49884..53554
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001197097.3NP_001184026.3  trypsin-3 isoform 3 preproprotein

      Status: REVIEWED

      Description
      Transcript Variant: This variant (3) contains an alternate in-frame exon in the 5' coding region and uses a downstream start codon, compared to variant 1. The resulting protein (isoform 3) has a shorter N-terminus, compared to isoform 1.
      Source sequence(s)
      AL139113, AL356489, AL358573
      UniProtKB/TrEMBL
      A0A7P0MNE9
      Related
      ENSP00000340889.5, ENST00000342836.9
      Conserved Domains (1) summary
      cd00190
      Location:38256
      Tryp_SPc; Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad ...
    2. NM_001197098.1NP_001184027.1  trypsin-3 isoform 4 preproprotein

      See identical proteins and their annotated locations for NP_001184027.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (4) contains a different in-frame first exon and uses an alternate start codon, compared to variant 1. The resulting protein (isoform 4) has a shorter and distinct N-terminus, compared to isoform 1.
      Source sequence(s)
      AB298286
      Consensus CDS
      CCDS56570.1
      UniProtKB/TrEMBL
      Q8N2U3
      Related
      ENSP00000401828.3, ENST00000429677.8
      Conserved Domains (2) summary
      smart00020
      Location:16232
      Tryp_SPc; Trypsin-like serine protease
      cd00190
      Location:17235
      Tryp_SPc; Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad ...
    3. NM_002771.4NP_002762.3  trypsin-3 isoform 2 preproprotein

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR and 5' coding region compared to variant 1. The resulting isoform (2) has a distinct N-terminus and is shorter than isoform 1.
      Source sequence(s)
      AL139113, AL358573
      Consensus CDS
      CCDS6545.1
      UniProtKB/TrEMBL
      A1A508
      Related
      ENSP00000368715.3, ENST00000379405.4
      Conserved Domains (1) summary
      cd00190
      Location:24242
      Tryp_SPc; Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad ...
    4. NM_007343.4NP_031369.3  trypsin-3 isoform 1 preproprotein

      Status: REVIEWED

      Source sequence(s)
      AL139113, AL356489, AL358573
      Consensus CDS
      CCDS47958.2
      UniProtKB/TrEMBL
      A0A7P0MP65
      Related
      ENSP00000354280.6, ENST00000361005.10
      Conserved Domains (1) summary
      cd00190
      Location:1134
      Tryp_SPc; Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad ...

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000009.12 Reference GRCh38.p14 Primary Assembly

      Range
      33750679..33799231
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_011517965.2XP_011516267.2  trypsin-3 isoform X1

      UniProtKB/TrEMBL
      A0A7P0MP65
    2. XM_047423602.1XP_047279558.1  trypsin-3 isoform X2

      UniProtKB/TrEMBL
      A1A508

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060933.1 Alternate T2T-CHM13v2.0

      Range
      33769262..33817820
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054363302.1XP_054219277.1  trypsin-3 isoform X2

      UniProtKB/TrEMBL
      A1A508
    2. XM_054363303.1XP_054219278.1  trypsin-3 isoform X2

      UniProtKB/TrEMBL
      A1A508