U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Links from GEO Profiles

    • Showing Current items.

    MRPL32 mitochondrial ribosomal protein L32 [ Homo sapiens (human) ]

    Gene ID: 64983, updated on 27-Nov-2024

    Summary

    Official Symbol
    MRPL32provided by HGNC
    Official Full Name
    mitochondrial ribosomal protein L32provided by HGNC
    Primary source
    HGNC:HGNC:14035
    See related
    Ensembl:ENSG00000106591 MIM:611839; AllianceGenome:HGNC:14035
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    L32mt; bL32m; HSPC283; MRP-L32; bMRP-59b
    Summary
    Mammalian mitochondrial ribosomal proteins are encoded by nuclear genes and help in protein synthesis within the mitochondrion. Mitochondrial ribosomes (mitoribosomes) consist of a small 28S subunit and a large 39S subunit. They have an estimated 75% protein to rRNA composition compared to prokaryotic ribosomes, where this ratio is reversed. Another difference between mammalian mitoribosomes and prokaryotic ribosomes is that the latter contain a 5S rRNA. Among different species, the proteins comprising the mitoribosome differ greatly in sequence, and sometimes in biochemical properties, which prevents easy recognition by sequence homology. This gene encodes a 39S subunit protein that belongs to the L32 ribosomal protein family. A pseudogene corresponding to this gene is found on chromosome Xp. [provided by RefSeq, Jul 2008]
    Expression
    Ubiquitous expression in adrenal (RPKM 30.6), kidney (RPKM 28.9) and 25 other tissues See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See MRPL32 in Genome Data Viewer
    Location:
    7p14.1
    Exon count:
    4
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 7 NC_000007.14 (42932376..42937857)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 7 NC_060931.1 (43090506..43095986)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 7 NC_000007.13 (42971975..42977456)

    Chromosome 7 - NC_000007.14Genomic Context describing neighboring genes Neighboring gene H3K27ac hESC enhancer GRCh37_chr7:42950498-42951195 Neighboring gene H3K27ac hESC enhancer GRCh37_chr7:42951196-42951892 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 25904 Neighboring gene serine-threonine kinase receptor-associated protein-like Neighboring gene chromosome 7 open reading frame 25 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 25905 Neighboring gene proteasome 20S subunit alpha 2 Neighboring gene uncharacterized LOC105375253 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 25906 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 25907 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr7:43086257-43086757 Neighboring gene Sharpr-MPRA regulatory region 4044 Neighboring gene OCT4-NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr7:43098985-43099585 Neighboring gene uncharacterized LOC107986790 Neighboring gene Sharpr-MPRA regulatory region 5110

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables RNA binding HDA PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables structural constituent of ribosome IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables structural constituent of ribosome NAS
    Non-traceable Author Statement
    more info
    PubMed 
    Process Evidence Code Pubs
    involved_in mitochondrial translation NAS
    Non-traceable Author Statement
    more info
    PubMed 
    involved_in translation NAS
    Non-traceable Author Statement
    more info
    PubMed 

    General protein information

    Preferred Names
    large ribosomal subunit protein bL32m
    Names
    39S ribosomal protein L32, mitochondrial
    mitochondrial large ribosomal subunit protein bL32m
    NP_114109.1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_031903.3NP_114109.1  large ribosomal subunit protein bL32m precursor

      See identical proteins and their annotated locations for NP_114109.1

      Status: REVIEWED

      Source sequence(s)
      AC010132
      Consensus CDS
      CCDS5468.1
      UniProtKB/Swiss-Prot
      Q96Q68, Q9BYC8, Q9P098
      UniProtKB/TrEMBL
      A4D1V4
      Related
      ENSP00000223324.2, ENST00000223324.3
      Conserved Domains (1) summary
      pfam01783
      Location:79126
      Ribosomal_L32p; Ribosomal L32p protein family

    RNA

    1. NR_156497.1 RNA Sequence

      Status: REVIEWED

      Source sequence(s)
      AB049649, AC010132, AW379023, BM833110, BU687817

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000007.14 Reference GRCh38.p14 Primary Assembly

      Range
      42932376..42937857
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060931.1 Alternate T2T-CHM13v2.0

      Range
      43090506..43095986
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)