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    CLIC1 chloride intracellular channel 1 [ Homo sapiens (human) ]

    Gene ID: 1192, updated on 27-Nov-2024

    Summary

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    Official Symbol
    CLIC1provided by HGNC
    Official Full Name
    chloride intracellular channel 1provided by HGNC
    Primary source
    HGNC:HGNC:2062
    See related
    Ensembl:ENSG00000213719 MIM:602872; AllianceGenome:HGNC:2062
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    G6; CL1C1; NCC27; CLCNL1
    Summary
    Chloride channels are a diverse group of proteins that regulate fundamental cellular processes including stabilization of cell membrane potential, transepithelial transport, maintenance of intracellular pH, and regulation of cell volume. Chloride intracellular channel 1 is a member of the p64 family; the protein localizes principally to the cell nucleus and exhibits both nuclear and plasma membrane chloride ion channel activity. [provided by RefSeq, Jul 2008]
    Expression
    Ubiquitous expression in placenta (RPKM 110.8), bone marrow (RPKM 106.5) and 25 other tissues See more
    Orthologs
    mouse all
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    Genomic context

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    See CLIC1 in Genome Data Viewer
    Location:
    6p21.33
    Exon count:
    8
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 6 NC_000006.12 (31730581..31737318, complement)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 6 NC_060930.1 (31583614..31590355, complement)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 6 NC_000006.11 (31698358..31705095, complement)

    Chromosome 6 - NC_000006.12Genomic Context describing neighboring genes Neighboring gene lymphocyte antigen 6 family member G6C Neighboring gene megakaryocyte and platelet inhibitory receptor G6b Neighboring gene DDAH family member 2, ADMA-independent Neighboring gene MED14-independent group 3 enhancer GRCh37_chr6:31701615-31702814 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr6:31704508-31705382 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr6:31707224-31707854 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr6:31707855-31708486 Neighboring gene MSH5-SAPCD1 readthrough (NMD candidate) Neighboring gene mutS homolog 5 Neighboring gene RNA, U6 small nuclear 850, pseudogene Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr6:31731027-31731582 Neighboring gene SAPCD1 antisense RNA 1 Neighboring gene suppressor APC domain containing 1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    Related articles in PubMed

    1. MtHsp70-CLIC1-pulsed dendritic cells enhance the immune response against ovarian cancer. Yu W, et al. Biochem Biophys Res Commun, 2017 Dec 9. PMID 29061300
    2. Chloride intracellular channel 1 regulates colon cancer cell migration and invasion through ROS/ERK pathway. Wang P, et al. World J Gastroenterol, 2014 Feb 28. PMID 24587680, Free PMC Article
    3. Quantitative proteomic profiling of pleomorphic human sarcoma identifies CLIC1 as a dominant pro-oncogenic receptor expressed in diverse sarcoma types. Murray E, et al. J Proteome Res, 2014 May 2. PMID 24661138
    4. Chloride intracellular channel 1 participates in migration and invasion of hepatocellular carcinoma by targeting maspin. Wei X, et al. J Gastroenterol Hepatol, 2015 Jan. PMID 24989236
    5. Glutamate 85 and glutamate 228 contribute to the pH-response of the soluble form of chloride intracellular channel 1. Cross M, et al. Mol Cell Biochem, 2015 Jan. PMID 25209805

    See all (213) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. A CLIC1 network coordinates matrix stiffness and the Warburg effect to promote tumor growth in pancreatic cancer.
      Title: A CLIC1 network coordinates matrix stiffness and the Warburg effect to promote tumor growth in pancreatic cancer.
    2. Chloride Intracellular Channel Protein 1 (CLIC1) Is a Critical Host Cellular Factor for Influenza A Virus Replication.
      Title: Chloride Intracellular Channel Protein 1 (CLIC1) Is a Critical Host Cellular Factor for Influenza A Virus Replication.
    3. CLIC1-mediated autophagy confers resistance to DDP in gastric cancer.
      Title: CLIC1-mediated autophagy confers resistance to DDP in gastric cancer.
    4. Comprehensive analysis of clinical prognosis and CLIC1 immune invasion in lung adenocarcinoma.
      Title: Comprehensive analysis of clinical prognosis and CLIC1 immune invasion in lung adenocarcinoma.
    5. CLIC1 promotes the progression of cervical cancer through the PTEN/PI3K/AKT pathway.
      Title: CLIC1 promotes the progression of cervical cancer through the PTEN/PI3K/AKT pathway.
    6. CLIC1 Drives Angiogenesis in Hepatocellular Carcinoma by Modulating VEGFA.
      Title: CLIC1 Drives Angiogenesis in Hepatocellular Carcinoma by Modulating VEGFA.
    7. Chloride Intracellular Channel 1 Expression Is Associated With Poor Prognosis of Lung Adenocarcinoma.
      Title: Chloride Intracellular Channel 1 Expression Is Associated With Poor Prognosis of Lung Adenocarcinoma.
    8. Identification of chloride intracellular channels as prognostic factors correlated with immune infiltration in hepatocellular carcinoma using bioinformatics analysis.
      Title: Identification of chloride intracellular channels as prognostic factors correlated with immune infiltration in hepatocellular carcinoma using bioinformatics analysis.
    9. Acetylation-stabilized chloride intracellular channel 1 exerts a tumor-promoting effect on cervical cancer cells by activating NF-kappaB.
      Title: Acetylation-stabilized chloride intracellular channel 1 exerts a tumor-promoting effect on cervical cancer cells by activating NF-κB.
    10. PD_BiBIM: Biclustering-based biomarker identification in ESCC microarray data.
      Title: PD_BiBIM: Biclustering-based biomarker identification in ESCC microarray data.
    Submit: New GeneRIF Correction See all GeneRIFs (86)

    Phenotypes

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    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    HIV-1 interactions

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    Protein interactions

    Protein Gene Interaction Pubs
    Tat tat Expression of HIV-1 Tat upregulates the abundance of chloride intracellular channel 1 (CLIC1) in the nucleoli of Jurkat T-cells PubMed
    Vpr vpr A stable-isotope labeling by amino acids in cell culture coupled with mass spectrometry-based proteomics identifies downregulation of chloride intracellular channel 1 (CLIC1) expression by HIV-1 Vpr in Vpr transduced macrophages PubMed

    Go to the HIV-1, Human Interaction Database

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables cadherin binding HDA PubMed 
    enables chloride channel activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables chloride channel activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables oxidoreductase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in chloride transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in chloride transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within chloride transport IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in platelet aggregation HMP PubMed 
    involved_in positive regulation of osteoblast differentiation IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in regulation of mitochondrial membrane potential IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in signal transduction TAS
    Traceable Author Statement
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in blood microparticle HDA PubMed 
    located_in brush border TAS
    Traceable Author Statement
    more info
    		 PubMed 
    part_of chloride channel complex IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytoplasm HDA PubMed 
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in endoplasmic reticulum IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in extracellular exosome HDA PubMed 
    located_in extracellular exosome IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in extracellular space HDA PubMed 
    located_in membrane HDA PubMed 
    is_active_in membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in mitochondrion IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nuclear envelope IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nuclear membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleus HDA PubMed 
    located_in nucleus TAS
    Traceable Author Statement
    more info
    		 PubMed 
    located_in perinuclear region of cytoplasm IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in vesicle HDA PubMed 

    General protein information

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    Preferred Names
    chloride intracellular channel protein 1
    Names
    RNCC protein
    chloride channel ABP
    glutaredoxin-like oxidoreductase CLIC1
    glutathione-dependent dehydroascorbate reductase CLIC1
    hRNCC
    nuclear chloride ion channel 27
    nuclear chloride ion channel protein
    p64CLCP
    regulatory nuclear chloride ion channel protein
    NP_001274522.1
    NP_001274523.1
    NP_001279.2

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001287593.1 → NP_001274522.1  chloride intracellular channel protein 1

      See identical proteins and their annotated locations for NP_001274522.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) represents the longest transcript. Variants 1, 2 and 3 encode the same protein.
      Source sequence(s)
      BC064527
      Consensus CDS
      CCDS4719.1
      UniProtKB/Swiss-Prot
      O00299, Q15089, Q502X1
      UniProtKB/TrEMBL
      Q53FB0, Q5SRT3
      Related
      ENSP00000364935.2, ENST00000375780.6
      Conserved Domains (1) summary
      TIGR00862
      Location:6 → 241
      O-ClC; intracellular chloride channel protein

    2. NM_001287594.3 → NP_001274523.1  chloride intracellular channel protein 1

      See identical proteins and their annotated locations for NP_001274523.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (3) has an alternate exon in the 5' UTR compared to variant 1. Variants 1, 2 and 3 encode the same protein.
      Source sequence(s)
      AL662899
      Consensus CDS
      CCDS4719.1
      UniProtKB/Swiss-Prot
      O00299, Q15089, Q502X1
      UniProtKB/TrEMBL
      Q53FB0, Q5SRT3
      Related
      ENSP00000479808.1, ENST00000616760.1
      Conserved Domains (1) summary
      TIGR00862
      Location:6 → 241
      O-ClC; intracellular chloride channel protein

    3. NM_001288.6 → NP_001279.2  chloride intracellular channel protein 1

      See identical proteins and their annotated locations for NP_001279.2

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) has an alternate exon in the 5' UTR compared to variant 1. Variants 1, 2 and 3 encode the same protein.
      Source sequence(s)
      AL662899
      Consensus CDS
      CCDS4719.1
      UniProtKB/Swiss-Prot
      O00299, Q15089, Q502X1
      UniProtKB/TrEMBL
      Q53FB0, Q5SRT3
      Related
      ENSP00000364940.3, ENST00000375784.8
      Conserved Domains (1) summary
      TIGR00862
      Location:6 → 241
      O-ClC; intracellular chloride channel protein

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000006.12 Reference GRCh38.p14 Primary Assembly

      Range
      31730581..31737318 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Reference GRCh38.p14 ALT_REF_LOCI_2

    Genomic

    1. NT_113891.3 Reference GRCh38.p14 ALT_REF_LOCI_2

      Range
      3207869..3214610 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Reference GRCh38.p14 ALT_REF_LOCI_3

    Genomic

    1. NT_167245.2 Reference GRCh38.p14 ALT_REF_LOCI_3

      Range
      2978342..2985081 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Reference GRCh38.p14 ALT_REF_LOCI_4

    Genomic

    1. NT_167246.2 Reference GRCh38.p14 ALT_REF_LOCI_4

      Range
      3035628..3042369 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Reference GRCh38.p14 ALT_REF_LOCI_5

    Genomic

    1. NT_167247.2 Reference GRCh38.p14 ALT_REF_LOCI_5

      Range
      3072456..3079197 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Reference GRCh38.p14 ALT_REF_LOCI_6

    Genomic

    1. NT_167248.2 Reference GRCh38.p14 ALT_REF_LOCI_6

      Range
      2986392..2993137 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Reference GRCh38.p14 ALT_REF_LOCI_7

    Genomic

    1. NT_167249.2 Reference GRCh38.p14 ALT_REF_LOCI_7

      Range
      3029877..3036620 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060930.1 Alternate T2T-CHM13v2.0

      Range
      31583614..31590355 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    O00299.4 GenPept UniProtKB/Swiss-Prot:O00299

    Gene LinkOut

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