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    Zfyve21 zinc finger, FYVE domain containing 21 [ Mus musculus (house mouse) ]

    Gene ID: 68520, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Zfyve21provided by MGI
    Official Full Name
    zinc finger, FYVE domain containing 21provided by MGI
    Primary source
    MGI:MGI:1915770
    See related
    Ensembl:ENSMUSG00000021286 AllianceGenome:MGI:1915770
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    1110013H04Rik
    Summary
    Predicted to enable metal ion binding activity. Predicted to be located in endosome and focal adhesion. Is expressed in several structures, including brain; cardiovascular system; genitourinary system; gut; and liver and biliary system. Orthologous to human ZFYVE21 (zinc finger FYVE-type containing 21). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Ubiquitous expression in genital fat pad adult (RPKM 52.9), ovary adult (RPKM 50.4) and 28 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Zfyve21 in Genome Data Viewer
    Location:
    12 F1; 12 61.14 cM
    Exon count:
    9
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 12 NC_000078.7 (111780600..111794822)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 12 NC_000078.6 (111814166..111828388)

    Chromosome 12 - NC_000078.7Genomic Context describing neighboring genes Neighboring gene BCL2-associated athanogene 5 Neighboring gene cytochrome c oxidase assembly factor 8 Neighboring gene STARR-seq mESC enhancer starr_33333 Neighboring gene STARR-positive B cell enhancer ABC_E7188 Neighboring gene kinesin light chain 1 Neighboring gene STARR-positive B cell enhancer ABC_E209 Neighboring gene X-ray repair complementing defective repair in Chinese hamster cells 3 Neighboring gene protein phosphatase 1, regulatory subunit 13B Neighboring gene predicted gene, 53769 Neighboring gene CapStarr-seq enhancer MGSCv37_chr12:113090021-113090249 Neighboring gene NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, assembly factor 4 pseudogene

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Hedgehog-induced ZFYVE21 promotes chronic vascular inflammation by activating NLRP3 inflammasomes in T cells. Jiang B, et al. Sci Signal, 2023 Mar 21. PMID 36943921, Free PMC Article
    2. ZF21 protein, a regulator of the disassembly of focal adhesions and cancer metastasis, contains a novel noncanonical pleckstrin homology domain. Nagano M, et al. J Biol Chem, 2011 Sep 9. PMID 21768110, Free PMC Article
    3. ZFYVE21 promotes endothelial nitric oxide signaling and vascular barrier function in the kidney during aging. Jiang Q, et al. Kidney Int, 2024 Sep. PMID 38797325,
    4. Database resources of the National Center for Biotechnology Information. Wheeler DL, et al. Nucleic Acids Res, 2001 Jan 1. PMID 11125038, Free PMC Article
    5. The International Mouse Phenotyping Consortium Web Portal, a unified point of access for knockout mice and related phenotyping data. Koscielny G, et al. Nucleic Acids Res, 2014 Jan. PMID 24194600, Free PMC Article

    See all (26) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. ZFYVE21 promotes endothelial nitric oxide signaling and vascular barrier function in the kidney during aging.
      Title: ZFYVE21 promotes endothelial nitric oxide signaling and vascular barrier function in the kidney during aging.
    2. Hedgehog-induced ZFYVE21 promotes chronic vascular inflammation by activating NLRP3 inflammasomes in T cells.
      Title: Hedgehog-induced ZFYVE21 promotes chronic vascular inflammation by activating NLRP3 inflammasomes in T cells.
    3. the C-terminal region is important for the ability of ZF21 to induce disassembly of FAs and cell migration, and to promote an early step of experimental metastasis to the lung
      Title: ZF21 protein, a regulator of the disassembly of focal adhesions and cancer metastasis, contains a novel noncanonical pleckstrin homology domain.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (1) 
    • Targeted (3)  1 citation

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables molecular_function ND
    No biological Data available
    more info
    		  
    Process Evidence Code Pubs
    involved_in biological_process ND
    No biological Data available
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cellular_component ND
    No biological Data available
    more info
    		  
    located_in endosome IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in focal adhesion IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    zinc finger FYVE domain-containing protein 21

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001374721.1 → NP_001361650.1  zinc finger FYVE domain-containing protein 21 isoform 2

      Status: VALIDATED

      Source sequence(s)
      AC152065
      Consensus CDS
      CCDS88408.1
      UniProtKB/TrEMBL
      A0A1Y7VJT0, A0A1Y7VNH4
      Related
      ENSMUSP00000152422.2, ENSMUST00000221375.2
      Conserved Domains (2) summary
      cd15727
      Location:38 → 101
      FYVE_ZF21; FYVE domain found in zinc finger FYVE domain-containing protein 21 (ZF21) and similar proteins
      pfam16696
      Location:108 → 248
      ZFYVE21_C; Zinc finger FYVE domain-containing protein 21 C-terminus

    2. NM_026752.4 → NP_081028.3  zinc finger FYVE domain-containing protein 21 isoform 1

      See identical proteins and their annotated locations for NP_081028.3

      Status: VALIDATED

      Source sequence(s)
      AC152065, BC132248
      Consensus CDS
      CCDS56865.1
      UniProtKB/Swiss-Prot
      A3KML1, Q3TBQ9, Q8VCM3, Q9D1E2
      UniProtKB/TrEMBL
      A0A1Y7VJT0
      Related
      ENSMUSP00000021714.8, ENSMUST00000021714.9
      Conserved Domains (2) summary
      cd15727
      Location:38 → 101
      FYVE_ZF21; FYVE domain found in zinc finger FYVE domain-containing protein 21 (ZF21) and similar proteins
      pfam16696
      Location:108 → 229
      ZFYVE21_C; Zinc finger FYVE domain-containing protein 21 C-terminus

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000078.7 Reference GRCm39 C57BL/6J

      Range
      111780600..111794822
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006516195.4 → XP_006516258.1  zinc finger FYVE domain-containing protein 21 isoform X3

      UniProtKB/TrEMBL
      A0A1Y7VJT0
      Conserved Domains (2) summary
      cd15727
      Location:38 → 101
      FYVE_ZF21; FYVE domain found in zinc finger FYVE domain-containing protein 21 (ZF21) and similar proteins
      pfam16696
      Location:108 → 246
      ZFYVE21_C; Zinc finger FYVE domain-containing protein 21 C-terminus

    2. XM_006516194.4 → XP_006516257.1  zinc finger FYVE domain-containing protein 21 isoform X2

      UniProtKB/TrEMBL
      A0A1Y7VJT0
      Conserved Domains (2) summary
      cd15727
      Location:38 → 101
      FYVE_ZF21; FYVE domain found in zinc finger FYVE domain-containing protein 21 (ZF21) and similar proteins
      pfam16696
      Location:108 → 247
      ZFYVE21_C; Zinc finger FYVE domain-containing protein 21 C-terminus

    3. XM_006516193.4 → XP_006516256.1  zinc finger FYVE domain-containing protein 21 isoform X1

      UniProtKB/TrEMBL
      A0A1Y7VJT0
      Related
      ENSMUSP00000152558.2, ENSMUST00000223211.2
      Conserved Domains (2) summary
      cd15727
      Location:38 → 101
      FYVE_ZF21; FYVE domain found in zinc finger FYVE domain-containing protein 21 (ZF21) and similar proteins
      pfam16696
      Location:108 → 247
      ZFYVE21_C; Zinc finger FYVE domain-containing protein 21 C-terminus

    4. XM_011244168.2 → XP_011242470.1  zinc finger FYVE domain-containing protein 21 isoform X4

      UniProtKB/TrEMBL
      A0A1Y7VJT0
      Conserved Domains (2) summary
      cd15727
      Location:38 → 101
      FYVE_ZF21; FYVE domain found in zinc finger FYVE domain-containing protein 21 (ZF21) and similar proteins
      pfam16696
      Location:108 → 228
      ZFYVE21_C; Zinc finger FYVE domain-containing protein 21 C-terminus

    RNA

    1. XR_004937538.1 RNA Sequence

    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8VCM3.2 GenPept UniProtKB/Swiss-Prot:Q8VCM3

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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