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    ZNF527 zinc finger protein 527 [ Homo sapiens (human) ]

    Gene ID: 84503, updated on 27-Nov-2024

    Summary

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    Official Symbol
    ZNF527provided by HGNC
    Official Full Name
    zinc finger protein 527provided by HGNC
    Primary source
    HGNC:HGNC:29385
    See related
    Ensembl:ENSG00000189164 AllianceGenome:HGNC:29385
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Summary
    Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in regulation of transcription by RNA polymerase II. Predicted to be active in nucleus. [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Ubiquitous expression in thyroid (RPKM 1.6), ovary (RPKM 1.3) and 25 other tissues See more
    Orthologs
    all
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    Genomic context

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    See ZNF527 in Genome Data Viewer
    Location:
    19q13.12
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 19 NC_000019.10 (37371099..37393066)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 19 NC_060943.1 (40172613..40194581)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 19 NC_000019.9 (37862001..37883968)

    Chromosome 19 - NC_000019.10Genomic Context describing neighboring genes Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:37763986-37764523 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:37764524-37765060 Neighboring gene Putative uncharacterized protein PP6455 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:37771594-37772125 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:37772126-37772656 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:37777707-37778689 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:37787960-37788471 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 10554 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 14541 Neighboring gene H3K27ac hESC enhancer GRCh37_chr19:37809147-37810044 Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr19:37811117-37811765 Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr19:37811766-37812414 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:37824558-37825500 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:37825501-37826442 Neighboring gene zinc finger protein 875 Neighboring gene MPRA-validated peak3463 silencer Neighboring gene ATAC-STARR-seq lymphoblastoid active region 14544 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 14545 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 14546 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 10555 Neighboring gene zinc finger protein 569 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 14547 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 14548 Neighboring gene zinc finger protein 570 Neighboring gene ZNF793 antisense RNA 1 (head to head) Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:37996759-37997550 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:37997551-37998342 Neighboring gene zinc finger protein 793

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    Related articles in PubMed

    1. ZNF527 GENE rs386809049 ANALYSIS IN POPULATION OF UKRAINE. Gulkovskyi RV, et al. Tsitol Genet, 2015 Jul-Aug. PMID 26419067
    2. Prediction of the coding sequences of unidentified human genes. XX. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. Nagase T, et al. DNA Res, 2001 Apr 27. PMID 11347906
    3. Cullin 3 Exon 9 Deletion in Familial Hyperkalemic Hypertension Impairs Cullin3-Ring-E3 Ligase (CRL3) Dynamic Regulation and Cycling. Kouranti I, et al. Int J Mol Sci, 2022 May 5. PMID 35563538, Free PMC Article
    4. Complete sequencing and characterization of 21,243 full-length human cDNAs. Ota T, et al. Nat Genet, 2004 Jan. PMID 14702039
    5. Dual proteome-scale networks reveal cell-specific remodeling of the human interactome. Huttlin EL, et al. Cell, 2021 May 27. PMID 33961781, Free PMC Article

    See all (7) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Phenotypes

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    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • KIAA1829

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    zinc finger protein 527

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_032453.2 → NP_115829.1  zinc finger protein 527

      See identical proteins and their annotated locations for NP_115829.1

      Status: VALIDATED

      Source sequence(s)
      AC008806, DC341389
      Consensus CDS
      CCDS42559.1
      UniProtKB/Swiss-Prot
      B4DVL5, Q8NB42
      Related
      ENSP00000390179.2, ENST00000436120.7
      Conserved Domains (5) summary
      smart00349
      Location:14 → 74
      KRAB; krueppel associated box
      COG5048
      Location:328 → 490
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:360 → 380
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam01352
      Location:14 → 53
      KRAB; KRAB box
      pfam13465
      Location:400 → 425
      zf-H2C2_2; Zinc-finger double domain

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000019.10 Reference GRCh38.p14 Primary Assembly

      Range
      37371099..37393066
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_005259329.5 → XP_005259386.1  zinc finger protein 527 isoform X1

      See identical proteins and their annotated locations for XP_005259386.1

      UniProtKB/Swiss-Prot
      Q8NB42
      Conserved Domains (5) summary
      smart00349
      Location:14 → 54
      KRAB; krueppel associated box
      COG5048
      Location:296 → 458
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:328 → 348
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam01352
      Location:14 → 53
      KRAB; KRAB box
      pfam13465
      Location:368 → 393
      zf-H2C2_2; Zinc-finger double domain

    2. XM_005259328.6 → XP_005259385.1  zinc finger protein 527 isoform X2

      Conserved Domains (3) summary
      COG5048
      Location:296 → 458
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:328 → 348
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam13465
      Location:368 → 393
      zf-H2C2_2; Zinc-finger double domain

    3. XM_017027381.2 → XP_016882870.1  zinc finger protein 527 isoform X4

      Conserved Domains (3) summary
      COG5048
      Location:264 → 426
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:296 → 316
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam13465
      Location:336 → 361
      zf-H2C2_2; Zinc-finger double domain

    4. XM_017027380.2 → XP_016882869.1  zinc finger protein 527 isoform X3

      Conserved Domains (3) summary
      COG5048
      Location:267 → 429
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:299 → 319
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam13465
      Location:339 → 364
      zf-H2C2_2; Zinc-finger double domain

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060943.1 Alternate T2T-CHM13v2.0

      Range
      40172613..40194581
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054322359.1 → XP_054178334.1  zinc finger protein 527 isoform X1

    2. XM_054322360.1 → XP_054178335.1  zinc finger protein 527 isoform X2

    3. XM_054322362.1 → XP_054178337.1  zinc finger protein 527 isoform X4

    4. XM_054322361.1 → XP_054178336.1  zinc finger protein 527 isoform X3

    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8NB42.2 GenPept UniProtKB/Swiss-Prot:Q8NB42

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