Ppargc1a peroxisome proliferative activated receptor, gamma, coactivator 1 alpha [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Ppargc1aprovided by MGI
Official Full Name: peroxisome proliferative activated receptor, gamma, coactivator 1 alphaprovided by MGI
Primary source: MGI:MGI:1342774
See related: Ensembl:ENSMUSG00000029167 AllianceGenome:MGI:1342774
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Pgc1; PGC-1; Pgco1; Gm11133; Ppargc1; Pgc-1alpha; A830037N07Rik; PPARGC-1-alpha
Summary: This gene encodes a transcriptional coactivator that induces and coordinates gene expression regulating mitochondrial biogenesis, respiration, hepatic gluconeogenesis, thermogenic program in brown fat and muscle fiber-type switching. Mice lacking the encoded protein exhibit reduced thermogenic capacity, hyperactivity and resistance to diet-induced obesity. Mice lacking the encoded protein specifically in the heart exhibit peripartum cardiomyopathy. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Sep 2015]
Expression: Broad expression in heart adult (RPKM 4.1), frontal lobe adult (RPKM 3.9) and 22 other tissues See more
Orthologs: human all
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Genomic context

Location:: 5 C1; 5 27.02 cM

Exon count:: 20

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	5	NC_000071.7 (51611591..52273316, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	5	NC_000071.6 (51454249..52115853, complement)

Chromosome 5 - NC_000071.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Aging-associated decrease of PGC-1alpha promotes pain chronification.
Title: Aging-associated decrease of PGC-1α promotes pain chronification.
MECHANISM OF MICRORNA-218-5P IN MITOCHONDRIAL BIOGENESIS OF SEPSIS-INDUCED ACUTE KIDNEY INJURY BY THE REGULATION OF PGC-1Alpha.
Title: MECHANISM OF MICRORNA-218-5P IN MITOCHONDRIAL BIOGENESIS OF SEPSIS-INDUCED ACUTE KIDNEY INJURY BY THE REGULATION OF PGC-1Α.
Intrauterine hyperglycaemia during late gestation caused mitochondrial dysfunction in skeletal muscle of male offspring through CREB/PGC1A signaling.
Title: Intrauterine hyperglycaemia during late gestation caused mitochondrial dysfunction in skeletal muscle of male offspring through CREB/PGC1A signaling.
CREB3 mediates the transcriptional regulation of PGC-1alpha, a master regulator of energy homeostasis and mitochondrial biogenesis.
Title: CREB3 mediates the transcriptional regulation of PGC-1α, a master regulator of energy homeostasis and mitochondrial biogenesis.
Adaptive gene expression of alternative splicing variants of PGC-1alpha regulates whole-body energy metabolism.
Title: Adaptive gene expression of alternative splicing variants of PGC-1α regulates whole-body energy metabolism.
PGC-1alpha regulates endoplasmic reticulum stress in IPF-derived fibroblasts.
Title: PGC-1α regulates endoplasmic reticulum stress in IPF-derived fibroblasts.
Muscle-specific PGC-1alpha modulates mitochondrial oxidative stress in aged sarcopenia through regulating Nrf2.
Title: Muscle-specific PGC-1α modulates mitochondrial oxidative stress in aged sarcopenia through regulating Nrf2.
PGC-1alpha repression dysregulates lipid metabolism and induces lipid droplet accumulation in retinal pigment epithelium.
Title: PGC-1α repression dysregulates lipid metabolism and induces lipid droplet accumulation in retinal pigment epithelium.
PGC-1alpha activation boosts exercise-dependent cellular response in the skeletal muscle.
Title: PGC-1α activation boosts exercise-dependent cellular response in the skeletal muscle.
Clostridium butyricum upregulates GPR109A/AMPK/PGC-1alpha and ameliorates acute pancreatitis-associated intestinal barrier injury in mice.
Title: Clostridium butyricum upregulates GPR109A/AMPK/PGC-1α and ameliorates acute pancreatitis-associated intestinal barrier injury in mice.

Submit: New GeneRIF Correction See all GeneRIFs (629)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (7) 1 citation
Targeted (8) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

MARC_49176-49177:1118326844:1 (e-PCR)
- UniSTS:477493

Ppargc1a (e-PCR), detects polymorphism
- UniSTS:531399

PPARGC1A__5755 (e-PCR)
- UniSTS:463821

Ppargc1a (e-PCR), detects polymorphism
- UniSTS:479198

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables DNA binding	IDA Inferred from Direct Assay more info	PubMed
enables RNA polymerase II-specific DNA-binding transcription factor binding	IPI Inferred from Physical Interaction more info	PubMed
enables alpha-tubulin binding	ISO Inferred from Sequence Orthology more info
enables chromatin DNA binding	IDA Inferred from Direct Assay more info	PubMed
enables chromatin binding	ISO Inferred from Sequence Orthology more info
enables lncRNA binding	IPI Inferred from Physical Interaction more info	PubMed
enables nuclear estrogen receptor binding	ISO Inferred from Sequence Orthology more info
enables nuclear receptor binding	IEA Inferred from Electronic Annotation more info
enables nuclear receptor binding	ISO Inferred from Sequence Orthology more info
enables nuclear receptor coactivator activity	IBA Inferred from Biological aspect of Ancestor more info
enables nuclear receptor coactivator activity	IEA Inferred from Electronic Annotation more info
enables nuclear receptor coactivator activity	ISO Inferred from Sequence Orthology more info
enables peroxisome proliferator activated receptor binding	ISO Inferred from Sequence Orthology more info
enables promoter-specific chromatin binding	ISO Inferred from Sequence Orthology more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables sequence-specific DNA binding	ISO Inferred from Sequence Orthology more info
enables sequence-specific DNA binding	ISS Inferred from Sequence or Structural Similarity more info
enables transcription coactivator activity	IDA Inferred from Direct Assay more info	PubMed
enables transcription coactivator activity	IMP Inferred from Mutant Phenotype more info	PubMed
enables transcription coactivator activity	ISO Inferred from Sequence Orthology more info	PubMed
enables transcription coregulator activity	IDA Inferred from Direct Assay more info	PubMed
enables ubiquitin protein ligase binding	IEA Inferred from Electronic Annotation more info
enables ubiquitin protein ligase binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in adipose tissue development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in cellular response to follicle-stimulating hormone stimulus	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within cellular response to oxidative stress	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in cellular response to thyroid hormone stimulus	ISO Inferred from Sequence Orthology more info
involved_in cellular response to transforming growth factor beta stimulus	ISO Inferred from Sequence Orthology more info
involved_in circadian regulation of gene expression	IDA Inferred from Direct Assay more info	PubMed
involved_in energy homeostasis	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of energy homeostasis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in energy homeostasis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in gluconeogenesis	IDA Inferred from Direct Assay more info	PubMed
involved_in gluconeogenesis	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within mitochondrion organization	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within mitochondrion organization	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in mitochondrion organization	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of glycolytic process	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of mitochondrial fission	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within negative regulation of neuron apoptotic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of protein phosphorylation	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of smooth muscle cell migration	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of smooth muscle cell proliferation	IEA Inferred from Electronic Annotation more info
acts_upstream_of negative regulation of smooth muscle cell proliferation	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of smooth muscle cell proliferation	ISO Inferred from Sequence Orthology more info
acts_upstream_of neuron apoptotic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of DNA-binding transcription factor activity	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of DNA-binding transcription factor activity	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within positive regulation of DNA-templated transcription	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of DNA-templated transcription	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of DNA-templated transcription	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of cold-induced thermogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of fatty acid oxidation	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of gene expression	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of gene expression	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of podocyte apoptotic process	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of progesterone biosynthetic process	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of transcription by RNA polymerase II	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within positive regulation of transcription by RNA polymerase II	IGI Inferred from Genetic Interaction more info	PubMed
involved_in positive regulation of transcription by RNA polymerase II	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of transcription by RNA polymerase II	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of vascular associated smooth muscle cell proliferation	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within regulation of DNA-templated transcription	ISO Inferred from Sequence Orthology more info	PubMed
involved_in regulation of DNA-templated transcription	ISO Inferred from Sequence Orthology more info
involved_in regulation of DNA-templated transcription	ISS Inferred from Sequence or Structural Similarity more info
involved_in regulation of circadian rhythm	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within respiratory electron transport chain	IDA Inferred from Direct Assay more info	PubMed
involved_in response to activity	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within response to dietary excess	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within response to muscle activity	IDA Inferred from Direct Assay more info	PubMed
involved_in response to muscle activity	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in PML body	IEA Inferred from Electronic Annotation more info
located_in apical dendrite	ISO Inferred from Sequence Orthology more info
located_in chromatin	ISO Inferred from Sequence Orthology more info	PubMed
located_in cytosol	IEA Inferred from Electronic Annotation more info
located_in cytosol	ISO Inferred from Sequence Orthology more info
located_in cytosolic ribosome	ISO Inferred from Sequence Orthology more info
located_in euchromatin	ISO Inferred from Sequence Orthology more info
located_in neuronal cell body	ISO Inferred from Sequence Orthology more info
located_in nucleoplasm	ISO Inferred from Sequence Orthology more info
located_in nucleoplasm	TAS Traceable Author Statement more info
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	IDA Inferred from Direct Assay more info	PubMed
is_active_in nucleus	ISO Inferred from Sequence Orthology more info
located_in nucleus	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: peroxisome proliferator-activated receptor gamma coactivator 1-alpha

Names: PPAR-gamma coactivator 1-alpha

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001402987.1 → NP_001389916.1 peroxisome proliferator-activated receptor gamma coactivator 1-alpha isoform b

Status: REVIEWED

Source sequence(s)

AC111037, AC116763
NM_001402988.1 → NP_001389917.1 peroxisome proliferator-activated receptor gamma coactivator 1-alpha isoform c

Status: REVIEWED

Source sequence(s)

AC111037, AC116763, AC158149
NM_001402989.1 → NP_001389918.1 peroxisome proliferator-activated receptor gamma coactivator 1-alpha isoform d

Status: REVIEWED

Source sequence(s)

AC116763
NM_001402990.1 → NP_001389919.1 peroxisome proliferator-activated receptor gamma coactivator 1-alpha isoform e

Status: REVIEWED

Source sequence(s)

AC116763, AC163408
NM_001402991.1 → NP_001389920.1 peroxisome proliferator-activated receptor gamma coactivator 1-alpha isoform e

Status: REVIEWED

Source sequence(s)

AC116763
NM_008904.3 → NP_032930.1 peroxisome proliferator-activated receptor gamma coactivator 1-alpha isoform a

See identical proteins and their annotated locations for NP_032930.1

Status: REVIEWED

Source sequence(s)

AC116763

Consensus CDS

CCDS19282.1

UniProtKB/Swiss-Prot

L0AM20, L0AN96, L0APB0, O70343, Q3UP72

UniProtKB/TrEMBL

A0A0G2JGG3

Related

ENSMUSP00000117040.2, ENSMUST00000132734.8

Conserved Domains (1) summary

cd12623
Location:674 → 764

RRM_PPARGC1A; RNA recognition motif (RRM) found in peroxisome proliferator-activated receptor gamma coactivator 1-alpha (PGC-1alpha, or PPARGC-1-alpha) and similar proteins

RNA

NR_027710.2 RNA Sequence

Status: REVIEWED

Source sequence(s)

AC116763
NR_132764.1 RNA Sequence

Status: REVIEWED

Source sequence(s)

AC116763, BB853729, JX866948
NR_175325.1 RNA Sequence

Status: REVIEWED

Source sequence(s)

AC111037, AC116763, AC158149
NR_175326.1 RNA Sequence

Status: REVIEWED

Source sequence(s)

AC116763
NR_175327.1 RNA Sequence

Status: REVIEWED

Source sequence(s)

AC116763

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000071.7 Reference GRCm39 C57BL/6J

Range

51611591..52273316 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_006503775.2 → XP_006503838.1 peroxisome proliferator-activated receptor gamma coactivator 1-alpha isoform X2

UniProtKB/TrEMBL

A0A0G2JGG3

Conserved Domains (1) summary

cd12623
Location:670 → 760

RRM_PPARGC1A; RNA recognition motif in peroxisome proliferator-activated receptor gamma coactivator 1-alpha (PGC-1alpha, or PPARGC-1-alpha) and similar proteins
XM_036164894.1 → XP_036020787.1 peroxisome proliferator-activated receptor gamma coactivator 1-alpha isoform X6

Conserved Domains (1) summary

cd12623
Location:674 → 764

RRM_PPARGC1A; RNA recognition motif (RRM) found in peroxisome proliferator-activated receptor gamma coactivator 1-alpha (PGC-1alpha, or PPARGC-1-alpha) and similar proteins
XM_017320718.3 → XP_017176207.1 peroxisome proliferator-activated receptor gamma coactivator 1-alpha isoform X5

Conserved Domains (1) summary

cd12623
Location:549 → 639

RRM_PPARGC1A; RNA recognition motif in peroxisome proliferator-activated receptor gamma coactivator 1-alpha (PGC-1alpha, or PPARGC-1-alpha) and similar proteins
XM_030254205.2 → XP_030110065.1 peroxisome proliferator-activated receptor gamma coactivator 1-alpha isoform X5

Conserved Domains (1) summary

cd12623
Location:549 → 639

RRM_PPARGC1A; RNA recognition motif in peroxisome proliferator-activated receptor gamma coactivator 1-alpha (PGC-1alpha, or PPARGC-1-alpha) and similar proteins