Tpi1 triosephosphate isomerase 1 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Tpi1provided by MGI
Official Full Name: triosephosphate isomerase 1provided by MGI
Primary source: MGI:MGI:98797
See related: Ensembl:ENSMUSG00000023456 AllianceGenome:MGI:98797
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: TIM; Tpi; Tpi-1
Summary: Enables triose-phosphate isomerase activity. Involved in canonical glycolysis; gluconeogenesis; and glyceraldehyde-3-phosphate metabolic process. Acts upstream of or within glucose metabolic process. Is active in cytosol. Is expressed in several structures, including alimentary system; genitourinary system; nervous system; respiratory system; and sensory organ. Used to study triosephosphate isomerase deficiency. Human ortholog(s) of this gene implicated in carbohydrate metabolic disorder and triosephosphate isomerase deficiency. Orthologous to human TPI1 (triosephosphate isomerase 1). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Ubiquitous expression in placenta adult (RPKM 378.7), kidney adult (RPKM 378.5) and 28 other tissues See more
Orthologs: human all
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Genomic context

Location:: 6 F2; 6 59.17 cM

Exon count:: 7

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	6	NC_000072.7 (124787549..124791121, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	6	NC_000072.6 (124810586..124814158, complement)

Chromosome 6 - NC_000072.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

LKB1-Dependent Regulation of TPI1 Creates a Divergent Metabolic Liability between Human and Mouse Lung Adenocarcinoma.
Title: LKB1-Dependent Regulation of TPI1 Creates a Divergent Metabolic Liability between Human and Mouse Lung Adenocarcinoma.
Low catalytic activity is insufficient to induce disease pathology in triosephosphate isomerase deficiency.
Title: Low catalytic activity is insufficient to induce disease pathology in triosephosphate isomerase deficiency.
TPI interacts with Tau protein in a normal, nondisease state as well as in a neurodegenerative state.
Title: Effects of Tau on the activity of triose phosphate isomerase (TPI) in brain cells.
Triosephosphate isomerase activity-deficient mice show haemolytic anaemia in homozygous condition
Title: Triosephosphate isomerase activity-deficient mice show haemolytic anaemia in homozygous condition.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Chemically induced (ENU) (5) 1 citation
Chemically induced (other) (2) 1 citation
Endonuclease-mediated (2)
Targeted (2) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

AI461677 (e-PCR)
- UniSTS:179459

TPI1 (e-PCR)
- UniSTS:266275

AI255506 (e-PCR)
- UniSTS:165488

RH124604 (e-PCR)
- UniSTS:161426

Tpi1 (e-PCR), detects polymorphism
- UniSTS:507287

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables isomerase activity	IDA Inferred from Direct Assay more info	PubMed
enables methylglyoxal synthase activity	ISS Inferred from Sequence or Structural Similarity more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein homodimerization activity	ISO Inferred from Sequence Orthology more info
enables protein homodimerization activity	ISS Inferred from Sequence or Structural Similarity more info
enables triose-phosphate isomerase activity	IBA Inferred from Biological aspect of Ancestor more info
enables triose-phosphate isomerase activity	IDA Inferred from Direct Assay more info	PubMed
enables triose-phosphate isomerase activity	IMP Inferred from Mutant Phenotype more info	PubMed
enables triose-phosphate isomerase activity	ISO Inferred from Sequence Orthology more info
enables ubiquitin protein ligase binding	IEA Inferred from Electronic Annotation more info
enables ubiquitin protein ligase binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in canonical glycolysis	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within embryo development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in gluconeogenesis	IBA Inferred from Biological aspect of Ancestor more info
involved_in gluconeogenesis	IDA Inferred from Direct Assay more info	PubMed
involved_in gluconeogenesis	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within glucose metabolic process	IDA Inferred from Direct Assay more info	PubMed
involved_in glyceraldehyde-3-phosphate biosynthetic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in glyceraldehyde-3-phosphate biosynthetic process	ISO Inferred from Sequence Orthology more info	PubMed
involved_in glyceraldehyde-3-phosphate biosynthetic process	ISS Inferred from Sequence or Structural Similarity more info
involved_in glyceraldehyde-3-phosphate metabolic process	IDA Inferred from Direct Assay more info	PubMed
involved_in glycerol catabolic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in glycolytic process	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within glycolytic process	IC Inferred by Curator more info	PubMed
involved_in methylglyoxal biosynthetic process	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of_or_within multicellular organism development	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
is_active_in cytosol	IBA Inferred from Biological aspect of Ancestor more info
is_active_in cytosol	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: triosephosphate isomerase

Names: methylglyoxal synthase; triose-phosphate isomerase

NP_033441.3

EC 4.2.3.3

EC 5.3.1.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.