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    Cdca7l cell division cycle associated 7 like [ Mus musculus (house mouse) ]

    Gene ID: 217946, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Cdca7lprovided by MGI
    Official Full Name
    cell division cycle associated 7 likeprovided by MGI
    Primary source
    MGI:MGI:2384982
    See related
    Ensembl:ENSMUSG00000021175 AllianceGenome:MGI:2384982
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    JPO2
    Summary
    Predicted to be involved in regulation of DNA-templated transcription. Predicted to act upstream of or within positive regulation of cell population proliferation. Predicted to be located in cytosol; fibrillar center; and nucleoplasm. Predicted to be active in nucleus. Is expressed in several structures, including brain; genitourinary system; gut; respiratory system; and sensory organ. Orthologous to human CDCA7L (cell division cycle associated 7 like). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Ubiquitous expression in CNS E11.5 (RPKM 5.1), liver E14 (RPKM 4.5) and 24 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Cdca7l in Genome Data Viewer
    Location:
    12 F2; 12 63.2 cM
    Exon count:
    13
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 12 NC_000078.7 (117807209..117842441)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 12 NC_000078.6 (117843475..117878712)

    Chromosome 12 - NC_000078.7Genomic Context describing neighboring genes Neighboring gene Rap guanine nucleotide exchange factor (GEF) 5 Neighboring gene STARR-positive B cell enhancer mm9_chr12:119003289-119003590 Neighboring gene heterogeneous nuclear ribonucleoprotein A2/B1 pseudogene Neighboring gene STARR-positive B cell enhancer mm9_chr12:119058566-119058867 Neighboring gene STARR-seq mESC enhancer starr_33427 Neighboring gene 60S acidic ribosomal protein P2 pseudogene Neighboring gene dynein, axonemal, heavy chain 11 Neighboring gene STARR-seq mESC enhancer starr_33429 Neighboring gene STARR-positive B cell enhancer mm9_chr12:119539914-119540215 Neighboring gene STARR-positive B cell enhancer mm9_chr12:119540362-119540663 Neighboring gene trans-acting transcription factor 4 Neighboring gene CapStarr-seq enhancer MGSCv37_chr12:119611733-119611916 Neighboring gene STARR-seq mESC enhancer starr_33430 Neighboring gene CapStarr-seq enhancer MGSCv37_chr12:119615690-119615886 Neighboring gene predicted gene, 25577

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. E2F2 Promotes Wound Healing of Diabetic Foot Ulcer by Regulating CDCA7L Transcription. Xiao M, et al. Exp Clin Endocrinol Diabetes, 2023 Mar. PMID 36893788
    2. Arlm1 is a male-specific modifier of astrocytoma resistance on mouse Chr 12. Amlin-Van Schaick JC, et al. Neuro Oncol, 2012 Feb. PMID 22234937, Free PMC Article
    3. Monoamine oxidase A and repressor R1 are involved in apoptotic signaling pathway. Ou XM, et al. Proc Natl Acad Sci U S A, 2006 Jul 18. PMID 16829576, Free PMC Article
    4. Identification of a novel c-Myc protein interactor, JPO2, with transforming activity in medulloblastoma cells. Huang A, et al. Cancer Res, 2005 Jul 1. PMID 15994933
    5. Genes expressed in Atoh1 neuronal lineages arising from the r1/isthmus rhombic lip. Machold R, et al. Gene Expr Patterns, 2011 Jun-Jul. PMID 21440680, Free PMC Article

    See all (23) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. E2F2 Promotes Wound Healing of Diabetic Foot Ulcer by Regulating CDCA7L Transcription.
      Title: E2F2 Promotes Wound Healing of Diabetic Foot Ulcer by Regulating CDCA7L Transcription.
    2. Mouse JPO2/RAM2 (Cdca7l) interacts with cMyc.
      Title: Identification of a novel c-Myc protein interactor, JPO2, with transforming activity in medulloblastoma cells.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (1) 

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC11998

    Gene Ontology Provided by MGI

    Process Evidence Code Pubs
    acts_upstream_of_or_within positive regulation of cell population proliferation ISO
    Inferred from Sequence Orthology
    more info
    		 PubMed 
    involved_in regulation of DNA-templated transcription IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in cytosol IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in fibrillar center IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in fibrillar center ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleolus ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    cell division cycle-associated 7-like protein
    Names
    transcription factor RAM2

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001412933.1 → NP_001399862.1  cell division cycle-associated 7-like protein isoform 1

      Status: VALIDATED

      Source sequence(s)
      AC139993

    2. NM_001412934.1 → NP_001399863.1  cell division cycle-associated 7-like protein isoform 2

      Status: VALIDATED

      Source sequence(s)
      AC139993

    3. NM_001412935.1 → NP_001399864.1  cell division cycle-associated 7-like protein isoform 4

      Status: VALIDATED

      Source sequence(s)
      AC139993

    4. NM_146040.2 → NP_666152.1  cell division cycle-associated 7-like protein isoform 3

      See identical proteins and their annotated locations for NP_666152.1

      Status: VALIDATED

      Source sequence(s)
      AC139993, AK149673
      Consensus CDS
      CCDS49197.1
      UniProtKB/Swiss-Prot
      Q922M5
      Related
      ENSMUSP00000021592.10, ENSMUST00000021592.16
      Conserved Domains (1) summary
      pfam10497
      Location:333 → 431
      zf-4CXXC_R1; Zinc-finger domain of monoamine-oxidase A repressor R1

    RNA

    1. NR_182072.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AC139993

    2. NR_182073.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AC139993

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000078.7 Reference GRCm39 C57BL/6J

      Range
      117807209..117842441
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_011244100.4 → XP_011242402.3  cell division cycle-associated 7-like protein isoform X4

      Conserved Domains (1) summary
      pfam10497
      Location:363 → 416
      zf-4CXXC_R1; Zinc-finger domain of monoamine-oxidase A repressor R1
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q922M5.1 GenPept UniProtKB/Swiss-Prot:Q922M5

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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