Sugp1 SURP and G patch domain containing 1 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Sugp1provided by MGI
Official Full Name: SURP and G patch domain containing 1provided by MGI
Primary source: MGI:MGI:1917866
See related: Ensembl:ENSMUSG00000011306 AllianceGenome:MGI:1917866
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Sf4; 5730496N02Rik
Summary: Predicted to enable RNA binding activity. Predicted to be involved in RNA splicing and mRNA processing. Predicted to be part of spliceosomal complex. Predicted to be active in nucleoplasm. Is expressed in cerebral cortex ventricular layer and cortical plate. Orthologous to human SUGP1 (SURP and G-patch domain containing 1). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Ubiquitous expression in testis adult (RPKM 15.9), CNS E14 (RPKM 11.1) and 28 other tissues See more
Orthologs: human all
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Genomic context

Location:: 8 B3.3; 8 34.15 cM

Exon count:: 14

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	8	NC_000074.7 (70495435..70524997)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	8	NC_000074.6 (70042769..70072347)

Chromosome 8 - NC_000074.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Our results strongly support a role for SUGP1 as a novel regulator of cholesterol metabolism and suggest that it contributes to the relationship between rs10401969 and plasma cholesterol
Title: SUGP1 is a novel regulator of cholesterol metabolism.

Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (3)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables RNA binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in RNA splicing	IEA Inferred from Electronic Annotation more info
involved_in mRNA processing	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
is_active_in nucleoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleoplasm	IEA Inferred from Electronic Annotation more info
located_in nucleoplasm	ISO Inferred from Sequence Orthology more info
part_of spliceosomal complex	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: SURP and G-patch domain-containing protein 1

Names: splicing factor 4

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001368391.1 → NP_001355320.1 SURP and G-patch domain-containing protein 1

Status: VALIDATED

Source sequence(s)

AC167132

Consensus CDS

CCDS22356.1

UniProtKB/Swiss-Prot

Q0VAT9, Q3U0W3, Q8CH02, Q8R094
NM_027481.3 → NP_081757.1 SURP and G-patch domain-containing protein 1

See identical proteins and their annotated locations for NP_081757.1

Status: VALIDATED

Source sequence(s)

AC167132

Consensus CDS

CCDS22356.1

UniProtKB/Swiss-Prot

Q0VAT9, Q3U0W3, Q8CH02, Q8R094

Related

ENSMUSP00000011450.7, ENSMUST00000011450.8

Conserved Domains (2) summary

pfam01585
Location:561 → 605

G-patch; G-patch domain

pfam01805
Location:186 → 237

Surp; Surp module

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000074.7 Reference GRCm39 C57BL/6J

Range

70495435..70524997

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_030243755.2 → XP_030099615.1 SURP and G-patch domain-containing protein 1 isoform X1

Conserved Domains (3) summary

PRK12270
Location:335 → 458

kgd; multifunctional oxoglutarate decarboxylase/oxoglutarate dehydrogenase thiamine pyrophosphate-binding subunit/dihydrolipoyllysine-residue succinyltransferase subunit

pfam01585
Location:603 → 645

G-patch; G-patch domain

pfam01805
Location:227 → 278

Surp; Surp module
XM_036154283.1 → XP_036010176.1 SURP and G-patch domain-containing protein 1 isoform X2

Conserved Domains (3) summary

PRK12270
Location:87 → 210

kgd; multifunctional oxoglutarate decarboxylase/oxoglutarate dehydrogenase thiamine pyrophosphate-binding subunit/dihydrolipoyllysine-residue succinyltransferase subunit

pfam01585
Location:355 → 399

G-patch; G-patch domain

pfam01805
Location:55 → 106

Surp; Surp module