Homer3 homer scaffolding protein 3 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Homer3provided by MGI
Official Full Name: homer scaffolding protein 3provided by MGI
Primary source: MGI:MGI:1347359
See related: Ensembl:ENSMUSG00000003573 AllianceGenome:MGI:1347359
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Summary: Enables protein domain specific binding activity. Involved in regulation of postsynaptic neurotransmitter receptor activity. Located in basal part of cell and cytosol. Is active in glutamatergic synapse and postsynaptic density. Is expressed in several structures, including exocrine system; jaw; nervous system; sensory organ; and tongue. Orthologous to human HOMER3 (homer scaffold protein 3). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Ubiquitous expression in cerebellum adult (RPKM 62.8), ovary adult (RPKM 38.6) and 27 other tissues See more
Orthologs: human all
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Genomic context

Location:: 8 B3.3; 8 34.15 cM

Exon count:: 11

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	8	NC_000074.7 (70735529..70747011)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	8	NC_000074.6 (70282880..70294361)

Chromosome 8 - NC_000074.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

HOMER3 facilitates growth factor-mediated beta-Catenin tyrosine phosphorylation and activation to promote metastasis in triple negative breast cancer.
Title: HOMER3 facilitates growth factor-mediated β-Catenin tyrosine phosphorylation and activation to promote metastasis in triple negative breast cancer.
Distinct and Overlapping Expression Patterns of the Homer Family of Scaffolding Proteins and Their Encoding Genes in Developing Murine Cephalic Tissues.
Title: Distinct and Overlapping Expression Patterns of the Homer Family of Scaffolding Proteins and Their Encoding Genes in Developing Murine Cephalic Tissues.
Data indicate decreased bone density in homer scaffolding proteins (Homer2/3) double knockout (DKO) mice.
Title: Homer2 and Homer3 modulate RANKL-induced NFATc1 signaling in osteoclastogenesis and bone metabolism.
impaired mTORC1-Homer-3 activity underlies PC susceptibility in Spinocerebellar ataxia type 1 and presents a promising therapeutic target
Title: Impaired mTORC1-Dependent Expression of Homer-3 Influences SCA1 Pathophysiology.
Homer2 and Homer3 proteins interact specifically with amyloid precursor protein (APP) by inhibiting APP processing and reducing secretion of Abeta peptides.
Title: Homer2 and Homer3 interact with amyloid precursor protein and inhibit Abeta production.
Homer3 in Purkinje cells might function as a reversible coupler regulated by CaMKII phosphorylation and that the phosphorylation is capable of regulating the postsynaptic molecular architecture in response to synaptic activity.
Title: Phosphorylation of Homer3 by calcium/calmodulin-dependent kinase II regulates a coupling state of its target molecules in Purkinje cells.
study found that Homer2 and Homer3 are negative regulators of T cell activation; this is achieved through binding of nuclear factor of activated T cells (NFAT) and by competing with calcineurin
Title: NFAT binding and regulation of T cell activation by the cytoplasmic scaffolding Homer proteins.
Expression of Homer 3a/b is restricted to the developing cerebellum, hippocampus, and neonatal olfactory bulb, and is concentrated in the dendritic spines of Purkinje cells and their axons.
Title: Differential expression of Homer family proteins in the developing mouse brain.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (1)
Targeted (1) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables G protein-coupled glutamate receptor binding	IBA Inferred from Biological aspect of Ancestor more info
enables G protein-coupled glutamate receptor binding	IEA Inferred from Electronic Annotation more info
enables identical protein binding	IEA Inferred from Electronic Annotation more info
enables identical protein binding	ISO Inferred from Sequence Orthology more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein domain specific binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in G protein-coupled glutamate receptor signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within G protein-coupled glutamate receptor signaling pathway	TAS Traceable Author Statement more info	PubMed
involved_in negative regulation of calcineurin-NFAT signaling cascade	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of calcineurin-NFAT signaling cascade	ISS Inferred from Sequence or Structural Similarity more info
involved_in negative regulation of interleukin-2 production	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of interleukin-2 production	ISS Inferred from Sequence or Structural Similarity more info
involved_in regulation of postsynaptic neurotransmitter receptor activity	IDA Inferred from Direct Assay more info	PubMed
involved_in regulation of postsynaptic neurotransmitter receptor activity	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of store-operated calcium entry	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
located_in basal part of cell	IDA Inferred from Direct Assay more info	PubMed
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in cytosol	IDA Inferred from Direct Assay more info	PubMed
is_active_in dendrite	IBA Inferred from Biological aspect of Ancestor more info
is_active_in glutamatergic synapse	IDA Inferred from Direct Assay more info	PubMed
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
is_active_in postsynaptic density	IBA Inferred from Biological aspect of Ancestor more info
is_active_in postsynaptic density	IDA Inferred from Direct Assay more info	PubMed
located_in postsynaptic density	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: homer protein homolog 3

Names: homer homolog 3; homer, neuronal immediate early gene, 3; homer-3

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001146153.1 → NP_001139625.1 homer protein homolog 3 isoform 1

See identical proteins and their annotated locations for NP_001139625.1

Status: VALIDATED

Description

Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).

Source sequence(s)

AC158553, BU054773, CX208892

Consensus CDS

CCDS52569.1

UniProtKB/Swiss-Prot

Q99JP6

Related

ENSMUSP00000105751.3, ENSMUST00000110124.9

Conserved Domains (2) summary

cd01206
Location:6 → 114

EVH1_Homer_Vesl; Homer/Vesl family proteins EVH1 domain

TIGR02168
Location:166 → 354

SMC_prok_B; chromosome segregation protein SMC, common bacterial type
NM_011984.2 → NP_036114.2 homer protein homolog 3 isoform 2

See identical proteins and their annotated locations for NP_036114.2

Status: VALIDATED

Description

Transcript Variant: This variant (2) uses an alternate in-frame splice site in the 3' coding region compared to variant 1. This results in a shorter protein (isoform 2) compared to isoform 1.

Source sequence(s)

AC158553, BU054773, CX208892

Consensus CDS

CCDS22363.1

UniProtKB/Swiss-Prot

D3Z6N9, Q99JP6, Q9Z215

Related

ENSMUSP00000117033.2, ENSMUST00000140212.8

Conserved Domains (2) summary

cd01206
Location:6 → 114

EVH1_Homer_Vesl; Homer/Vesl family proteins EVH1 domain

TIGR02168
Location:167 → 353

SMC_prok_B; chromosome segregation protein SMC, common bacterial type

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000074.7 Reference GRCm39 C57BL/6J

Range

70735529..70747011

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_006509679.3 → XP_006509742.1 homer protein homolog 3 isoform X2

See identical proteins and their annotated locations for XP_006509742.1

Conserved Domains (2) summary

cd01206
Location:6 → 114

EVH1_Homer_Vesl; Homer/Vesl family proteins EVH1 domain

TIGR02168
Location:166 → 346

SMC_prok_B; chromosome segregation protein SMC, common bacterial type
XM_036154063.1 → XP_036009956.1 homer protein homolog 3 isoform X7

Conserved Domains (2) summary

cd01206
Location:6 → 114

EVH1_Homer_Vesl; Homer/Vesl family proteins EVH1 domain

TIGR02168
Location:197 → 329

SMC_prok_B; chromosome segregation protein SMC, common bacterial type
XM_030243589.2 → XP_030099449.1 homer protein homolog 3 isoform X9

Conserved Domains (1) summary

cd01206
Location:6 → 114

EVH1_Homer_Vesl; Homer/Vesl family proteins EVH1 domain
XM_006509681.4 → XP_006509744.1 homer protein homolog 3 isoform X10

Conserved Domains (2) summary

TIGR02168
Location:166 → 346

SMC_prok_B; chromosome segregation protein SMC, common bacterial type

cl17171
Location:56 → 114

PH-like; Pleckstrin homology-like domain
XM_030243588.2 → XP_030099448.1 homer protein homolog 3 isoform X5

Conserved Domains (2) summary

TIGR02168
Location:166 → 354

SMC_prok_B; chromosome segregation protein SMC, common bacterial type

cl17171
Location:56 → 114

PH-like; Pleckstrin homology-like domain
XM_030243587.1 → XP_030099447.1 homer protein homolog 3 isoform X4

Conserved Domains (2) summary

cd01206
Location:6 → 114

EVH1_Homer_Vesl; Homer/Vesl family proteins EVH1 domain

TIGR02168
Location:166 → 354

SMC_prok_B; chromosome segregation protein SMC, common bacterial type
XM_036154064.1 → XP_036009957.1 homer protein homolog 3 isoform X8

Conserved Domains (1) summary

cl17171
Location:58 → 116

PH-like; Pleckstrin homology-like domain
XM_036154060.1 → XP_036009953.1 homer protein homolog 3 isoform X1

Conserved Domains (2) summary

COG1196
Location:153 → 349

Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]

cl17171
Location:58 → 116

PH-like; Pleckstrin homology-like domain
XM_036154062.1 → XP_036009955.1 homer protein homolog 3 isoform X6

Conserved Domains (2) summary

TIGR02168
Location:199 → 331

SMC_prok_B; chromosome segregation protein SMC, common bacterial type

cl17171
Location:58 → 116

PH-like; Pleckstrin homology-like domain
XM_006509680.4 → XP_006509743.1 homer protein homolog 3 isoform X2

See identical proteins and their annotated locations for XP_006509743.1

Conserved Domains (2) summary

cd01206
Location:6 → 114

EVH1_Homer_Vesl; Homer/Vesl family proteins EVH1 domain

TIGR02168
Location:166 → 346

SMC_prok_B; chromosome segregation protein SMC, common bacterial type
XM_036154061.1 → XP_036009954.1 homer protein homolog 3 isoform X3

Conserved Domains (2) summary

TIGR02168
Location:168 → 341

SMC_prok_B; chromosome segregation protein SMC, common bacterial type

cl17171
Location:58 → 116

PH-like; Pleckstrin homology-like domain