Cpa4 carboxypeptidase A4 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Cpa4provided by MGI
Official Full Name: carboxypeptidase A4provided by MGI
Primary source: MGI:MGI:1919041
See related: Ensembl:ENSMUSG00000039070 AllianceGenome:MGI:1919041
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: 1110019K20Rik
Summary: This gene encodes a member of the carboxypeptidase A family of zinc metalloproteases that could be involved in the histone hyperacetylation pathway. The encoded preproprotein undergoes proteolytic processing that removes the N-terminal activation peptide to generate a functional enzyme. This gene is located in a cluster of carboxypeptidase genes on chromosome 6. [provided by RefSeq, Jul 2016]
Expression: Biased expression in stomach adult (RPKM 3.3), limb E14.5 (RPKM 1.8) and 6 other tissues See more
Orthologs: human all
NEW: Try the new Gene table
Try the new Transcript table

Genomic context

Location:: 6 A3.3; 6 12.52 cM

Exon count:: 12

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	6	NC_000072.7 (30568368..30592417)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	6	NC_000072.6 (30568369..30592418)

Chromosome 6 - NC_000072.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

Go to the top of the page Help

See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

Go to the top of the page Help

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Carboxypeptidase A4 promotes cardiomyocyte hypertrophy through activating PI3K-AKT-mTOR signaling.
Title: Carboxypeptidase A4 promotes cardiomyocyte hypertrophy through activating PI3K-AKT-mTOR signaling.
CPA4 functions in neuropeptide processing and regulation in the extracellular environment
Title: Characterization of the substrate specificity of human carboxypeptidase A4 and implications for a role in extracellular peptide processing.

Submit: New GeneRIF Correction

Variation

Go to the top of the page Help

Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (4)
Targeted (1) 1 citation

General gene information

Go to the top of the page Help

Markers

Cpa4 (e-PCR), detects polymorphism
- UniSTS:527293

AV009555 (e-PCR)
- UniSTS:164319

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables metallocarboxypeptidase activity	IBA Inferred from Biological aspect of Ancestor more info
enables metallocarboxypeptidase activity	ISO Inferred from Sequence Orthology more info
enables metallocarboxypeptidase activity	ISS Inferred from Sequence or Structural Similarity more info
enables zinc ion binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in hormone catabolic process	ISO Inferred from Sequence Orthology more info
involved_in hormone catabolic process	ISS Inferred from Sequence or Structural Similarity more info
involved_in peptide catabolic process	ISO Inferred from Sequence Orthology more info
involved_in peptide catabolic process	ISS Inferred from Sequence or Structural Similarity more info
involved_in proteolysis	IBA Inferred from Biological aspect of Ancestor more info
involved_in proteolysis	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
is_active_in extracellular space	IBA Inferred from Biological aspect of Ancestor more info
located_in extracellular space	ISO Inferred from Sequence Orthology more info
located_in extracellular space	ISS Inferred from Sequence or Structural Similarity more info

General protein information

Go to the top of the page Help

Preferred Names: carboxypeptidase A4

NP_082202.1

EC 3.4.17.15

XP_017177239.1

EC 3.4.17.15

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_027926.3 → NP_082202.1 carboxypeptidase A4 preproprotein

See identical proteins and their annotated locations for NP_082202.1

Status: REVIEWED

Source sequence(s)

AC155656, AK003823, AK030705

Consensus CDS

CCDS19975.1

UniProtKB/Swiss-Prot

Q6P8K8, Q8BMK6, Q9CTE6

Related

ENSMUSP00000048558.6, ENSMUST00000049251.6

Conserved Domains (2) summary

pfam02244
Location:28 → 100

Propep_M14; Carboxypeptidase activation peptide

cl11393
Location:117 → 418

Peptidase_M14_like; M14 family of metallocarboxypeptidases and related proteins

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000072.7 Reference GRCm39 C57BL/6J

Range

30568368..30592417

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_017321750.1 → XP_017177239.1 carboxypeptidase A4 isoform X1

Conserved Domains (2) summary

cd03870
Location:166 → 467

M14_CPA; Peptidase M14 carboxypeptidase subfamily A/B-like; Carboxypeptidase A subgroup

pfam02244
Location:81 → 150

Propep_M14; Carboxypeptidase activation peptide