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    Fscn3 fascin actin-bundling protein 3 [ Mus musculus (house mouse) ]

    Gene ID: 56223, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Fscn3provided by MGI
    Official Full Name
    fascin actin-bundling protein 3provided by MGI
    Primary source
    MGI:MGI:1890386
    See related
    Ensembl:ENSMUSG00000029707 AllianceGenome:MGI:1890386
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Summary
    Predicted to enable actin filament binding activity. Predicted to be involved in actin filament bundle assembly; cell migration; and establishment or maintenance of cell polarity. Predicted to act upstream of or within spermatid development. Located in cytoplasm. Is expressed in testis. Orthologous to human FSCN3 (fascin actin-bundling protein 3). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Restricted expression toward testis adult (RPKM 130.6) See more
    Orthologs
    human all
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    Genomic context

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    See Fscn3 in Genome Data Viewer
    Location:
    6 A3.3; 6 11.99 cM
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 6 NC_000072.7 (28427888..28438621)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 6 NC_000072.6 (28427870..28438622)

    Chromosome 6 - NC_000072.7Genomic Context describing neighboring genes Neighboring gene zinc finger protein 800 Neighboring gene STARR-seq mESC enhancer starr_15409 Neighboring gene kelch domain containing pseudogene Neighboring gene STARR-positive B cell enhancer mm9_chr6:28371614-28371915 Neighboring gene Pax4 5' regulatory region Neighboring gene CapStarr-seq enhancer MGSCv37_chr6:28430124-28430311 Neighboring gene golgi coiled coil 1 Neighboring gene ARF GTPase 5 Neighboring gene paired box 4 Neighboring gene staphylococcal nuclease and tudor domain containing 1 Neighboring gene STARR-seq mESC enhancer starr_15418 Neighboring gene leucine rich repeat containing 4

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Testis-specific fascin component FSCN3 is dispensable for mouse spermatogenesis and fertility. Ali H, et al. Mol Biol Rep, 2022 Jul. PMID 35449315
    2. Fascin1 is dispensable for mouse development but is favorable for neonatal survival. Yamakita Y, et al. Cell Motil Cytoskeleton, 2009 Aug. PMID 19343791, Free PMC Article
    3. Testis fascin (FSCN3): a novel paralog of the actin-bundling protein fascin expressed specifically in the elongate spermatid head. Tubb B, et al. Exp Cell Res, 2002 Apr 15. PMID 11925108
    4. Identification of candidate alkylator-induced cancer susceptibility genes by whole genome scanning in mice. Fenske TS, et al. Cancer Res, 2006 May 15. PMID 16707424
    5. A high-resolution anatomical atlas of the transcriptome in the mouse embryo. Diez-Roux G, et al. PLoS Biol, 2011 Jan 18. PMID 21267068, Free PMC Article

    See all (7) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Testis-specific fascin component FSCN3 is dispensable for mouse spermatogenesis and fertility.
      Title: Testis-specific fascin component FSCN3 is dispensable for mouse spermatogenesis and fertility.
    2. This is a novel, spermatid-specific murine paralog of the actin-binding protein fascin FSCN1. Its expression is restricted to the elongated spermatid head.
      Title: Testis fascin (FSCN3): a novel paralog of the actin-bundling protein fascin expressed specifically in the elongate spermatid head.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables actin binding ISA
    Inferred from Sequence Alignment
    more info
    		 PubMed 
    enables actin binding ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables actin filament binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables actin filament binding ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables protein-macromolecule adaptor activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in actin cytoskeleton organization ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in actin filament bundle assembly IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in actin filament organization IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in cell migration IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in establishment or maintenance of cell polarity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within spermatid development TAS
    Traceable Author Statement
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in actin cytoskeleton IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in actin cytoskeleton ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    is_active_in cell projection membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in filopodium IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in growth cone IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in lamellipodium IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in microvillus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in ruffle IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    fascin-3
    Names
    fascin (testis)
    fascin homolog 3, actin-bundling protein, testicular
    testis fascin

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001411255.1 → NP_001398184.1  fascin-3 isoform 2

      Status: VALIDATED

      Source sequence(s)
      AC068608

    2. NM_019569.3 → NP_062515.2  fascin-3 isoform 1

      See identical proteins and their annotated locations for NP_062515.2

      Status: VALIDATED

      Source sequence(s)
      AC068608
      Consensus CDS
      CCDS39446.1
      UniProtKB/Swiss-Prot
      Q80YU6, Q9QXW4
      Related
      ENSMUSP00000031719.7, ENSMUST00000031719.7
      Conserved Domains (2) summary
      cd00257
      Location:263 → 381
      Fascin; Fascin-like domain; members include actin-bundling/crosslinking proteins facsin, histoactophilin and singed; identified in sea urchin, Drosophila, Xenopus, rodents, and humans; The fascin-like domain adopts a beta-trefoil topology and contains an ...
      pfam06268
      Location:24 → 138
      Fascin; Fascin domain

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000072.7 Reference GRCm39 C57BL/6J

      Range
      28427888..28438621
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9QXW4.2 GenPept UniProtKB/Swiss-Prot:Q9QXW4

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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