Ifnk interferon kappa [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Ifnkprovided by MGI
Official Full Name: interferon kappaprovided by MGI
Primary source: MGI:MGI:2683287
See related: Ensembl:ENSMUSG00000042993 AllianceGenome:MGI:2683287
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: If1fa
Summary: Predicted to enable cytokine activity and type I interferon receptor binding activity. Predicted to be involved in several processes, including lymphocyte activation involved in immune response; response to exogenous dsRNA; and type I interferon-mediated signaling pathway. Predicted to be active in extracellular space. Is expressed in alimentary system; brain; genitourinary system; and skin. Orthologous to human IFNK (interferon kappa). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Low expression observed in reference dataset See more
Orthologs: human all
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Genomic context

Location:: 4 A5; 4 17.08 cM

Exon count:: 2

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	4	NC_000070.7 (35152055..35154019)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	4	NC_000070.6 (35152055..35154019)

Chromosome 4 - NC_000070.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

IFN-kappa Is a Rheostat for Development of Psoriasiform Inflammation.
Title: IFN-κ Is a Rheostat for Development of Psoriasiform Inflammation.
Mouse IFN-kappa is expressed at low levels in peritoneal macrophages, its expression up-regulated by double-stranded RNA and IFN-gamma; transgenic mice overexpressing murine IFN-kappa in the pancreatic islets develop overt diabetes with hyperglycemia.
Title: Expression of a novel murine type I IFN in the pancreatic islets induces diabetes in mice.

Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (3)
Targeted (3) 1 citation

General gene information

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Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables cytokine activity	IBA Inferred from Biological aspect of Ancestor more info
enables cytokine activity	IEA Inferred from Electronic Annotation more info
enables cytokine receptor binding	IEA Inferred from Electronic Annotation more info
enables type I interferon receptor binding	IBA Inferred from Biological aspect of Ancestor more info
enables type I interferon receptor binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in B cell activation involved in immune response	IBA Inferred from Biological aspect of Ancestor more info
involved_in T cell activation involved in immune response	IBA Inferred from Biological aspect of Ancestor more info
involved_in adaptive immune response	IBA Inferred from Biological aspect of Ancestor more info
involved_in cytokine-mediated signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in defense response to virus	IEA Inferred from Electronic Annotation more info
involved_in humoral immune response	IBA Inferred from Biological aspect of Ancestor more info
involved_in natural killer cell activation involved in immune response	IBA Inferred from Biological aspect of Ancestor more info
involved_in regulation of DNA-templated transcription	ISO Inferred from Sequence Orthology more info
involved_in response to exogenous dsRNA	IBA Inferred from Biological aspect of Ancestor more info
involved_in signal transduction	IEA Inferred from Electronic Annotation more info
involved_in type I interferon-mediated signaling pathway	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
is_active_in extracellular space	IBA Inferred from Biological aspect of Ancestor more info
located_in extracellular space	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: interferon kappa

Names: IFN-kappa; interferon 1fa

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.