Senp1 SUMO1/sentrin specific peptidase 1 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Senp1provided by MGI
Official Full Name: SUMO1/sentrin specific peptidase 1provided by MGI
Primary source: MGI:MGI:2445054
See related: Ensembl:ENSMUSG00000033075 AllianceGenome:MGI:2445054
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: suPr-2; D15Ertd528e; 2310046A20Rik; E330036L07Rik
Summary: Enables deSUMOylase activity. Involved in protein desumoylation. Acts upstream of or within negative regulation of proteasomal ubiquitin-dependent protein catabolic process and regulation of definitive erythrocyte differentiation. Is active in postsynaptic cytosol and presynaptic cytosol. Is expressed in embryo and heart. Used to study type 1 diabetes mellitus. Orthologous to human SENP1 (SUMO specific peptidase 1). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Ubiquitous expression in testis adult (RPKM 9.4), thymus adult (RPKM 9.2) and 28 other tissues See more
Orthologs: human all
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Genomic context

Location:: 15 F1; 15 54.04 cM

Exon count:: 22

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	15	NC_000081.7 (97936625..97991625, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	15	NC_000081.6 (98038744..98093569, complement)

Chromosome 15 - NC_000081.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

SENP1-Mediated HSP90ab1 DeSUMOylation in Cardiomyocytes Prevents Myocardial Fibrosis by Paracrine Signaling.
Title: SENP1-Mediated HSP90ab1 DeSUMOylation in Cardiomyocytes Prevents Myocardial Fibrosis by Paracrine Signaling.
LncRNA MSC-AS1 regulates SNIP1 SUMOylation-mediated EMT by binding to SENP1 to promote intestinal fibrosis in Crohn's disease.
Title: LncRNA MSC-AS1 regulates SNIP1 SUMOylation-mediated EMT by binding to SENP1 to promote intestinal fibrosis in Crohn's disease.
SENP1 regulates intermittent hypoxia-induced microglia mediated inflammation and cognitive dysfunction via wnt/beta-catenin pathway.
Title: SENP1 regulates intermittent hypoxia-induced microglia mediated inflammation and cognitive dysfunction via wnt/β-catenin pathway.
SENP1 attenuates hypoxia-reoxygenation injury in liver sinusoid endothelial cells by relying on the HIF-1alpha signaling pathway.
Title: SENP1 attenuates hypoxia‑reoxygenation injury in liver sinusoid endothelial cells by relying on the HIF‑1α signaling pathway.
A role and mechanism for redox sensing by SENP1 in beta-cell responses to high fat feeding.
Title: A role and mechanism for redox sensing by SENP1 in β-cell responses to high fat feeding.
Aberrant SUMO2/3 modification of RUNX1 upon SENP1 inhibition is linked to the development of diabetic retinopathy in mice.
Title: Aberrant SUMO2/3 modification of RUNX1 upon SENP1 inhibition is linked to the development of diabetic retinopathy in mice.
FSTL1 promotes alveolar epithelial cell aging and worsens pulmonary fibrosis by affecting SENP1-mediated DeSUMOylation.
Title: FSTL1 promotes alveolar epithelial cell aging and worsens pulmonary fibrosis by affecting SENP1-mediated DeSUMOylation.
SENP1 modulates chronic intermittent hypoxia-induced inflammation of microglia and neuronal injury by inhibiting TOM1 pathway.
Title: SENP1 modulates chronic intermittent hypoxia-induced inflammation of microglia and neuronal injury by inhibiting TOM1 pathway.
Transcription factor YY1 mediates self-renewal of glioblastoma stem cells through regulation of the SENP1/METTL3/MYC axis.
Title: Transcription factor YY1 mediates self-renewal of glioblastoma stem cells through regulation of the SENP1/METTL3/MYC axis.
Leptin accelerates BMSC transformation into vertebral epiphyseal plate chondrocytes by activating SENP1-mediated deSUMOylation of SIRT3.
Title: Leptin accelerates BMSC transformation into vertebral epiphyseal plate chondrocytes by activating SENP1-mediated deSUMOylation of SIRT3.

Submit: New GeneRIF Correction See all GeneRIFs (43)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (6)
Gene trapped (2) 1 citation
Targeted (3) 1 citation
Transgenic (1) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

D10Mit157.2 (e-PCR), detects polymorphism
- UniSTS:126061

Pfkm (e-PCR), detects polymorphism
- UniSTS:463020

Pfkm (e-PCR), detects polymorphism
- UniSTS:463021

Pfkm (e-PCR), detects polymorphism
- UniSTS:463022

Pfkm (e-PCR), detects polymorphism
- UniSTS:463023

NoName (e-PCR)
- UniSTS:234482

AU022310 (e-PCR)
- UniSTS:167166

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables SUMO-specific endopeptidase activity	IMP Inferred from Mutant Phenotype more info	PubMed
enables SUMO-specific endopeptidase activity	ISO Inferred from Sequence Orthology more info
enables SUMO-specific endopeptidase activity	ISS Inferred from Sequence or Structural Similarity more info
enables deSUMOylase activity	IBA Inferred from Biological aspect of Ancestor more info
enables deSUMOylase activity	IDA Inferred from Direct Assay more info	PubMed
enables deSUMOylase activity	IMP Inferred from Mutant Phenotype more info	PubMed
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in apoptotic signaling pathway	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within negative regulation of proteasomal ubiquitin-dependent protein catabolic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of cysteine-type endopeptidase activity	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within positive regulation of transcription by RNA polymerase II	ISO Inferred from Sequence Orthology more info
acts_upstream_of proteasome-mediated ubiquitin-dependent protein catabolic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in protein desumoylation	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within protein desumoylation	IDA Inferred from Direct Assay more info	PubMed
involved_in protein desumoylation	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within protein desumoylation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in protein desumoylation	ISO Inferred from Sequence Orthology more info
involved_in protein sumoylation	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within regulation of definitive erythrocyte differentiation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of mRNA stability	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in focal adhesion	ISO Inferred from Sequence Orthology more info
located_in nuclear membrane	ISO Inferred from Sequence Orthology more info
located_in nucleoplasm	ISO Inferred from Sequence Orthology more info
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	IEA Inferred from Electronic Annotation more info
is_active_in postsynaptic cytosol	IDA Inferred from Direct Assay more info	PubMed
is_active_in presynaptic cytosol	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: sentrin-specific protease 1

Names: SUMO-1 protease 2; SUMO1/sentrin specific protease 1; sentrin/SUMO-specific protease SENP1

NP_001366502.1

EC 3.4.22.68

NP_659100.1

EC 3.4.22.68

XP_006520943.1

EC 3.4.22.68

XP_006520945.1

EC 3.4.22.68

XP_006520946.1

EC 3.4.22.68

XP_006520947.1

EC 3.4.22.68

XP_030104385.1

EC 3.4.22.68

XP_030104386.1

EC 3.4.22.68

XP_036015277.1

EC 3.4.22.68

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001379573.1 → NP_001366502.1 sentrin-specific protease 1 isoform 1

Status: VALIDATED

Source sequence(s)

AC113444

Conserved Domains (2) summary

PRK04863
Location:381 → 475

mukB; chromosome partition protein MukB

cl23802
Location:448 → 670

Peptidase_C48; Ulp1 protease family, C-terminal catalytic domain
NM_144851.5 → NP_659100.1 sentrin-specific protease 1 isoform 2

See identical proteins and their annotated locations for NP_659100.1

Status: VALIDATED

Source sequence(s)

AK009838, AK028565, AK054521, AW490919, BF453574, CX203962

Consensus CDS

CCDS49717.1

UniProtKB/Swiss-Prot

P59110, Q8BTV5, Q8BZF1

Related

ENSMUSP00000046598.9, ENSMUST00000044189.16

Conserved Domains (1) summary

cl23802
Location:416 → 638

Peptidase_C48; Ulp1 protease family, C-terminal catalytic domain

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000081.7 Reference GRCm39 C57BL/6J

Range

97936625..97991625 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_006520882.5 → XP_006520945.1 sentrin-specific protease 1 isoform X2

UniProtKB/TrEMBL

M0QWX4

Related

ENSMUSP00000138056.2, ENSMUST00000180657.2

Conserved Domains (2) summary

PRK04863
Location:375 → 469

mukB; chromosome partition protein MukB

cl23802
Location:442 → 664

Peptidase_C48; Ulp1 protease family, C-terminal catalytic domain
XM_006520884.5 → XP_006520947.1 sentrin-specific protease 1 isoform X4

Conserved Domains (1) summary

COG5160
Location:259 → 498

ULP1; Protease, Ulp1 family [Posttranslational modification, protein turnover, chaperones]
XM_006520883.3 → XP_006520946.1 sentrin-specific protease 1 isoform X3

Conserved Domains (2) summary

COG5160
Location:285 → 524

ULP1; Protease, Ulp1 family [Posttranslational modification, protein turnover, chaperones]

PRK04863
Location:233 → 327

mukB; chromosome partition protein MukB
XM_006520880.3 → XP_006520943.1 sentrin-specific protease 1 isoform X1

Conserved Domains (2) summary

PRK04863
Location:407 → 501

mukB; chromosome partition protein MukB

cl23802
Location:474 → 696

Peptidase_C48; Ulp1 protease family, C-terminal catalytic domain
XM_030248526.1 → XP_030104386.1 sentrin-specific protease 1 isoform X4

Conserved Domains (1) summary

COG5160
Location:259 → 498

ULP1; Protease, Ulp1 family [Posttranslational modification, protein turnover, chaperones]
XM_030248525.1 → XP_030104385.1 sentrin-specific protease 1 isoform X3

Conserved Domains (2) summary

COG5160
Location:285 → 524

ULP1; Protease, Ulp1 family [Posttranslational modification, protein turnover, chaperones]

PRK04863
Location:233 → 327

mukB; chromosome partition protein MukB
XM_036159384.1 → XP_036015277.1 sentrin-specific protease 1 isoform X4

Conserved Domains (1) summary

COG5160
Location:259 → 498

ULP1; Protease, Ulp1 family [Posttranslational modification, protein turnover, chaperones]