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    Igfn1 immunoglobulin-like and fibronectin type III domain containing 1 [ Mus musculus (house mouse) ]

    Gene ID: 226438, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Igfn1provided by MGI
    Official Full Name
    immunoglobulin-like and fibronectin type III domain containing 1provided by MGI
    Primary source
    MGI:MGI:3045352
    See related
    Ensembl:ENSMUSG00000051985 AllianceGenome:MGI:3045352
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    9830123M21Rik
    Summary
    Located in Z disc and nucleus. Is expressed in brain. Orthologous to human IGFN1 (immunoglobulin like and fibronectin type III domain containing 1). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in cortex adult (RPKM 2.9) and frontal lobe adult (RPKM 1.4) See more
    Orthologs
    human all
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    Genomic context

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    See Igfn1 in Genome Data Viewer
    Location:
    1 E4; 1 59.44 cM
    Exon count:
    31
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 1 NC_000067.7 (135880943..135968663, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 1 NC_000067.6 (135953205..136040925, complement)

    Chromosome 1 - NC_000067.7Genomic Context describing neighboring genes Neighboring gene troponin T2, cardiac Neighboring gene STARR-seq mESC enhancer starr_02397 Neighboring gene plakophilin 1 Neighboring gene STARR-seq mESC enhancer starr_02398 Neighboring gene STARR-seq mESC enhancer starr_02399 Neighboring gene STARR-positive B cell enhancer ABC_E10039 Neighboring gene STARR-positive B cell enhancer ABC_E4348 Neighboring gene transmembrane protein 9 Neighboring gene calcium channel, voltage-dependent, L type, alpha 1S subunit Neighboring gene achaete-scute family bHLH transcription factor 5 Neighboring gene STARR-seq mESC enhancer starr_02400

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. IGFN1_v1 is required for myoblast fusion and differentiation. Li X, et al. PLoS One, 2017. PMID 28665998, Free PMC Article
    2. Large differences in collateral blood vessel abundance among individuals arise from multiple genetic variants. Faber JE, et al. J Cereb Blood Flow Metab, 2023 Nov. PMID 37572089, Free PMC Article
    3. Identification of a Z-band associated protein complex involving KY, FLNC and IGFN1. Baker J, et al. Exp Cell Res, 2010 Jul 1. PMID 20206623
    4. A high-resolution spatiotemporal atlas of gene expression of the developing mouse brain. Thompson CL, et al. Neuron, 2014 Jul 16. PMID 24952961, Free PMC Article
    5. BraInMap Elucidates the Macromolecular Connectivity Landscape of Mammalian Brain. Pourhaghighi R, et al. Cell Syst, 2020 Apr 22. PMID 32325033, Free PMC Article

    See all (16) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (3) 

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC129490, MGC129491

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables molecular_function ND
    No biological Data available
    more info
    		  
    Component Evidence Code Pubs
    located_in Z disc IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    immunoglobulin-like and fibronectin type III domain-containing protein 1
    Names
    eEF1A2 binding protein
    immunoglobulin-like and fibronectin type 3 domain containing 1 protein

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_177642.3 → NP_808310.2  immunoglobulin-like and fibronectin type III domain-containing protein 1

      See identical proteins and their annotated locations for NP_808310.2

      Status: VALIDATED

      Source sequence(s)
      AC108813, GU290042
      Consensus CDS
      CCDS48379.1
      UniProtKB/Swiss-Prot
      Q3KNY0, Q8BZ74
      Related
      ENSMUSP00000129680.3, ENSMUST00000166193.9
      Conserved Domains (5) summary
      cd00096
      Location:2773 → 2841
      Ig; Immunoglobulin domain
      smart00410
      Location:2154 → 2238
      IG_like; Immunoglobulin like
      cd00063
      Location:2342 → 2434
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
      pfam07679
      Location:2755 → 2844
      I-set; Immunoglobulin I-set domain
      cl11960
      Location:2563 → 2635
      Ig; Immunoglobulin domain

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000067.7 Reference GRCm39 C57BL/6J

      Range
      135880943..135968663 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006529442.3 → XP_006529505.1  immunoglobulin-like and fibronectin type III domain-containing protein 1 isoform X5

      UniProtKB/TrEMBL
      F6QKE4
      Related
      ENSMUSP00000119230.3, ENSMUST00000124134.3
      Conserved Domains (6) summary
      cd00063
      Location:690 → 782
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
      cd00096
      Location:1121 → 1189
      Ig; Immunoglobulin domain
      pfam04147
      Location:130 → 183
      Nop14; Nop14-like family
      pfam07679
      Location:30 → 121
      I-set; Immunoglobulin I-set domain
      pfam18362
      Location:168 → 201
      THB; Tri-helix bundle domain
      cl11960
      Location:403 → 486
      Ig; Immunoglobulin domain

    2. XM_017319937.1 → XP_017175426.1  immunoglobulin-like and fibronectin type III domain-containing protein 1 isoform X1

      Conserved Domains (5) summary
      cd00063
      Location:2185 → 2277
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
      cd00096
      Location:2616 → 2684
      Ig; Immunoglobulin domain
      pfam07679
      Location:30 → 121
      I-set; Immunoglobulin I-set domain
      pfam18362
      Location:168 → 201
      THB; Tri-helix bundle domain
      cl11960
      Location:1898 → 1981
      Ig; Immunoglobulin domain

    3. XM_017319947.2 → XP_017175436.1  immunoglobulin-like and fibronectin type III domain-containing protein 1 isoform X6

      UniProtKB/Swiss-Prot
      Q3KNY0
      Conserved Domains (3) summary
      cd00063
      Location:138 → 230
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
      cd00096
      Location:569 → 637
      Ig; Immunoglobulin domain
      cl11960
      Location:360 → 422
      Ig; Immunoglobulin domain

    4. XM_017319938.2 → XP_017175427.1  immunoglobulin-like and fibronectin type III domain-containing protein 1 isoform X1

      Conserved Domains (5) summary
      cd00063
      Location:2185 → 2277
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
      cd00096
      Location:2616 → 2684
      Ig; Immunoglobulin domain
      pfam07679
      Location:30 → 121
      I-set; Immunoglobulin I-set domain
      pfam18362
      Location:168 → 201
      THB; Tri-helix bundle domain
      cl11960
      Location:1898 → 1981
      Ig; Immunoglobulin domain

    5. XM_017319940.2 → XP_017175429.1  immunoglobulin-like and fibronectin type III domain-containing protein 1 isoform X1

      Conserved Domains (5) summary
      cd00063
      Location:2185 → 2277
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
      cd00096
      Location:2616 → 2684
      Ig; Immunoglobulin domain
      pfam07679
      Location:30 → 121
      I-set; Immunoglobulin I-set domain
      pfam18362
      Location:168 → 201
      THB; Tri-helix bundle domain
      cl11960
      Location:1898 → 1981
      Ig; Immunoglobulin domain

    6. XM_036163957.1 → XP_036019850.1  immunoglobulin-like and fibronectin type III domain-containing protein 1 isoform X3

      Conserved Domains (4) summary
      cd00063
      Location:2041 → 2133
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
      pfam18362
      Location:24 → 57
      THB; Tri-helix bundle domain
      cd00096
      Location:2454 → 2456
      Ig; Ig strand A [structural motif]
      cl11960
      Location:2454 → 2543
      Ig; Immunoglobulin domain

    7. XM_017319943.2 → XP_017175432.1  immunoglobulin-like and fibronectin type III domain-containing protein 1 isoform X2

      Conserved Domains (4) summary
      cd00063
      Location:2144 → 2236
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
      cd00096
      Location:2575 → 2643
      Ig; Immunoglobulin domain
      pfam18362
      Location:127 → 160
      THB; Tri-helix bundle domain
      cl11960
      Location:1 → 80
      Ig; Immunoglobulin domain

    8. XM_006529440.3 → XP_006529503.1  immunoglobulin-like and fibronectin type III domain-containing protein 1 isoform X4

      Conserved Domains (3) summary
      pfam07679
      Location:30 → 121
      I-set; Immunoglobulin I-set domain
      pfam18362
      Location:168 → 201
      THB; Tri-helix bundle domain
      cl11960
      Location:1898 → 1981
      Ig; Immunoglobulin domain

    RNA

    1. XR_001784087.1 RNA Sequence

    2. XR_001784086.1 RNA Sequence

    3. XR_387162.3 RNA Sequence

    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q3KNY0.3 GenPept UniProtKB/Swiss-Prot:Q3KNY0

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