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    Rbm7 RNA binding motif protein 7 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 315634, updated on 27-Dec-2024

    Summary

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    Official Symbol
    Rbm7provided by RGD
    Official Full Name
    RNA binding motif protein 7provided by RGD
    Primary source
    RGD:1308017
    See related
    AllianceGenome:RGD:1308017
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to enable 14-3-3 protein binding activity and RNA binding activity. Predicted to be involved in regulation of alternative mRNA splicing, via spliceosome and snRNA catabolic process. Predicted to be located in nucleoplasm. Predicted to be active in nucleus. Orthologous to human RBM7 (RNA binding motif protein 7). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Spleen (RPKM 250.0), Thymus (RPKM 210.3) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Rbm7 in Genome Data Viewer
    Location:
    8q23
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 8 NC_086026.1 (57728413..57734833, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 8 NC_051343.1 (48831894..48838399, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 8 NC_005107.4 (52823094..52828134, complement)

    Chromosome 8 - NC_086026.1Genomic Context describing neighboring genes Neighboring gene neurexophilin and PC-esterase domain family, member 1 Neighboring gene RNA exonuclease 2 Neighboring gene similar to human chromosome 11 open reading frame 71 Neighboring gene uncharacterized LOC120094143 Neighboring gene nicotinamide N-methyltransferase

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. RBM7 subunit of the NEXT complex binds U-rich sequences and targets 3'-end extended forms of snRNAs. Hrossova D, et al. Nucleic Acids Res, 2015 Apr 30. PMID 25852104, Free PMC Article
    2. p38MAPK/MK2-mediated phosphorylation of RBM7 regulates the human nuclear exosome targeting complex. Tiedje C, et al. RNA, 2015 Feb. PMID 25525152, Free PMC Article
    3. A quantitative 14-3-3 interaction screen connects the nuclear exosome targeting complex to the DNA damage response. Blasius M, et al. Genes Dev, 2014 Sep 15. PMID 25189701, Free PMC Article
    4. The human nuclear exosome targeting complex is loaded onto newly synthesized RNA to direct early ribonucleolysis. Lubas M, et al. Cell Rep, 2015 Jan 13. PMID 25578728
    5. P-TEFb Activation by RBM7 Shapes a Pro-survival Transcriptional Response to Genotoxic Stress. Bugai A, et al. Mol Cell, 2019 Apr 18. PMID 30824372, Free PMC Article

    See all (11) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables 14-3-3 protein binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables RNA binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables pre-mRNA intronic binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables single-stranded RNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables snRNA binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in regulation of alternative mRNA splicing, via spliceosome IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in snRNA catabolic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    NOT located_in nucleolus ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    RNA-binding protein 7

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001108143.2 → NP_001101613.2  RNA-binding protein 7 isoform 2

      See identical proteins and their annotated locations for NP_001101613.2

      Status: PROVISIONAL

      Source sequence(s)
      BC166987
      UniProtKB/TrEMBL
      A6J4A1, B2RZ14, F1M8F0
      Conserved Domains (1) summary
      cl17169
      Location:1 → 17
      RRM_SF; RNA recognition motif (RRM) superfamily

    2. NM_001401005.1 → NP_001387934.1  RNA-binding protein 7 isoform 1

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000008
      UniProtKB/TrEMBL
      A6J4A0

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086026.1 Reference GRCr8

      Range
      57728413..57734833 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039081442.2 → XP_038937370.1  RNA-binding protein 7 isoform X2

      UniProtKB/TrEMBL
      A0A8I5XVE7
      Conserved Domains (1) summary
      cd12592
      Location:9 → 83
      RRM_RBM7; RNA recognition motif (RRM) found in vertebrate RNA-binding protein 7 (RBM7)

    2. XM_063265439.1 → XP_063121509.1  RNA-binding protein 7 isoform X1

    Nucleotide Protein Strain
    Heading Accession and Version

    Gene LinkOut

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    Chemical Information
    Molecular Biology Databases
    Research Materials