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    Hsf3 heat shock transcription factor 3 [ Mus musculus (house mouse) ]

    Gene ID: 245525, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Hsf3provided by MGI
    Official Full Name
    heat shock transcription factor 3provided by MGI
    Primary source
    MGI:MGI:3045337
    See related
    Ensembl:ENSMUSG00000045802 AllianceGenome:MGI:3045337
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    HSF 3; HSTF 3; B230358A15Rik
    Summary
    Enables chromatin DNA binding activity and sequence-specific DNA binding activity. Involved in cellular response to heat and positive regulation of transcription by RNA polymerase II. Located in cytoplasm and nucleus. Is expressed in eye; genital tubercle; genitourinary system; heart; and limb. [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Low expression observed in reference dataset See more
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    Genomic context

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    See Hsf3 in Genome Data Viewer
    Location:
    X C3; X 42.69 cM
    Exon count:
    13
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) X NC_000086.8 (95349781..95499900, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) X NC_000086.7 (96306178..96456294, complement)

    Chromosome X - NC_000086.8Genomic Context describing neighboring genes Neighboring gene Mir223 host gene Neighboring gene microRNA 223 Neighboring gene V-set and immunoglobulin domain containing 4 Neighboring gene predicted gene, 18171 Neighboring gene STARR-seq mESC enhancer starr_47582 Neighboring gene cofilin 1, non-muscle pseudogene Neighboring gene STARR-seq mESC enhancer starr_47583 Neighboring gene hephaestin Neighboring gene ribosomal protein L17, pseudogene 8 Neighboring gene heat shock protein 1 (chaperonin) pseudogene 10

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. A novel mouse HSF3 has the potential to activate nonclassical heat-shock genes during heat shock. Fujimoto M, et al. Mol Biol Cell, 2010 Jan 1. PMID 19864465, Free PMC Article
    2. Atypical heat shock transcription factor HSF5 is critical for male meiotic prophase under non-stress conditions. Yoshimura S, et al. Nat Commun, 2024 Apr 29. PMID 38684656, Free PMC Article
    3. A systems approach reveals that the myogenesis genome network is regulated by the transcriptional repressor RP58. Yokoyama S, et al. Dev Cell, 2009 Dec. PMID 20059953, Free PMC Article
    4. Mouse brain organization revealed through direct genome-scale TF expression analysis. Gray PA, et al. Science, 2004 Dec 24. PMID 15618518
    5. A high-resolution anatomical atlas of the transcriptome in the mouse embryo. Diez-Roux G, et al. PLoS Biol, 2011 Jan 18. PMID 21267068, Free PMC Article

    See all (14) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables DNA-binding transcription factor activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables chromatin DNA binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables sequence-specific DNA binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    acts_upstream_of_or_within cellular response to heat IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in cellular response to heat IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in positive regulation of transcription by RNA polymerase II IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    heat shock factor protein 3

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001310754.2 → NP_001297683.1  heat shock factor protein 3 isoform 1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) encodes the longest isoform (1).
      Source sequence(s)
      AL831708, AL929273
      Consensus CDS
      CCDS81156.1
      UniProtKB/Swiss-Prot
      D0VYS2, D0VYS3
      UniProtKB/TrEMBL
      E9QNK9
      Related
      ENSMUSP00000052508.5, ENSMUST00000059003.5
      Conserved Domains (2) summary
      smart00415
      Location:9 → 112
      HSF; heat shock factor
      pfam03938
      Location:128 → 178
      OmpH; Outer membrane protein (OmpH-like)

    2. NM_001310755.2 → NP_001297684.1  heat shock factor protein 3 isoform 3

      See identical proteins and their annotated locations for NP_001297684.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) has multiple differences, compared to variant 1. These differences result in a distinct 5' UTR and cause translation initiation at an alternate start codon, compared to variant 1. The encoded protein (isoform 3) is shorter than isoform 1.
      Source sequence(s)
      AL732365, AL831708, AL929273
      Consensus CDS
      CCDS85791.1
      UniProtKB/TrEMBL
      A0A0R4J251
      Related
      ENSMUSP00000132248.2, ENSMUST00000164693.8
      Conserved Domains (2) summary
      pfam00447
      Location:23 → 101
      HSF_DNA-bind; HSF-type DNA-binding
      pfam03938
      Location:117 → 167
      OmpH; Outer membrane protein (OmpH-like)

    3. NM_172931.5 → NP_766519.1  heat shock factor protein 3 isoform 2

      See identical proteins and their annotated locations for NP_766519.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) has multiple differences, compared to variant 1. These differences result in a distinct 5' UTR and cause translation initiation at a downstream start codon, compared to variant 1. The encoded protein (isoform 2) is shorter than isoform 1.
      Source sequence(s)
      AL732365, AL831708, AL929273
      Consensus CDS
      CCDS53140.1
      UniProtKB/TrEMBL
      Q8BL67
      Related
      ENSMUSP00000114018.3, ENSMUST00000119035.9
      Conserved Domains (2) summary
      pfam00447
      Location:1 → 44
      HSF_DNA-bind; HSF-type DNA-binding
      pfam03938
      Location:60 → 110
      OmpH; Outer membrane protein (OmpH-like)

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000086.8 Reference GRCm39 C57BL/6J

      Range
      95349781..95499900 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    D0VYS2.1 GenPept UniProtKB/Swiss-Prot:D0VYS2

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